Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Single cell multiomics revealed fibrotic trajectories of endometrial cells and interaction with the pro-fibrotic macrophages in intrauterine adhesion.

  PMID 41947225 · PMC13188631 · Genome medicine · 2026 · 8 claims · 8 setups

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  Human IUA endometrium contains a novel ACTA2+KRT8+ myofibrotic-epithelial subpopulation and an ACTA2+CD31+ myofibrotic-endothelial subpopulation, in addition to myofibroblasts

  endometrial iua scrna-seq snatac-seq spatial

• Glioblastoma invasion into different organoid hosts reveals cell-intrinsic and proliferative migratory programs.

  PMID 41959666 · PMC13059114 · iScience · 2026 · 8 claims · 8 setups

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  GB cells invade both neural and endodermal organoid hosts (lineage-independent), whereas non-malignant neural progenitor cells show markedly reduced infiltration

  gbm1 gfp-gbm1 facs-sorted post-invasion image-based immunofluorescence single-cell

• Developmental stage dominates cell-type identity and reveals a chromatin regulatory function for Rad50 in Drosophila.

  PMID 41978263 · PMC13076223 · Nucleic acids research · 2026 · 8 claims · 8 setups

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  Developmental stage is a stronger determinant of transcriptional identity than cell type across Drosophila neurons, glia, and hemocytes

  neurons cns e16 salivary bulk atac-seq western

• Ex vivo modeling of lung tissue resident antimicrobial responses.

  PMID 41989160 · PMC13170359 · mBio · 2026 · 8 claims · 8 setups

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  Murine PCLS (mPCLS) reproduce core antiviral transcriptional responses seen in vivo after IAV infection but lack a type II interferon response, likely due to absence of infiltrating immune cells.

  pcls lung mpcls iav-primed bulk flow rnascope

• Interferon-γ selectively promotes survival of alveolar progenitor cells in a human lung organoid model.

  PMID 41992061 · PMC13187038 · The EMBO journal · 2026 · 8 claims · 7 setups

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  A new human ALVO model supports long-term expansion of alveolar progenitor cells and defined serum-free differentiation into AT1-like cells, improving on prior HTII-280-selection/serum-based protocols

  alvos organoid-derived sorted viability scrna-seq immunofluorescence

• XAP5 CIRCADIAN TIMEKEEPER coordinates circadian rhythms and anthocyanin biosynthesis independently of splicing.

  PMID 42014049 · PMC13227948 · Plant physiology · 2026 · 8 claims · 5 setups

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  XCT and PRP19 antagonistically regulate circadian period length through splicing-independent mechanisms

  arabidopsis computational luciferase rna-seq gene

• A conserved hormonal signalling-H2A.Z axis rapidly reorganizes 3D chromatin interactions in adipocyte thermogenesis.

  PMID 42014869 · PMC13218939 · Nature metabolism · 2026 · 8 claims · 8 setups

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  β3-AR signalling rapidly reorganizes chromatin loops within 4 hours of stimulation

  brown rna-seq micro-c pro-seq

• PW1(+) cells give rise to cardiac adipocytes during development and myofibroblasts following injury.

  PMID 42035143 · PMC13255232 · Stem cell research & therapy · 2026 · 8 claims · 8 setups

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  PW1+ cardiac mesenchymal cells serve as a progenitor population that gives rise to cardiac adipocytes during postnatal heart development

  heart pw1 sorted non-cardiomyocyte quantitative genetic adipogenesis

• Multi-Omics reveals SPP1 + malignant and CXCR4(+) TAM crosstalk predicts immunotherapy response in lung adenocarcinoma.

  PMID 42045760 · PMC13187092 · Discover oncology · 2026 · 8 claims · 8 setups

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  SPP1+ malignant and CXCR4+ TAM crosstalk drives CD8 T cell exhaustion and induces poor immunotherapy response

  luad tcga-luad epithelial a549 single-cell spatial bulk

• BCAT1-dependent HIF-1α stabilization is a targetable metabolic vulnerability in hepatocellular carcinoma.

  PMID 42061407 · PMC13198305 · Cell reports. Medicine · 2026 · 7 claims · 8 setups

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  BCAT1 depletes α-KG to inhibit PHD and stabilize HIF-1α under hypoxic conditions in HCC

  mhcc97l capillary western bulk

• ERG is a regulator of dynamic and reversible endothelial plasticity.

