Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2-EZH2-Mediated Microtubule Destabilization.

  PMID 41782374 · PMC13159132 · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026 · 8 claims · 8 setups

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  Chronic hypoxia disrupts spermatogenesis by blocking the round-to-elongated spermatid transition, governed by the ASXL2–EZH2 axis

  testes seminiferous sperm including single-cell western transmission

• Alginate oligosaccharides improve germ cell development and testicular microenvironment to rescue busulfan disrupted spermatogenesis.

  PMID 32194870 · PMC7053202 · Theranostics · 2020 · 8 claims · 8 setups

  Has reproduction · 79

  AOS rescues busulfan-disrupted spermatogenesis in vivo by increasing the proportion of germ cells (spermatocytes and spermatids)

  icr spermatozoa testis plasma single-cell computer-assisted immunofluorescence

• Stage-specific epigenetic priming amplifies gene activation during lineage commitment.

  PMID 41894493 · PMC13025117 · Science advances · 2026 · 8 claims · 8 setups

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  Full-body Msl1 knockout causes embryonic lethality by E10.5, with morphological/developmental delay detectable already at E8.5

  embryos e9.5 mesc-derived bright-field western 10x

• STAG2 loss amplifies EWS-FLI1-driven microsatellite enhancer activity promoting Ewing sarcoma aggressiveness.

  PMID 41950086 · PMC13079922 · Proceedings of the National Academy of Sciences of the United States of America · 2026 · 8 claims · 8 setups

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  STAG2 loss does not globally attenuate EWS-FLI1 activity but reprograms its chromatin binding, redirecting it from short (1-4x) GGAA-repeat sites toward long/multimeric (≥5x) GGAA-repeat microsatellite enhancers

  a673 tc-71 chip-seq immunoblot atac-seq

• Unbalanced chromatin binding of Polycomb complexes drives neurodevelopmental disorders.

  PMID 41653922 · PMC13034722 · Molecular cell · 2026 · 8 claims · 8 setups

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  Heterozygous de novo missense mutations in RING1 and RNF2 are found in individuals with neurodevelopmental/intellectual disability phenotypes

  cohorts prc1 ring1a elegans variant structural western