Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• CX-5461 and doxorubicin activate a shared DNA damage-associated transcriptional response in human cardiomyocytes.

  PMID 41543508 · PMC12958809 · G3 (Bethesda, Md.) · 2026 · 6 claims · 7 setups

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  CX induces cell death in iPSC-derived cardiomyocytes at micromolar concentrations

  ipsc-derived undifferentiated colorectal viability γ-h2ax bulk

• The N-terminus and alpha-5, alpha-6 helices of the pro-apoptotic protein Bax, modulate functional interactions with the anti-apoptotic protein Bcl-xL.

  PMID 17519046 · PMC1890283 · BMC cell biology · 2007 · 8 claims · 8 setups

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  Deletion of the first 29 N-terminal amino acids (Bax 30-192) causes constitutive mitochondrial accumulation and high cytotoxicity that is poorly inhibited by Bcl-xL or Bcl-2.

  jurkat drosophila hek apoptotic uas-gal4 western

• Single-Cell Lineage Tracing Uncovers Resistance Signatures and Sensitizing Strategies to FLT3 Inhibitors in Acute Myeloid Leukemia.

  PMID 41270153 · PMC7618455 · Cancer research · 2026 · 8 claims · 8 setups

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  ReSisTrace single-cell lineage tracing identifies pre-resistant and pre-sensitive cell states to FLT3 inhibitors midostaurin and quizartinib in FLT3-ITD-positive MOLM-13 AML cells before treatment

  molm-13 aml-pdx1 single-cell lineage gene

• Experimental identification and in silico prediction of bacterivory in green algae.

  PMID 33649548 · PMC8245530 · The ISME journal · 2021 · 7 claims · 6 setups

  Has reproduction · 93

  Five prasinophyte strains (Pterosperma cristatum NIES626, Pyramimonas parkeae CCMP726, Pyramimonas parkeae NIES254, Nephroselmis pyriformis RCC618, Dolichomastix tenuilepis CCMP3274) ingest live fluorescently labeled bacteria, detected by microscopy and/or flow cytometry

  prasinophyte same green pelagibaca flow epifluorescence gene-based

• Establishment and characterisation of six human biliary tract cancer cell lines.

  PMID 12107841 · PMC2376107 · British journal of cancer · 2002 · 8 claims · 8 setups

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  Six new human biliary tract cancer cell lines (SNU-245, SNU-308, SNU-478, SNU-869, SNU-1079, SNU-1196) were established and characterised from Korean patients

  biliary snu lines microdissected culture fingerprinting pcr-sscp

• Genomics and proteomics of immune modulatory effects of a butanol fraction of echinacea purpurea in human dendritic cells.

  PMID 18847511 · PMC2571112 · BMC genomics · 2008 · 8 claims · 8 setups

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  [BF/S+L/Ep] butanol fraction from E. purpurea enhances maturation of human immature dendritic cells (increased CD83 expression)

  immature idcs [bf phytocompounds flow mtt lal

• Out-of-frame CBX3::ALK fusion drives ALK activation and therapy response.

  PMID 41887222 · PMC13130619 · Cell reports. Medicine · 2026 · 8 claims · 8 setups

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  A CBX3::ALK out-of-frame fusion was identified in a patient with metastatic melanoma

  metastatic cutaneous tumor hek293t targeted immunohistochemistry fluorescence

• Small molecule splicing modulators that disrupt O-GlcNAc homeostasis.

  PMID 41526361 · PMC12894984 · Nature communications · 2026 · 8 claims · 7 setups

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  Kinase inhibitors GSK690693 and Y-33075 act as splicing modulators that disrupt O-GlcNAc homeostasis by simultaneously downregulating both OGT and OGA

  hct116 recombinant hek293t high-content western udp-glo

• Ex Vivo Immuno-Oncology Platform Reveals Spatial T-cell Infiltration Patterns Linked to ATR Inhibition Responses in High-Grade Serous Ovarian Cancer.

