Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

Publications 1.3k Datasets 392.5k Experiments 22

System / cell line: qpcr ✕ Assay: transwell ✕ Clear

PVT1 lincRNA signals an androgen-dependent transcriptional activation program of oncogenes in prostate cancer cells.

PMID 41792045 · PMC13139993 · International journal of cancer · 2026 · 8 claims · 7 setups

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PVT1 knockdown significantly reduces LNCaP cell proliferation and increases sensitivity to apoptosis

lncap tcga-prad rt-qpcr trypan transwell
Loss of Ezh2 promotes M2-like macrophage polarization in hepatocellular carcinoma.

PMID 41869562 · PMC12999353 · iScience · 2026 · 8 claims · 7 setups

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Hepa1-6 conditioned media (CM) induces M2-like polarization of BMDMs in a dose-dependent manner

bmdms rt-qpcr western flow
Decoding the tumor microenvironment and molecular mechanism: unraveling cervical cancer subpopulations and prognostic signatures through scRNA-Seq and bulk RNA-seq analyses.

PMID 38482016 · PMC10933018 · Frontiers in immunology · 2024 · 8 claims · 8 setups

Has reproduction · 80

C3 PLP2+ Tumor Epithelial Progenitor Cells are a noteworthy subpopulation exerting a pivotal influence on CC differentiation and progression

cervical tcga siha scrna-seq bulk rt-qpcr
Unveiling the immunometabolic landscape of colorectal cancer through PANoptosis-related gene expression.

PMID 41601652 · PMC12832467 · Frontiers in immunology · 2025 · 8 claims · 8 setups

Has reproduction · 41

PANoptosis-related genes show significant expression heterogeneity across CRC samples, with apoptosis-related genes comprising the largest proportion (87.4%)

crc hct116 bulk bulk single-cell rt-qpcr
Identify GDPD3 as a key regulator of epithelial-mesenchymal transition and prostate adenocarcinoma progression via the LPA/LPAR1/AKT axis: transcriptomic and experimental study.

PMID 41562071 · PMC12813044 · Frontiers in immunology · 2025 · 7 claims · 8 setups

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GDPD3 is upregulated in PRAD tumor tissue and its knockdown inhibits tumor cell proliferation, invasion, and migration

prad tcga-prad du145 scrna-seq bulk wgcna
Hypoxia-Induced Osteopontin-Positive Glioma-Associated Macrophages Facilitate Glioma Mesenchymal Transition via NF-κB Pathway Activation.

PMID 41625475 · PMC12857759 · Cancer communications (London, England) · 2026 · 6 claims · 8 setups

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A subset of GAMs with elevated OPN expression accumulates in response to hypoxic stimulation

thp-1 glioma orthotopic gbm bulk single-cell spatial
Histone methyl-transferase G9a inhibition boosts the efficacy of immune checkpoint inhibitors in experimental hepatocellular carcinoma.

PMID 41923620 · PMC13130624 · Cell reports. Medicine · 2026 · 7 claims · 8 setups

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G9a expression inversely correlates with gene signatures predictive of favorable ICI response across multiple HCC patient cohorts

tcga advanced nm53 plc bulk single-cell rt-qpcr
Patient-derived kidney organoids recapitulate ADPKD and facilitate the identification of Rho pathway inhibitors as candidate therapeutics.

PMID 41946363 · PMC13130689 · Cell reports. Medicine · 2026 · 8 claims · 8 setups

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Multi-lineage adult renal organoids (MAROs) can be established directly from adult human kidney tissue and expanded long-term while retaining proximal tubule and collecting duct lineages

maros patient-derived pkd_orgs bulk single-cell immunofluorescence
Epigenome screening highlights that JMJD6 confers an epigenetic vulnerability and mediates sunitinib sensitivity in renal cell carcinoma.

