Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

Publications 1.3k Datasets 392.5k Experiments 20

System / cell line: resistance ✕ Assay: tumor ✕ Clear

Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain.

PMID 15737014 · PMC549606 · PLoS medicine · 2005 · 7 claims · 6 setups

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A secondary EGFR exon 20 mutation (T790M) is found in tumors from patients with acquired resistance to gefitinib or erlotinib

tumor 293t nsclc direct fluorescent rt-pcr
Molecular Biomarker of Drug Resistance Developed From Patient-Derived Organoids Predicts Survival of Colorectal Cancer Patients.

PMID 35425715 · PMC9004628 · Frontiers in oncology · 2022 · 8 claims · 7 setups

Has reproduction · 53

Patient-derived colorectal cancer organoids (CRCOs) can be established from surgical CRC tissue with an 82% success rate (41/50)

crc colorectal crcos crco organoid drug bulk
Therapeutic synergies that overcome carboplatin resistance in triple-negative breast cancer.

PMID 41630032 · PMC13037280 · Journal of experimental & clinical cancer research : CR · 2026 · 8 claims · 8 setups

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Four isogenic carboplatin-resistant (CR) PDX pairs (WHIM30, BCM-2147, BCM-3887, BCM-7482) were generated via serial in vivo carboplatin exposure to model acquired resistance in TNBC

isogenic pdx ffpe carboplatin-resistant bulk single-cell nuclear
Developmental reprogramming underlies chemotherapy resistance in favorable-histology Wilms tumor.

PMID 41850280 · PMC13103949 · Cell reports · 2026 · 8 claims · 8 setups

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Chemotherapy-resistant KT-47R tumors show blastemal predominance and reduced stromal content compared to pre-treatment KT-47PT

kt-47 kt-47pt histology whole-exome cut&tag
The Molecular and Functional Landscape of Resistance to FOLFIRI Chemotherapy in Metastatic Colorectal Cancer.

PMID 40981426 · PMC12877753 · Cancer discovery · 2026 · 8 claims · 7 setups

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FOLFIRI-resistant PDX tumors show transcriptional upregulation of innate immunity and mitochondrial metabolism genes and reduced expression of DNA polymerase POLD1

mcrc pdx patients patient-derived drug whole-exome bulk
Detection of mutations in EGFR in circulating lung-cancer cells.

PMID 18596266 · PMC3551471 · The New England journal of medicine · 2008 · 8 claims · 7 setups

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The CTC-chip microfluidic device isolates CTCs from NSCLC patients in sufficient quantity and purity to permit EGFR mutational analysis

blood archived nsclc plasma microfluidic allele-specific standard
Multimodal-based analysis of single-cell ATAC-seq data enables highly accurate delineation of clinically relevant tumor cell subpopulations.

PMID 41530870 · PMC12888741 · Genome medicine · 2026 · 8 claims · 8 setups

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MAAS integrates chromatin accessibility, CNVs, and SNVs from scATAC-seq data to identify functional tumor cell subpopulations

tumor pediatric b-cell glioblastoma scatac-seq bulk gene
Targeting Wnt/β-catenin and circadian regulator restores PRC2/EZH2-controlled chromatin bivalency and suppresses cell state diversity.

PMID 41842971 · PMC13132380 · The Journal of clinical investigation · 2026 · 8 claims · 8 setups

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PRC2i/EZH2i alone or combined with AR inhibitors induce diverse cell state programs (CSPs) that increase tumor cell invasion, metastasis, and drug resistance despite only modest suppression of tumor growth.

lncap pca pdx clinical viability tumor ic50
Single-cell transcriptomic analysis reveals intra-tumoral heterogeneity and immunotherapy strategies in high-grade serous ovarian cancer.

PMID 41907410 · PMC13018870 · iScience · 2026 · 8 claims · 8 setups

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scRNA-seq of 17 HGSOC tissue samples reveals seven major cell types and extensive intra-tumoral heterogeneity

hgsoc epithelial tcga gse165897 single-cell copy kegg
Extensive androgen receptor enhancer heterogeneity in primary prostate cancers underlies transcriptional diversity and metastatic potential.

PMID 36450752 · PMC9712620 · Nature communications · 2022 · 8 claims · 8 setups

Has reproduction · 70

AR chromatin binding is highly heterogeneous between primary prostate tumors, with <5% of all AR binding sites (ARBS) shared by half of the 88 tumors analyzed

prostate normal pca lncap chip-seq starr-seq luciferase
Merger of ayurveda and tissue culture-based functional genomics: inspirations from systems biology.

PMID 18348714 · PMC2311278 · Journal of translational medicine · 2008 · 8 claims · 8 setups

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Crude LASH extract and its purified components (withanone, withaferin A) act through distinct but partially overlapping molecular gene-regulatory networks

tumor-derived tumor lash gene cytotoxicity sirna ribozyme
Ex Vivo Immuno-Oncology Platform Reveals Spatial T-cell Infiltration Patterns Linked to ATR Inhibition Responses in High-Grade Serous Ovarian Cancer.

PMID 41563843 · PMC7618831 · Cancer immunology research · 2026 · 8 claims · 8 setups

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iPDCs cultured on human omentum gel (OmGel) recapitulate tumor genomic and histologic characteristics while retaining intratumoral immune cells

formalin-fixed blood dissociated ipdcs histopathology whole-exome flow
Stemming cancer: functional genomics of cancer stem cells in solid tumors.

