Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Spatiotemporal transcriptomic profiling reveals upregulation of glycolysis pathway genes before overt tauopathy in the PS19 mouse model.

  PMID 41688738 · PMC12992590 · Experimental & molecular medicine · 2026 · 7 claims · 7 setups

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  Pgk1, a glycolytic hub gene, is upregulated in the CA3 hippocampal subregion at 2 months of age, preceding detectable tau tangle pathology, and its expression correlates with tangle severity.

  ps19 spatial immunohistochemistry immunofluorescence

• The complement system contributes to the immunosuppressive microenvironment of uveal melanoma.

  PMID 41803879 · PMC13130498 · Journal of translational medicine · 2026 · 8 claims · 8 setups

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  Primary UM (pUM) preferentially expresses early complement pathway components over terminal membrane attack complex elements, with early factors showing prognostic significance.

  short-term metastatic normal pum bulk label-free single-cell

• Integrated analysis of post-transcriptional regulations reveals insights into acute myeloid leukemia.

  PMID 41407883 · PMC12712020 · Communications biology · 2025 · 8 claims · 6 setups

  Has reproduction · 32

  PTRs computed from integrated transcriptomic/proteomic data of 44 AML samples are highly conserved across AML subtypes and with 29 other human tissues, indicating broadly conserved post-transcriptional mechanisms.

  aml tissues eif4a1 rna-seq cross-tissue fast

• Differential neuronal survival defines a novel axis of sexual dimorphism in the Drosophila brain.

  PMID 41529688 · PMC7618834 · Cell genomics · 2026 · 8 claims · 7 setups

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  Sex differences in the Drosophila central brain do not result from large-scale transcriptional reprogramming, but from selective modifications within shared developmental lineages mediated by dsx and fru.

  drosophila central dsx+ dsx-gal4>mcd8 single-cell differential scenic

• Cytoplasmic LIM domain only 2 enhances tumor endothelial cell migration through integrin β1-mediated focal adhesion signaling.

  PMID 41639897 · PMC12983546 · Acta neuropathologica communications · 2026 · 8 claims · 8 setups

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  LMO2 is highly expressed in tumor-associated vasculature/endothelial cells compared with normal brain vasculature

  glioblastoma orthotopic huvecs huvec-lmo2 single-cell transcriptomic immunofluorescence

• Endothelial PDGF Signaling Dysregulation Impairs Testicular Interstitial Homeostasis in Diabetes.

  PMID 41643060 · PMC13073339 · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026 · 8 claims · 7 setups

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  Testicular endothelial cells (TECs) function as a central signaling hub coordinating intercellular communication within the human testicular interstitium

  testicular testis leydig diabetic single-cell integrative cell-cell

• Single-cell dissection of chronic lung allograft dysfunction reveals convergent and distinct fibrotic mechanisms.

  PMID 41122970 · PMC12581678 · JCI insight · 2025 · 8 claims · 8 setups

  Has reproduction · 75

  CLAD exhibits specific cellular subsets including Fibro.AT2 cells, exhausted CD8+ T cells, and superactivated macrophages

  clad covid-19 million formalin-fixed single-cell single-nucleus integrated

• De novo H3.3K27M-altered diffuse midline glioma in human brainstem organoids to dissect GD2 CAR T cell function.

  PMID 41492091 · PMC12948678 · Nature cancer · 2026 · 8 claims · 8 setups

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  FGF4 supplementation during organoid patterning specifically induces pontine/rostral hindbrain brainstem identity

  hes brainstem day developing bulk immunofluorescence scrna-seq

• The emergence of multiple testicular cell lineages in human stem cell-derived testis-like organoids.

  PMID 41725354 · PMC12989076 · Development (Cambridge, England) · 2026 · 7 claims · 5 setups

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  hiPSC-derived testis-like organoids show significant transcriptional shifts from pluripotency toward gonadal/testicular gene expression compared to undifferentiated stem cells

  hipscs day degs testis-like bulk single-cell term

• Orthogonal cytokine engineering enables novel synthetic effector states escaping canonical exhaustion in tumor-rejecting CD8(+) T cells.

  PMID 37081150 · PMC10154250 · Nature immunology · 2023 · 8 claims · 7 setups

  Has reproduction · 37

  Orthogonal engineering with PD1d/IL-2v/IL-33 reprograms adoptively transferred CD8+ T cells into a novel synthetic effector state (C5/TSE) that deviates from canonical TOX+ exhaustion

  cd8+ b16-ova ot1 mice scrna-seq flow secretion