Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Lymphodepleting preconditioning impairs host antitumor immunity induced by adoptive T cell therapy in mouse models.

  PMID 41912536 · PMC13172322 · Nature communications · 2026 · 8 claims · 8 setups

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  ACT with TCR-transgenic (OTI) CD8+ T cells eradicates established B16F10-OTI tumors and expands host CD8+ T cells with tumor-reactive (PD-1+GzmB-/PD-1+GzmB+, Tpex/Tex) and tissue-resident phenotypes

  b16f10-oti draining ragko c57bl flow tumor antibody

• Deubiquitination enzyme USP35 negatively regulates MAVS signaling to inhibit anti-tumor immunity.

  PMID 40016186 · PMC11868397 · Cell death & disease · 2025 · 8 claims · 8 setups

  Has reproduction · 81

  USP35 interacts with MAVS and removes its K63-linked polyubiquitin chains, inhibiting viral-induced MAVS-TBK1-IRF3 activation and downstream inflammatory gene expression

  tumor melanoma tcga-skcm hek293t bioinformatics geo kaplan-meier

• SPP1(+) macrophage-driven interactions shape the tumor microenvironment in lymph node metastatic acral melanoma.

  PMID 42020397 · PMC13230793 · Cell death & disease · 2026 · 8 claims · 8 setups

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  LN+ acral melanoma shows preferential SPP1+ signaling, including autocrine amplification within SPP1+ macrophages and paracrine interaction with S100A8+ melanoma cells via the SPP1-CD44 axis

  tumor microarray thp-1 a375 scrna-seq immunofluorescence western