  PMID 42067854 · PMC13135260 · Genome medicine · 2026 · 7 claims · 8 setups

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  Loss of ERG initiates a progressive EndMT program in which endothelial identity is lost rapidly (by 24 h) before mesenchymal identity, barrier dysfunction, and enhanced migration emerge later (by 72 h)

  telohaec huvec atac-seq rna-seq western

• Characteristics of Burkholderia pyrrocinia and the biocontrol mechanism by which it affects lily bulb rot caused by F. oxysporum.

  PMID 42112433 · PMC13149453 · Frontiers in microbiology · 2026 · 7 claims · 8 setups

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  Strain YFLYS026 was isolated from lily rhizosphere soil and identified as Burkholderia pyrrocinia via 16S rDNA/gyrB sequencing and phylogenetics

  phytopathogenic oxysporum tissue-cultured lily plate double-plate pot

• A step forward for Shiga toxin-producing Escherichia coli identification and characterization in raw milk using long-read metagenomics.

  PMID 36748417 · PMC9836091 · Microbial genomics · 2022 · 8 claims · 6 setups

  Has reproduction · 75

  Long-read metagenomics enables isolation-independent identification and characterization of eae-positive STEC directly from raw milk.

  pure enriched stec-negative extracted ont real-time artificial

• Single-cell ATAC-seq analysis of human embryoid bodies reveals crucial transcription factor networks involved in early germ layer specification.

  PMID 41906160 · PMC13154528 · Cell & bioscience · 2026 · 7 claims · 7 setups

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  scATAC-seq of human EBs can classify cells into the three germ layers and, via pseudotime analysis, identify 'early committed cells' at the onset of each germ layer.

  embryoid embryonic hescs single-cell mesendoderm neural

• Gene expression study on peripheral blood identifies progranulin mutations.

  PMID 18551524 · PMC2773201 · Annals of neurology · 2008 · 7 claims · 3 setups

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  PGRN is highly expressed in peripheral blood (97th percentile of all array genes)

  peripheral blood-derived microarray direct real-time

• Endogenous Fatty Acid Synthesis Drives Brown Adipose Tissue Involution.

  PMID 33440156 · PMC8240962 · Cell reports · 2021 · 8 claims · 8 setups

  Has reproduction

  Endogenous fatty acid synthesis (DNL), regulated by ChREBP, is the central driver of BAT whitening/involution at thermoneutrality.

  bat fatty lipidomics qpcr

• Endogenous retroviral elements LTR8B and MER65 rewire PSG9 regulation to control trophoblast syncytialization and pre-eclampsia risk.

  PMID 41796334 · PMC12969887 · Genome biology · 2026 · 8 claims · 8 setups

  Has reproduction · 68

  LTR8B is a placentally-relevant cis-regulatory element (CRE), notably within the PSG array

  sghpl-4 bewo recombinant serum chip-exonuclease transient quantitative

• Protocol for total RNA sequencing analysis of extracellular RNA from biofluids.

  PMID 42149717 · PMC13213309 · STAR protocols · 2026 · 8 claims · 6 setups

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  This protocol enables total RNA sequencing library preparation of extracellular RNA (exRNA) from blood plasma using SMART (Switching Mechanism At 5' end of RNA Template) cDNA synthesis technology, from plasma preparation through sequencing data analysis.

  blood urine seminal conditioned sequencing qpcr-based

• A cross-species approach to identify transcriptional regulators exemplified for Dnajc22 and Hnf4a.

  PMID 28642491 · PMC5481429 · Scientific reports · 2017 · 8 claims · 8 setups

  Has reproduction · 76

  Hnf4a is a major transcriptional regulator of Dnajc22

  atlas roadmap liver-specific kidney co-expression transcription reanalysis

• The exonuclease Xrn1 activates transcription and translation of mRNAs encoding membrane proteins.

  PMID 30899024 · PMC6428865 · Nature communications · 2019 · 8 claims · 8 setups

  Has reproduction · 85

  Xrn1 promotes translation of a specific group of transcripts encoding membrane proteins

  cerevisiae western renilla polysome