PMID 18561035 · PMC2758383 · Stem cell reviews · 2008 · 8 claims · 8 setups

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Cancer stem cells are a minority tumor subpopulation that alone can maintain indefinite tumor growth, as shown by serial transplantation experiments

solid fetal cd133+ breast facs neurosphere genome-wide
Distinct molecular and tumor microenvironment characteristics of mucinous adenocarcinoma in colorectal cancer.

PMID 42100746 · PMC13145884 · iScience · 2026 · 8 claims · 8 setups

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MAC is associated with significantly worse overall survival than CAC, but only within the MSS subtype

tcga-crc surgically crc epithelial whole-exome copy consensus
Single-Cell Lineage Tracing Uncovers Resistance Signatures and Sensitizing Strategies to FLT3 Inhibitors in Acute Myeloid Leukemia.

PMID 41270153 · PMC7618455 · Cancer research · 2026 · 8 claims · 8 setups

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ReSisTrace single-cell lineage tracing identifies pre-resistant and pre-sensitive cell states to FLT3 inhibitors midostaurin and quizartinib in FLT3-ITD-positive MOLM-13 AML cells before treatment

molm-13 aml-pdx1 single-cell lineage gene
Increased cyclin D1 expression can mediate BRAF inhibitor resistance in BRAF V600E-mutated melanomas.

PMID 18790768 · PMC2651569 · Molecular cancer therapeutics · 2008 · 8 claims · 6 setups

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CDK4 mutations (K22Q, R24C, R24L) alone do not confer resistance to the BRAF inhibitor SB590885

melanoma metastatic wm39 451lu mtt pcr array
scATD: a high-throughput and interpretable framework for single-cell cancer drug resistance prediction and biomarker identification.

PMID 40501071 · PMC12159290 · Briefings in bioinformatics · 2025 · 8 claims · 6 setups

Has reproduction · 62

scATD enables high-throughput single-cell drug sensitivity prediction for new patients without model parameter retraining via bidirectional Bi-AdaIN style transfer

panglaodb cancer geo gse137829 single-cell bulk
5-HT reuptake blockade induces pyroptosis in BRAF(V600E)-mutated melanomas via remodeling histone serotonylation.

PMID 41494533 · PMC12866116 · Cell reports. Medicine · 2026 · 8 claims · 8 setups

Has reproduction · 40

High-throughput screening of 90 FDA-approved antidepressants identifies PH as an alternative therapeutic for BRAF V600E-mutated melanoma

braf a375 gfp-tph1-overexpressing yumm1.7 high-throughput ic50 xenograft
Genomics: applications in mechanism elucidation.

PMID 19166886 · PMC2698023 · Advanced drug delivery reviews · 2009 · 8 claims · 8 setups

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Genomic tools require no a priori knowledge of a compound's mode of action and can reveal biological pathways (metabolism, distribution, off-target effects) in addition to the precise mechanism of action.

extract panel saccharomyces inbred affinity cytotoxicity genome-wide
MetaScreener: a robust dual-mode framework for directional prioritization of actionable signatures through multi-dataset and multi-approach integration.

PMID 41845481 · PMC13107662 · Journal of translational medicine · 2026 · 8 claims · 7 setups

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MetaScreener is a dual-mode framework (DiffMetaScreener for discrete labels, CorMetaScreener for continuous variables) integrating over 4,000 analysis pipelines to compute activation/inhibition directionality indices (ADI/IDI/DI) for gene signatures

crc independent ctrp rko differential robustness single-cell

Experiments

Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain.

Molecular Biomarker of Drug Resistance Developed From Patient-Derived Organoids Predicts Survival of Colorectal Cancer Patients.

Therapeutic synergies that overcome carboplatin resistance in triple-negative breast cancer.

Developmental reprogramming underlies chemotherapy resistance in favorable-histology Wilms tumor.

The Molecular and Functional Landscape of Resistance to FOLFIRI Chemotherapy in Metastatic Colorectal Cancer.

Detection of mutations in EGFR in circulating lung-cancer cells.

Multimodal-based analysis of single-cell ATAC-seq data enables highly accurate delineation of clinically relevant tumor cell subpopulations.

Targeting Wnt/β-catenin and circadian regulator restores PRC2/EZH2-controlled chromatin bivalency and suppresses cell state diversity.

Single-cell transcriptomic analysis reveals intra-tumoral heterogeneity and immunotherapy strategies in high-grade serous ovarian cancer.

Extensive androgen receptor enhancer heterogeneity in primary prostate cancers underlies transcriptional diversity and metastatic potential.

Merger of ayurveda and tissue culture-based functional genomics: inspirations from systems biology.

Ex Vivo Immuno-Oncology Platform Reveals Spatial T-cell Infiltration Patterns Linked to ATR Inhibition Responses in High-Grade Serous Ovarian Cancer.

Stemming cancer: functional genomics of cancer stem cells in solid tumors.

Distinct molecular and tumor microenvironment characteristics of mucinous adenocarcinoma in colorectal cancer.

Single-Cell Lineage Tracing Uncovers Resistance Signatures and Sensitizing Strategies to FLT3 Inhibitors in Acute Myeloid Leukemia.

Increased cyclin D1 expression can mediate BRAF inhibitor resistance in BRAF V600E-mutated melanomas.

scATD: a high-throughput and interpretable framework for single-cell cancer drug resistance prediction and biomarker identification.

5-HT reuptake blockade induces pyroptosis in BRAF(V600E)-mutated melanomas via remodeling histone serotonylation.

Genomics: applications in mechanism elucidation.

MetaScreener: a robust dual-mode framework for directional prioritization of actionable signatures through multi-dataset and multi-approach integration.