PMID 33634984 · PMC7882098 · Clinical and translational medicine · 2021 · 8 claims · 8 setups

Has reproduction · 85

JMJD6 is identified as a potent epigenetic vulnerability/fitness gene in RCC by integrating GeCK CRISPR screening data with TCGA-KIRC epigenetic regulator survival analysis

pan-cancer tcga-kirc rcc balb crispr rna-seq mtt
Downregulation of Splicing Factor PTBP1 Curtails FBXO5 Expression to Promote Cellular Senescence in Lung Adenocarcinoma.

PMID 39057099 · PMC11276454 · Current issues in molecular biology · 2024 · 8 claims · 8 setups

Has reproduction · 59

PTBP1 is significantly upregulated across multiple cancer types including LUAD, and higher PTBP1 levels are associated with worse LUAD patient survival

cancer luad fibroblast a549 pan-cancer differential replicative
Spatial-reprogramming derived GPNMB(+) macrophages interact with COL6A3(+) fibroblasts to enhance vascular fibrosis in glioblastoma.

PMID 41174767 · PMC12577258 · Genome medicine · 2025 · 8 claims · 8 setups

Has reproduction · 64

COL6A3+ TAFs are a distinct matrix-fibroblast subset significantly enriched in non-responders to neoadjuvant antiangiogenic+ICB combination therapy

gbm ffpe col6a3+ thp-1 scrna-seq spatial multiplex
Loss of mutual protection between human osteoclasts and chondrocytes in damaged joints initiates osteoclast-mediated cartilage degradation by MMPs.

PMID 34811438 · PMC8608887 · Scientific reports · 2021 · 8 claims · 8 setups

Has reproduction · 50

Human osteoclasts differentiate on cartilage, expressing osteoclast markers, and visibly damage the cartilage surface without forming resorption pits or F-actin rings as seen on dentine.

cd14+ osteoclasts conditioned osteoclast gag direct
Exploration of RNA-binding proteins identified RPS27 as a potential regulator associated with Kaposi's sarcoma development.

PMID 40016701 · PMC11866810 · BMC cancer · 2025 · 6 claims · 8 setups

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48 RBP genes are differentially expressed in KS tissue (3 upregulated: PCBP3, L1TD1, PEG10; 45 downregulated, mostly ribosomal protein genes including RPS27)

matched lesion huvecs rna-sequencing rna-seq irip-seq
LIMCH1-enriched extracellular vesicles promote vascular permeability in early-onset preeclampsia.

PMID 41604492 · PMC12851021 · Science advances · 2026 · 8 claims · 8 setups

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LIMCH1 is identified as an Eo-PE-associated EV protein via serum sEV proteomics combined with GEO placental transcriptome datasets

serum placenta jar huvecs lc-ms exoview nanoflow
KRT15 identified by scRNA-Seq and machine learning as stemness regulator and prognostic biomarker in ESCC.

PMID 41907411 · PMC13018899 · iScience · 2026 · 8 claims · 8 setups

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A malignant epithelial subpopulation (Cluster 0) with the highest CytoTRACE stemness potential and highest EMT activity exists in ESCC scRNA-seq data

escc degs eca109 kyse180 scrna-seq machine immunohistochemistry
Multi-Omics reveals SPP1 + malignant and CXCR4(+) TAM crosstalk predicts immunotherapy response in lung adenocarcinoma.

PMID 42045760 · PMC13187092 · Discover oncology · 2026 · 8 claims · 8 setups

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SPP1+ malignant and CXCR4+ TAM crosstalk drives CD8 T cell exhaustion and induces poor immunotherapy response

luad tcga-luad epithelial a549 single-cell spatial bulk
Comprehensive analysis of transcriptomics and radiomics revealed the potential of TEDC2 as a diagnostic marker for lung adenocarcinoma.

PMID 39553728 · PMC11569783 · PeerJ · 2024 · 8 claims · 8 setups

Has reproduction · 80

WGCNA identified 214 key genes in the blue module most correlated with LUAD

tcga-luad merged tedc2-associated a549 wgcna differential machine
Leveraging the germ layer development patterns to predict prognosis and identify MEST as a novel therapeutic target in glioma.

