Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

Publications 1.3k Datasets 392.5k Experiments 17

System / cell line: developmental ✕ Assay: western ✕ Clear

Developmental stage dominates cell-type identity and reveals a chromatin regulatory function for Rad50 in Drosophila.

PMID 41978263 · PMC13076223 · Nucleic acids research · 2026 · 8 claims · 8 setups

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Developmental stage is a stronger determinant of transcriptional identity than cell type across Drosophila neurons, glia, and hemocytes

neurons cns e16 salivary bulk atac-seq western
Developmental dynamics of catshark cranial neural crest cells provide insights into gnathostome facial evolution.

PMID 41987760 · PMC13200729 · Development (Cambridge, England) · 2026 · 8 claims · 8 setups

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The molecular toolkit of CNCCs is largely conserved across jawed vertebrates (gnathostomes)

scyliorhinus catshark chicken immunofluorescence single-cell umap
The effect of diet on the human gut microbiome: a metagenomic analysis in humanized gnotobiotic mice.

PMID 20368178 · PMC2894525 · Science translational medicine · 2009 · 7 claims · 6 setups

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Germ-free C57BL/6J mice can be stably and heritably colonized with a human fecal microbiota, reproducing much of the donor's bacterial diversity.

fecal postnatal luminal pooled 16s shotgun body
Cycloheximide-resistant ribosomes reveal adaptive translation dynamics in C. elegans.

PMID 40929375 · PMC12477835 · Genetics · 2026 · 8 claims · 8 setups

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A P55Q substitution in ribosomal protein RPL-36A confers strong resistance to cycloheximide in C. elegans

elegans crispr-cas9 larval rna-seq
CITED2 is a druggable epigenetic switch coupling neuronal maturation to regenerative decline.

PMID 41731079 · PMC13083982 · EMBO molecular medicine · 2026 · 8 claims · 8 setups

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The transition from immature non-polarized to mature polarized DRG neurons (E12.5-E17.5) is associated with loss of gene expression signatures needed for regenerative growth competence.

drg sciatic rna-seq integrated immunofluorescence
A new family of giardial cysteine-rich non-VSP protein genes and a novel cyst protein.

PMID 17183673 · PMC1762436 · PloS one · 2006 · 8 claims · 7 setups

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HCNCp is a novel invariant (non-variant) cyst protein belonging to a new family of high-cysteine membrane proteins (HCMp) abundant in the Giardia genome

giardia serial northern western
Prediction of Alzheimer's disease-specific phospholipase c gamma-1 SNV by deep learning-based approach for high-throughput screening.

PMID 33397809 · PMC7826347 · Proceedings of the National Academy of Sciences of the United States of America · 2021 · 7 claims · 7 setups

Has reproduction · 48

An AD-specific frameshift insertion SNV in exon 27 of mouse PLCγ1 causes abnormal exon skipping (exons 26-30) during mRNA maturation in 5xFAD cortex

cortex forebrain plcγ1 bulk rna-seq-based western
Integrative Multiomic Classification Reveals Distinct Origins and Evolutionary Trajectories of Thymic Epithelial Tumors.

PMID 41671387 · PMC13012242 · Cancer research · 2026 · 8 claims · 8 setups

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TETs stratify into three molecular subgroups with distinct origins: GTF2I-type thymomas, CN-type thymomas, and thymic carcinomas

tet thymic hek293t whole-exome whole-genome bulk
Polycomb repressive-deubiquitinase complex safeguards oocyte epigenome and female fertility by restraining Polycomb activity.

PMID 41851118 · PMC13153255 · Nature communications · 2026 · 8 claims · 7 setups

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BAP1 (PR-DUB catalytic subunit) restricts pervasive, genome-wide H2AK119ub1 accumulation in mouse oocytes

zygotes oocytes fgo fgos microinjection bulk western
Lactate and histone H3K18 lactylation are associated with metabolic control of gene expression in the retina.

PMID 41950290 · PMC13095125 · PLoS genetics · 2026 · 8 claims · 8 setups

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Enhanced ATP production during mouse retinal development is achieved primarily through an increase in glycolysis rather than mitochondrial respiration.

retina histones histone retinal seahorse lactate-glo ldh
Mutations in UPF3B, a member of the nonsense-mediated mRNA decay complex, cause syndromic and nonsyndromic mental retardation.

PMID 17704778 · PMC2872770 · Nature genetics · 2007 · 8 claims · 6 setups

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Mutations in UPF3B cause syndromic (Lujan-Fryns syndrome, FG syndrome) and nonsyndromic X-linked mental retardation

probands lymphoblastoid lcls tissues gene quantitative cycloheximide
Aurkb deficiency disrupts microglial development, homeostasis and hinders remyelination following cuprizone-induced demyelination.

