Experiments
Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).
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CTCF/cohesin-binding sites are susceptible to replication-associated DNA damage and genomic instability in cancer cells.
PMID 41630911 · PMC12860730 · iScience · 2026 · 8 claims · 8 setups
CTCF and cohesin (RAD21) remain co-bound to DNA throughout interphase, including during the S (replication) phase, in HeLa cells
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OCT4 enhances the firing efficiency of late DNA replication origins in mouse embryonic stem cells.
PMID 41540072 · PMC12910074 · Nature communications · 2026 · 8 claims · 8 setups
In mESCs, a subset of initiation zones (IZs) mapping to mid or late replication-timing (RT) domains fire within 1-2 hours of S-phase entry, much earlier than expected for their RT classification.
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Has reproduction · 90
Evolutionary repair: Changes in multiple functional modules allow meiotic cohesin to support mitosis.
PMID 32155147 · PMC7138332 · PLoS biology · 2020 · 8 claims · 7 setups
Replacing Scc1 with Rec8 in mitosis impairs sister chromosome cohesion, advances the timing of genome replication, and reduces reproductive fitness by 45%
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Cycloheximide-resistant ribosomes reveal adaptive translation dynamics in C. elegans.
PMID 40929375 · PMC12477835 · Genetics · 2026 · 8 claims · 8 setups
A P55Q substitution in ribosomal protein RPL-36A confers strong resistance to cycloheximide in C. elegans
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SOX2 phosphorylation during mitosis limits genomic damage.
PMID 41213799 · PMC12863253 · Genes & development · 2026 · 8 claims · 8 setups
SOX2 (but not SOX9) remains dynamically bound to mitotic chromatin throughout all mitotic stages in neural stem cells