PMID 41501725 · PMC12870398 · Cancer cell international · 2026 · 7 claims · 8 setups

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MEST is a key oncogenic GLD-related gene and a novel therapeutic target in glioma, identified via a machine learning feature selection framework

bulk single-cell tcga glioma gsva aucell machine
A P4HA2 hypoxia signature derived from single cell atlas stratifies conserved subtypes with prognostic significance in cervical squamous cell carcinoma.

PMID 41559646 · PMC12910786 · BMC cancer · 2026 · 6 claims · 8 setups

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A tumor cell metaprogram (MP7) identified from scRNA-seq of CSCC shows elevated hypoxia, invasion, metastasis, proliferation, and angiogenesis scores compared to other metaprograms.

cscc tcga-cscc mp7 siha single-cell bulk gene
Increased IL4I1 expression predicts poor survival and modulates the immune microenvironment in acute myeloid leukemia.

PMID 41680858 · PMC12910993 · Journal of translational medicine · 2026 · 8 claims · 8 setups

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IL4I1 mRNA expression is significantly elevated in AML compared to normal controls

tcga-laml bone thp-1-derived thp-1 bulk kaplan-meier deg

Experiments

PVT1 lincRNA signals an androgen-dependent transcriptional activation program of oncogenes in prostate cancer cells.

Loss of Ezh2 promotes M2-like macrophage polarization in hepatocellular carcinoma.

Decoding the tumor microenvironment and molecular mechanism: unraveling cervical cancer subpopulations and prognostic signatures through scRNA-Seq and bulk RNA-seq analyses.

Unveiling the immunometabolic landscape of colorectal cancer through PANoptosis-related gene expression.

Identify GDPD3 as a key regulator of epithelial-mesenchymal transition and prostate adenocarcinoma progression via the LPA/LPAR1/AKT axis: transcriptomic and experimental study.

Hypoxia-Induced Osteopontin-Positive Glioma-Associated Macrophages Facilitate Glioma Mesenchymal Transition via NF-κB Pathway Activation.

Histone methyl-transferase G9a inhibition boosts the efficacy of immune checkpoint inhibitors in experimental hepatocellular carcinoma.

Patient-derived kidney organoids recapitulate ADPKD and facilitate the identification of Rho pathway inhibitors as candidate therapeutics.

Epigenome screening highlights that JMJD6 confers an epigenetic vulnerability and mediates sunitinib sensitivity in renal cell carcinoma.

Downregulation of Splicing Factor PTBP1 Curtails FBXO5 Expression to Promote Cellular Senescence in Lung Adenocarcinoma.

Spatial-reprogramming derived GPNMB(+) macrophages interact with COL6A3(+) fibroblasts to enhance vascular fibrosis in glioblastoma.

Loss of mutual protection between human osteoclasts and chondrocytes in damaged joints initiates osteoclast-mediated cartilage degradation by MMPs.

Exploration of RNA-binding proteins identified RPS27 as a potential regulator associated with Kaposi's sarcoma development.

LIMCH1-enriched extracellular vesicles promote vascular permeability in early-onset preeclampsia.

KRT15 identified by scRNA-Seq and machine learning as stemness regulator and prognostic biomarker in ESCC.

Multi-Omics reveals SPP1 + malignant and CXCR4(+) TAM crosstalk predicts immunotherapy response in lung adenocarcinoma.

Comprehensive analysis of transcriptomics and radiomics revealed the potential of TEDC2 as a diagnostic marker for lung adenocarcinoma.

Leveraging the germ layer development patterns to predict prognosis and identify MEST as a novel therapeutic target in glioma.

A P4HA2 hypoxia signature derived from single cell atlas stratifies conserved subtypes with prognostic significance in cervical squamous cell carcinoma.

Increased IL4I1 expression predicts poor survival and modulates the immune microenvironment in acute myeloid leukemia.