Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

Publications 1.3k Datasets 392.5k Experiments 9

System / cell line: bone ✕ Assay: transplantation ✕ Clear

Heritable ER stress impairs mitochondrial metabolism and maintenance of hematopoietic stem cells after low-dose irradiation.

PMID 41675062 · PMC12886522 · iScience · 2026 · 8 claims · 8 setups

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Proliferating 20 mGy-irradiated HSC exhibit oxidative stress and altered metabolism with increased mitochondrial ROS and mitochondrial Ca2+ overload compared to non-irradiated HSC

cd45.1 hsc hspc-enriched bone flow carbonylation
Single-cell lineage tracing identifies hemogenic endothelial cells in the adult mouse bone marrow.

PMID 42043300 · PMC13120821 · eLife · 2026 · 8 claims · 8 setups

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Adult bone marrow-resident Cdh5/VE-Cadherin+ endothelial cells produce hematopoietic cell progeny both in vitro and in vivo.

bone lin sorted lethally flow confocal sorted-cell
ChemR23 prevents phenotypic switching of vascular smooth muscle cells into macrophage-like foam cells in atherosclerosis.

PMID 41264461 · PMC13017563 · Cardiovascular research · 2026 · 8 claims · 7 setups

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Non-haematopoietic (vascular) ChemR23 deficiency increases atherosclerotic lesion size and enhances VSMC proliferation and VSMC-derived foam cell formation

apoe adventitia-stripped advanced aortic atherosclerotic bulk single-cell
Adhesion-Related Macrophages Regulate Metabolic Homeostasis Through CAV-1 Dependency.

PMID 41817010 · PMC13159151 · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026 · 8 claims · 8 setups

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Adhesion-related macrophages (ARMs) are a distinct macrophage subpopulation that adheres directly to adipocytes and can be isolated using a novel vortex/bead-based method

ewat facs-sorted arms sort-purified flow bulk atac-seq
A single microRNA miR-195 rescues the arrested B cell development induced by EBF1 deficiency.

PMID 41649478 · PMC12880805 · eLife · 2026 · 8 claims · 8 setups

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Mir195 transduction rescues Ebf1-deficient HPCs, inducing CD19 expression and a B-lineage gene expression program

wild-type ebf1 nog mir195 flow cdna engraftment
Host-derived interleukin-1α drives tumor immunosuppression by reprogramming tumor-associated myeloid cells.

PMID 41547846 · PMC12910057 · NPJ breast cancer · 2026 · 8 claims · 8 setups

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Deletion of host Il1α causes rejection/regression of transplanted breast tumors

h605 pymt tumor-infiltrating two-week orthotopic flow single-cell
Wnt-presenting materials sustain H3K14-acetylation in human skeletal stem cells for tissue engineering and bone repair.

PMID 41844625 · PMC13250124 · NPJ Regenerative medicine · 2026 · 8 claims · 8 setups

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Localized Wnt3a signaling asymmetrically distributes H3K14ac between daughter cells during hSSC asymmetric cell division (ACD), with the Wnt-proximal cell retaining high H3K14ac and higher transcriptional activity (RNApolS2P)

skeletal hssc hsscs wiotm immunofluorescence tunel doxycycline-inducible
Stem cell-associated osteogenic deficiency causes craniofacial deformities with progeroid accumulation of prelamin A.

PMID 41632539 · PMC13041684 · JCI insight · 2026 · 8 claims · 8 setups

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Lmna L648R mutation causes multiple suture craniosynostosis (AF, PF, COR) occurring under low bone density, contrasting with conventional synostosis caused by excessive ossification

skull calvarial suture p7-p10 micro-ct h&e brdu
Epigenetic profiling of hematopoietic stem cells from male mice identifies KDR and PU.1 as regulators of aging transcriptome and caloric restriction response.

PMID 41720793 · PMC13035812 · Nature communications · 2026 · 8 claims · 8 setups

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Lifelong CR reduces white blood cell production and shifts hematopoiesis toward myeloid and thrombo-erythroid lineages while suppressing lymphoid output

peripheral sorted young aged complete flow bulk

Experiments

Heritable ER stress impairs mitochondrial metabolism and maintenance of hematopoietic stem cells after low-dose irradiation.

Single-cell lineage tracing identifies hemogenic endothelial cells in the adult mouse bone marrow.

ChemR23 prevents phenotypic switching of vascular smooth muscle cells into macrophage-like foam cells in atherosclerosis.

Adhesion-Related Macrophages Regulate Metabolic Homeostasis Through CAV-1 Dependency.

A single microRNA miR-195 rescues the arrested B cell development induced by EBF1 deficiency.

Host-derived interleukin-1α drives tumor immunosuppression by reprogramming tumor-associated myeloid cells.

Wnt-presenting materials sustain H3K14-acetylation in human skeletal stem cells for tissue engineering and bone repair.

Stem cell-associated osteogenic deficiency causes craniofacial deformities with progeroid accumulation of prelamin A.

Epigenetic profiling of hematopoietic stem cells from male mice identifies KDR and PU.1 as regulators of aging transcriptome and caloric restriction response.