Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

Publications 1.3k Datasets 392.5k Experiments 216

System / cell line: lung ✕ Clear

Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth.

PMID 19920251 · PMC2812789 · Science signaling · 2009 · 7 claims · 8 setups

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Oncogenic FGFR1 directly phosphorylates PKM2 at tyrosine 105 (Y105), inhibiting its enzymatic activity

293t kg-1a recombinant h1299 ms-based co-transfection enzymatic
DBTSS provides a tissue specific dynamic view of Transcription Start Sites.

PMID 19910371 · PMC2808897 · Nucleic acids research · 2010 · 8 claims · 8 setups

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DBTSS update adds ~330 million new TSS Seq tags from 31 different human/mouse cell types or culture conditions.

normal dld1 beas2b ramos tss comparative
Comprehensive genomic analysis reveals clinically relevant molecular distinctions between thymic carcinomas and thymomas.

PMID 19861435 · PMC2783876 · Clinical cancer research : an official journal of the American Association for Cancer Research · 2009 · 7 claims · 7 setups

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Comprehensive genomic analysis shows thymic carcinomas are molecularly distinct from thymomas

resected thymic previously mass dideoxynucleotide array
Malaria severity and human nitric oxide synthase type 2 (NOS2) promoter haplotypes.

PMID 19859740 · PMC2939908 · Human genetics · 2010 · 7 claims · 7 setups

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NOS2 promoter haplotypes are not consistently associated with malaria severity or malarial anemia across three independent Tanzanian study populations

tanzanian a549 muheza-tanga sscp pcr restriction
The application of genomics to emerging zoonotic viral diseases.

PMID 19855817 · PMC2734983 · PLoS pathogens · 2009 · 8 claims · 8 setups

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High-throughput sequencing, mRNA expression profiling, and SNP microarray analysis enable rapid identification and genomic characterization of emerging zoonotic pathogens and host responses to them.

siv-infected plasmacytoid migratory influenza transcriptional tlr fecal
Loss of heterozygosity at 2q37 in sporadic Wilms' tumor: putative role for miR-562.

PMID 19789318 · PMC2756455 · Clinical cancer research : an official journal of the American Association for Cancer Research · 2009 · 8 claims · 8 setups

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2q37 harbors a tumor suppressor gene important in Wilms tumor pathogenesis

sporadic wilms fetal 293t loh multiplex genome-wide
mtDNA G10398A variant in African-American women with breast cancer provides resistance to apoptosis and promotes metastasis in mice.

PMID 19763141 · PMC2909846 · Journal of human genetics · 2009 · 8 claims · 8 setups

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The G10398A cybrid shows slower proliferation and delayed cell cycle progression (G1 accumulation, decreased G2/M) compared to wild-type G10398 cybrid

blood mitochondria g10398a cybrid pcr cybrid spectrophotometric
Introduction: the challenge of incidental findings.

PMID 18547190 · PMC2587006 · The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics · 2008 · 8 claims · 5 setups

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No consensus exists on how to handle incidental findings in human subjects research

publicly healthy asymptomatic families empirical functional colonography
Putting science over supposition in the arena of personalized genomics.

PMID 18665132 · PMC2531214 · Nature genetics · 2008 · 6 claims · 3 setups

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There is a rapidly widening gap between gene-disease association discovery and research into the public health/clinical utility of that information.

adults same tested baseline multiplex telephone-based
spliceJAC: transition genes and state-specific gene regulation from single-cell transcriptome data.

PMID 36321549 · PMC9627675 · Molecular systems biology · 2022 · 8 claims · 6 setups

Has reproduction · 53

spliceJAC quantifies multivariate mRNA splicing from unspliced/spliced count matrices to construct cell state-specific gene-gene (Jacobian) interaction matrices.

two-gene three-gene emt circuit simulation grn scrna-seq
Crunching the bio-numbers.

PMID 14664241 · PMC1316909 · Environmental health perspectives · 2003 · 8 claims · 6 setups

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The eTag Assay System rapidly identifies genes and related proteins without complex sample preparation or follow-up bioinformatics, unlike microarrays

blood model brain lung etag sirna addl
A new era for proteomics research?

PMID 19014405 · PMC2614486 · Genome biology · 2008 · 8 claims · 8 setups

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Refined mass spectrometry instrumentation and software now make whole-proteome coverage of model organisms in a single experiment conceivable

proteins lines kinases breast mass silac kinase-specific
From the gamma-glutamyl cycle to the glycan cycle: a road with many turns and pleasant surprises.

PMID 19840938 · PMC2787308 · The Journal of biological chemistry · 2009 · 8 claims · 8 setups

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γ-Glutamyl transpeptidase (GGT) activity in rat liver shows biphasic changes during azo dye-induced hepatocarcinogenesis, mirroring the oncofetal expression pattern of α-fetoprotein

liver tissues ascites hepatoma spectrophotometric enzyme glycan
RNA interference in functional genomics and medicine.

PMID 12808314 · PMC3055057 · Journal of Korean medical science · 2003 · 8 claims · 7 setups

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RNAi is sequence-specific gene silencing induced by double-stranded RNA and is mediated by ~22-nt siRNAs generated from long dsRNA by the RNase III enzyme Dicer.

caenorhabditis drosophila mammalian postnatal dsrna biochemical synthetic
Severe combined immunodeficiency (SCID) and attention deficit hyperactivity disorder (ADHD) associated with a Coronin-1A mutation and a chromosome 16p11.2 deletion.

PMID 19097825 · PMC2692687 · Clinical immunology (Orlando, Fla.) · 2009 · 8 claims · 7 setups

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CORO1A deficiency, caused by a paternal 2bp frameshift mutation combined with a maternal de novo 600kb deletion at chromosome 16p11.2, is the molecular cause of this patient's T-B+NK+ SCID

ebv-transformed genomic father peripheral intracellular snp sequencing
Localization studies of rare missense mutations in cystic fibrosis transmembrane conductance regulator (CFTR) facilitate interpretation of genotype-phenotype relationships.

PMID 18951463 · PMC2785447 · Human mutation · 2008 · 5 claims · 5 setups

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R1070P and R1070W CFTR mutants show apical membrane localization/insertion defects consistent with their associated disease severity

polarized mdck mdck-cftr patients confocal surface western

Experiments

Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth.

DBTSS provides a tissue specific dynamic view of Transcription Start Sites.

Comprehensive genomic analysis reveals clinically relevant molecular distinctions between thymic carcinomas and thymomas.

Malaria severity and human nitric oxide synthase type 2 (NOS2) promoter haplotypes.

The application of genomics to emerging zoonotic viral diseases.

Loss of heterozygosity at 2q37 in sporadic Wilms' tumor: putative role for miR-562.

mtDNA G10398A variant in African-American women with breast cancer provides resistance to apoptosis and promotes metastasis in mice.

Introduction: the challenge of incidental findings.

Putting science over supposition in the arena of personalized genomics.

spliceJAC: transition genes and state-specific gene regulation from single-cell transcriptome data.

Crunching the bio-numbers.

A new era for proteomics research?

From the gamma-glutamyl cycle to the glycan cycle: a road with many turns and pleasant surprises.

RNA interference in functional genomics and medicine.

Severe combined immunodeficiency (SCID) and attention deficit hyperactivity disorder (ADHD) associated with a Coronin-1A mutation and a chromosome 16p11.2 deletion.

Localization studies of rare missense mutations in cystic fibrosis transmembrane conductance regulator (CFTR) facilitate interpretation of genotype-phenotype relationships.