PMID 41704758 · PMC12907124 · iScience · 2026 · 8 claims · 8 setups

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Aurkb is upregulated in a subset of fetal/neonatal microglia and in microglia following CPZ-induced demyelination and in MS patient microglia

microglia brain neonatal corpus scrna-seq western immunofluorescence
Sphingosine-1-Phosphate-derived 2-Hexadecenal is a central mediator of ocular neovascularization by inhibiting Sphingosine-1-Phosphate receptor 5.

PMID 41980976 · PMC13079744 · Nature communications · 2026 · 8 claims · 8 setups

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Loss of ALDH3B1 impairs 2-HD detoxification and causes retinal vascular abnormalities in zebrafish without affecting trunk vasculature

zebrafish crispr quantitative immunoblot
Targeted and personalized immunotherapy in lung adenocarcinoma: single-cell RNA sequencing of MAFF+ tumor cells and the therapeutic potential of FOS.

PMID 40936936 · PMC12420628 · Frontiers in immunology · 2025 · 7 claims · 8 setups

Has reproduction · 71

A highly stem-like C0 MAFF+ tumor cell subtype dominates invasive LUAD, producing chemokines and activating lipid metabolism

luad tumor a549 single-cell infercnv pseudotime
Oxidative stress and GPX2 control pancreatic vs. non-pancreatic cell fate in human endoderm.

PMID 41484137 · PMC12881361 · Nature communications · 2026 · 8 claims · 8 setups

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GPX2 is a critical regulator of human posterior foregut differentiation, with oxidative stress acting as a key determinant of pancreatic vs. non-pancreatic cell fate

hpsc-derived hpsc fetal bulk immunofluorescence flow
Dissecting tumor heterogeneity in colorectal cancer: uncovering the role of BCL2L1(+) cells through single-cell analysis.

PMID 41958675 · PMC13056825 · Frontiers in immunology · 2026 · 8 claims · 8 setups

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scRNA-seq identifies five CRC tumor cell subtypes, with the C4 BCL2L1+ subtype predominantly enriched in liver metastases and showing enhanced proliferation, metabolic reprogramming, and anti-apoptotic activity

crc epcs malignant tcga scrna-seq infercnv cytotrace
SLC25A37 as a novel therapeutic target for benign prostatic hyperplasia: integrative analyses of single-cell RNA sequencing and genome-wide association studies.

PMID 41726128 · PMC12917586 · Open medicine (Warsaw, Poland) · 2026 · 8 claims · 8 setups

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SLC25A37 is causally associated with increased BPH risk, supported by MR, Bayesian colocalization, and reverse MR analyses

prostate gwas eqtl bph single-cell mendelian bayesian

Experiments

Developmental stage dominates cell-type identity and reveals a chromatin regulatory function for Rad50 in Drosophila.

Developmental dynamics of catshark cranial neural crest cells provide insights into gnathostome facial evolution.

The effect of diet on the human gut microbiome: a metagenomic analysis in humanized gnotobiotic mice.

Cycloheximide-resistant ribosomes reveal adaptive translation dynamics in C. elegans.

CITED2 is a druggable epigenetic switch coupling neuronal maturation to regenerative decline.

A new family of giardial cysteine-rich non-VSP protein genes and a novel cyst protein.

Prediction of Alzheimer's disease-specific phospholipase c gamma-1 SNV by deep learning-based approach for high-throughput screening.

Integrative Multiomic Classification Reveals Distinct Origins and Evolutionary Trajectories of Thymic Epithelial Tumors.

Polycomb repressive-deubiquitinase complex safeguards oocyte epigenome and female fertility by restraining Polycomb activity.

Lactate and histone H3K18 lactylation are associated with metabolic control of gene expression in the retina.

Mutations in UPF3B, a member of the nonsense-mediated mRNA decay complex, cause syndromic and nonsyndromic mental retardation.

Aurkb deficiency disrupts microglial development, homeostasis and hinders remyelination following cuprizone-induced demyelination.

Sphingosine-1-Phosphate-derived 2-Hexadecenal is a central mediator of ocular neovascularization by inhibiting Sphingosine-1-Phosphate receptor 5.

Targeted and personalized immunotherapy in lung adenocarcinoma: single-cell RNA sequencing of MAFF+ tumor cells and the therapeutic potential of FOS.

Oxidative stress and GPX2 control pancreatic vs. non-pancreatic cell fate in human endoderm.

Dissecting tumor heterogeneity in colorectal cancer: uncovering the role of BCL2L1(+) cells through single-cell analysis.

SLC25A37 as a novel therapeutic target for benign prostatic hyperplasia: integrative analyses of single-cell RNA sequencing and genome-wide association studies.