  PMID 41563843 · PMC7618831 · Cancer immunology research · 2026 · 8 claims · 8 setups

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  iPDCs cultured on human omentum gel (OmGel) recapitulate tumor genomic and histologic characteristics while retaining intratumoral immune cells

  formalin-fixed blood dissociated ipdcs histopathology whole-exome flow

• miR-4478 Accelerates Nucleus Pulposus Cells Apoptosis Induced by Oxidative Stress by Targeting MTH1.

  PMID 36130054 · PMC9897280 · Spine · 2023 · 7 claims · 8 setups

  Has reproduction · 100

  miR-4478 is upregulated in NP tissues from IVDD patients compared to controls

  annulus npcs mirna quantitative fluorescence

• Broad network-based predictability of Saccharomyces cerevisiae gene loss-of-function phenotypes.

  PMID 18053250 · PMC2246260 · Genome biology · 2007 · 8 claims · 4 setups

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  Loss-of-function phenotypes in yeast are predictable from a gene's connections in a functional gene network via guilt-by-association.

  saccharomyces guilt-by-association comparison network-guided

• Next-generation sequencing.

  PMID 20030863 · PMC2797692 · Breast cancer research : BCR · 2009 · 8 claims · 7 setups

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  Massively parallel sequencing can simultaneously capture base-pair mutations, copy number aberrations and somatic rearrangements of a cancer genome in a single experiment

  individuals metastatic acute oestrogen whole-exome whole-genome large-scale

• YAP1 Dysfunction Promotes Molecular Properties Linked to Breast Cancer Susceptibility.

  PMID 41431390 · PMC13040214 · Cancer prevention research (Philadelphia, Pa.) · 2026 · 7 claims · 8 setups

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  YAP1 nuclear localization and mRNA expression significantly increase in luminal epithelial cells (LEp) with increased age and with genetic risk for breast cancer (e.g., BRCA1/2 mutation carriers)

  breast hmec post-stasis 184d-p16sh ihc bulk odds

• Bacterial reporter-paired scRNA sequencing reveals cross talk between zinc starvation and zinc toxicity in macrophage antibacterial defense.

  PMID 41802048 · PMC12993976 · Proceedings of the National Academy of Sciences of the United States of America · 2026 · 8 claims · 8 setups

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  Macrophages starve intracellular E. coli of zinc to sensitize them to subsequent zinc toxicity, coupling zinc starvation and zinc toxicity in a single antimicrobial response

  monocyte-derived hmdm zntr-dual macrophages confocal high-throughput flow

• Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2-EZH2-Mediated Microtubule Destabilization.

  PMID 41782374 · PMC13159132 · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026 · 8 claims · 8 setups

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  Chronic hypoxia disrupts spermatogenesis by blocking the round-to-elongated spermatid transition, governed by the ASXL2–EZH2 axis

  testes seminiferous sperm including single-cell western transmission

• Ectopic CD11c Drives SMAD3-Mediated Aberrant Antigen Presentation and Epithelial-Mesenchymal Transition in Esophageal Squamous Cell Carcinoma.

  PMID 41799568 · PMC12963642 · Cancer communications (London, England) · 2026 · 8 claims · 13 setups

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  An ESCC epithelial cell subcluster with ectopic CD11c (ITGAX) expression, found in both mice and humans, exhibits concurrent impaired antigen presentation and EMT phenotypes

  4-nqo-induced escc esophageal lung multiplex flow whole-genome

• Stemming cancer: functional genomics of cancer stem cells in solid tumors.

  PMID 18561035 · PMC2758383 · Stem cell reviews · 2008 · 8 claims · 8 setups

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  Cancer stem cells are a minority tumor subpopulation that alone can maintain indefinite tumor growth, as shown by serial transplantation experiments

  solid fetal cd133+ breast facs neurosphere genome-wide