Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

Publications 1.3k Datasets 392.5k Experiments 301

System / cell line: in-vitro ✕ Clear

Structural insights into the inhibited states of the Mer receptor tyrosine kinase.

PMID 19028587 · PMC2686088 · Journal of structural biology · 2009 · 8 claims · 8 setups

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Nucleotide-bound (ADP and ANP/AMP-PNP) Mer kinase domain adopts an autoinhibited DFG-Asp-in/αC-Glu-out conformation with an activation-loop residue inserted into the active site

recombinant phosphorylated mer x-ray positional differential
Genomics and proteomics of immune modulatory effects of a butanol fraction of echinacea purpurea in human dendritic cells.

PMID 18847511 · PMC2571112 · BMC genomics · 2008 · 8 claims · 8 setups

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[BF/S+L/Ep] butanol fraction from E. purpurea enhances maturation of human immature dendritic cells (increased CD83 expression)

immature idcs [bf phytocompounds flow mtt lal
The impact of microRNAs on protein output.

PMID 18668037 · PMC2745094 · Nature · 2008 · 8 claims · 8 setups

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MicroRNA targeting for protein repression occurs primarily through seed-matched sites (6mer, 7mer-A1, 7mer-m8, 8mer) located in favourable predicted contexts within 3′ UTRs

hela neutrophils bone mir-223 quantitative blot microarray
A modular analysis framework for blood genomics studies: application to systemic lupus erythematosus.

PMID 18631455 · PMC2727981 · Immunity · 2008 · 7 claims · 8 setups

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Transcriptional modules constructed from coordinately expressed genes across 8 diseases form stable, biologically coherent functional units

pbmc genes monocytes original microarray literature stimulation
A novel splice-site mutation of TULP1 underlies severe early-onset retinitis pigmentosa in a consanguineous Israeli Muslim Arab family.

PMID 18432314 · PMC2329669 · Molecular vision · 2008 · 6 claims · 5 setups

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A novel homozygous splice-site mutation, c.1495+2_1495+3insT, in the donor splice-site of TULP1 intron 14 underlies autosomal recessive early-onset RP in family TB13.

genomic tulp1 y79 haplotype direct mismatch-primer
Genetic and functional association of FAM5C with myocardial infarction.

PMID 18430236 · PMC2383879 · BMC medical genetics · 2008 · 8 claims · 5 setups

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SNPs within FAM5C show genetic linkage to and association with myocardial infarction in the GENECARD family-based sample

genecard cathgen donor aortic genome-wide case-control expression
Functional characterisation of the TSC1-TSC2 complex to assess multiple TSC2 variants identified in single families affected by tuberous sclerosis complex.

PMID 18302728 · PMC2291454 · BMC medical genetics · 2008 · 8 claims · 8 setups

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Functional assays of TSC1–TSC2 complex activity can distinguish pathogenic TSC2 mutations from rare polymorphisms when multiple variants segregate in one family

hek immunoprecipitated tsc2 peripheral coimmunoprecipitation rheb s6k-t389
Modified H5 promoter improves stability of insert genes while maintaining immunogenicity during extended passage of genetically engineered MVA vaccines.

PMID 19969118 · PMC2821965 · Vaccine · 2010 · 7 claims · 8 setups

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rMVA expressing multiple antigens under the mH5 promoter exhibit remarkable genetic stability and maintain potent immunogenicity after serial passage

rmva-infected individually bhk-21 pbmc qpcr western southern
The oxazolidinone derivative locostatin induces cytokine appeasement.

PMID 19917702 · PMC2799496 · Journal of immunology (Baltimore, Md. : 1950) · 2009 · 7 claims · 7 setups

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RKIP is differentially localized (not differentially expressed) on the proteomic map after in vivo T cell recall compared to resting state

ot-i splenocytes fractions serum intracellular proteomics sds-page
NeMeSys: a biological resource for narrowing the gap between sequence and function in the human pathogen Neisseria meningitidis.

PMID 19818133 · PMC2784325 · Genome biology · 2009 · 8 claims · 5 setups

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Determined and manually annotated the complete genome sequence of N. meningitidis clinical isolate strain 8013

meningitidis archived strain neisseria whole-genome transposon targeted
Genetics and irritable bowel syndrome: from genomics to intermediate phenotype and pharmacogenetics.

PMID 19655247 · PMC2903621 · Digestive diseases and sciences · 2009 · 8 claims · 8 setups

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Candidate gene association studies with IBS symptom phenotype (e.g., SLC6A4, GNB3, IL-10) have generally produced inconsistent, unreplicated results.

ibs ibs-d ibs-c subjects candidate genotyping mutational
Expansion of the geranylgeranyl pyrophosphate synthase gene family underlies the evolution of terpenoid biosynthesis in termites.

PMID 42044146 · PMC13143122 · PLoS biology · 2026 · 8 claims · 8 setups

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A gene family arose through a series of duplications of geranylgeranyl pyrophosphate synthase (GGPPS) in the common ancestor of Neoisoptera, the terpene-producing termite lineage.

body diterpenoids neotenicus fpps gc-ms nmr genome
Vitamin C Conditioning Generates Tumor-Targeting CAR T Cells with Superior Cytotoxicity and Fitness in a Posttransplant Lymphoproliferative Disorder Tumor Model.

PMID 41416402 · PMC13136873 · Molecular cancer therapeutics · 2026 · 8 claims · 8 setups

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VitC conditioning enhances transduction efficiency and proliferative capacity, yielding a higher yield of CD4+ and CD8+ CAR19-Ts

cd3+ je6-1 car19-ts coculture flow nf-κb cytotoxicity
The ubiquitin ligase KLHL6 drives resistance to CD8(+) T cell dysfunction.

PMID 41535474 · PMC12979199 · Nature · 2026 · 8 claims · 8 setups

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KLHL6 is a dual-negative regulator of both T cell exhaustion and mitochondrial dysfunction

cd8+ cas9+ sgklhl6-transduced klhl6 bulk pooled flow
Integrating complex genomic datasets and tumour cell sensitivity profiles to address a 'simple' question: which patients should get this drug?

PMID 20003409 · PMC2799438 · BMC medicine · 2009 · 8 claims · 5 setups

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A panel of 48 genomically characterized breast cancer cell lines can model patient tumour heterogeneity to identify biomarkers predicting response to PG-11047

panel breast 250-gene candidate genome growth pathway
Protein microarray technology.

PMID 17126887 · PMC1828913 · Mechanisms of ageing and development · 2007 · 8 claims · 8 setups

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Protein microarrays enable high-throughput characterization of protein biochemical activities across an entire proteome in a single experiment

yeast sh2 protein-protein protein-dna chromatin
Manually curated transcriptomics data collection for toxicogenomic assessment of engineered nanomaterials.

PMID 33558569 · PMC7870661 · Scientific data · 2021 · 8 claims · 6 setups

Has reproduction · 94

A unified, easily accessible, reusable collection of ENM transcriptomics data was lacking prior to this work despite large amounts of existing data

enms gene rna-sequencing dynamic
Genetically engineered stem cell-derived retinal grafts for improved retinal reconstruction after transplantation.

PMID 34409267 · PMC8361135 · iScience · 2021 · 8 claims · 6 setups

Has reproduction · 84

Bhlhb4−/− and Islet1−/− pluripotent cell lines differentiate into retinal organoids with similar timing, morphology, and gene expression to wt lines up to around DD15

bhlhb4− nrl-gfp rd1 fluorescence rt-pcr microarray
52-kD SS-A/Ro: genomic structure and identification of an alternatively spliced transcript encoding a novel leucine zipper-minus autoantigen expressed in fetal and adult heart.

PMID 7561701 · PMC2192297 · The Journal of experimental medicine · 1995 · 7 claims · 7 setups

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The 52-kD SS-A/Ro gene spans 10 kb of DNA and is composed of seven exons, with the translation initiation codon in exon 2 and the leucine zipper encoded by exon 4.

molt-4 placental placenta fetal cdna genomic race
p53 as a potential predictive factor of response to chemotherapy: feasibility of p53 assessment using a functional test in yeast from trucut biopsies in breast cancer patients.

PMID 11875738 · PMC2375302 · British journal of cancer · 2002 · 8 claims · 6 setups

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p53 status can be reliably determined by yeast functional assay from single frozen sections of trucut biopsies

frozen plasmids single extracted p53 sanger laser

Experiments

Structural insights into the inhibited states of the Mer receptor tyrosine kinase.

Genomics and proteomics of immune modulatory effects of a butanol fraction of echinacea purpurea in human dendritic cells.

The impact of microRNAs on protein output.

A modular analysis framework for blood genomics studies: application to systemic lupus erythematosus.

A novel splice-site mutation of TULP1 underlies severe early-onset retinitis pigmentosa in a consanguineous Israeli Muslim Arab family.

Genetic and functional association of FAM5C with myocardial infarction.

Functional characterisation of the TSC1-TSC2 complex to assess multiple TSC2 variants identified in single families affected by tuberous sclerosis complex.

Modified H5 promoter improves stability of insert genes while maintaining immunogenicity during extended passage of genetically engineered MVA vaccines.

The oxazolidinone derivative locostatin induces cytokine appeasement.

NeMeSys: a biological resource for narrowing the gap between sequence and function in the human pathogen Neisseria meningitidis.

Genetics and irritable bowel syndrome: from genomics to intermediate phenotype and pharmacogenetics.

Expansion of the geranylgeranyl pyrophosphate synthase gene family underlies the evolution of terpenoid biosynthesis in termites.

Vitamin C Conditioning Generates Tumor-Targeting CAR T Cells with Superior Cytotoxicity and Fitness in a Posttransplant Lymphoproliferative Disorder Tumor Model.

The ubiquitin ligase KLHL6 drives resistance to CD8(+) T cell dysfunction.

Integrating complex genomic datasets and tumour cell sensitivity profiles to address a 'simple' question: which patients should get this drug?

Protein microarray technology.

Manually curated transcriptomics data collection for toxicogenomic assessment of engineered nanomaterials.

Genetically engineered stem cell-derived retinal grafts for improved retinal reconstruction after transplantation.

52-kD SS-A/Ro: genomic structure and identification of an alternatively spliced transcript encoding a novel leucine zipper-minus autoantigen expressed in fetal and adult heart.

p53 as a potential predictive factor of response to chemotherapy: feasibility of p53 assessment using a functional test in yeast from trucut biopsies in breast cancer patients.