Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

Publications 1.3k Datasets 392.5k Experiments 924

System / cell line: blood ✕ Clear

The functional landscape of alternative splicing in hematopoietic lineage commitment.

PMID 41593078 · PMC12946277 · Nature communications · 2026 · 7 claims · 8 setups

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FAScore, a Random Forest model integrating 19 dynamic, structural, and conservation features, predicts functional exon-skipping AS events with high accuracy in a species- and lineage-specific manner.

umbilical bone fetal zebrafish bulk machine exon
Tumour-intrinsic features shape T cell differentiation through precursor to symptomatic multiple myeloma.

PMID 41644568 · PMC12982522 · Nature communications · 2026 · 8 claims · 6 setups

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MM is not characterized by T cell exhaustion but by antigen-driven terminal memory differentiation, unlike solid cancers

bone cd69+ cd8+ smm single-cell cite-seq gene
Antigen specificity of clonally enriched CD8(+) T cells in multiple sclerosis.

PMID 41644766 · PMC12956596 · Nature immunology · 2026 · 8 claims · 7 setups

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A subset of 23 highly expanded, CSF-enriched CD8+ T cell clonotypes exists predominantly in the CSF of the MS/CIS cohort.

paired cd8+ cd4+ csf single-cell differential pseudotime
Multiomics combined drugs to explore the potential mechanism and treatment of ankylosing spondylitis.

PMID 41673882 · PMC13047816 · Journal of orthopaedic surgery and research · 2026 · 8 claims · 8 setups

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Effector CD8+ memory T (Tem) cells are significantly elevated in AS patients compared to healthy controls

bone peripheral effector interspinous single-cell cibersortx cell-cell
Innate antiviral and immune functions associated with the HIV reservoir decay after anti-PD-1 therapy.

PMID 41680482 · PMC12920136 · Nature medicine · 2026 · 7 claims · 7 setups

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Anti-PD-1 therapy triggers a rapid (within 24 hours) systemic cascade of increased IFN/antiviral, monocyte, and CD8+ T cell effector transcriptomic modules alongside decreased plasma TGFβ.

pbmcs plasma pbmc publicly bulk plasma integrated
α4 Integrin blockade impairs CD8+ T cell neuroimmune surveillance following SIV infection.

PMID 41734020 · PMC13078879 · The Journal of clinical investigation · 2026 · 8 claims · 8 setups

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α4 blockade preserves CD4+ Th1 cell access to brain parenchyma but impairs CD8 effector recruitment, disrupting antiviral control

siv-infected live macaque cd4-δitga4 flow antibody single-cell
Metabolic quiescence of naive-like memory T cells precedes and maintains antigen-specific T cell memory.

PMID 41735532 · PMC12956582 · Nature immunology · 2026 · 8 claims · 8 setups

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CD8+ T cells upregulate glycolysis to fuel anabolic needs for proliferation but predominantly use oxidative phosphorylation (OXPHOS) for energy production during the acute phase (days 7-28) after YFV vaccination

peripheral cd8+ ns4b+ antigen-specific flow scrna-seq cite-seq
A new chromosome-level genome assembly for western painted turtle Chrysemys picta bellii, a model for extreme physiological adaptations.

PMID 41792601 · PMC13077969 · BMC genomics · 2026 · 6 claims · 8 setups

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A new haplotype-resolved, chromosome-level reference genome assembly (SLU_Cpb5.0) was generated for C. picta bellii using combined PacBio HiFi, 10x Genomics Chromium, Hi-C, and Bionano optical mapping data from a single individual.

genomic ultra-high tissues heart 10x pacbio hi-c
Metabolic Adaptation of CD8⁺ T Cells Limits the Efficacy of Fatty Acid Oxidation Inhibition in Type 1 Diabetes.

PMID 41800251 · PMC12965062 · International journal of biological sciences · 2026 · 8 claims · 8 setups

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TMZ enhances mitochondrial membrane potential and suppresses fatty acid oxidation (FAO) in human T cells

peripheral endoc-βh5 nod pancreatic mitochondrial extracellular glucose-stimulated
Comprehensive cellular analysis with single-nucleus RNA-seq of archived PAXgene whole blood samples.

PMID 41844163 · PMC13030975 · Cell reports methods · 2026 · 8 claims · 7 setups

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Cell lysis (CL) nuclei isolation yields substantially more nuclei and less biased immune cell proportions than mechanical separation (MS)

frozen paxgene cl-derived thawed single-nucleus confocal brightfield
Single-Cell Multi-Tissue T Cell Clonal Dynamics Reveal Distinct Immune Coercion Landscapes in MSI and MSS Colorectal Cancer.

PMID 41898550 · PMC13027115 · International journal of molecular sciences · 2026 · 8 claims · 5 setups

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Immunotherapy response in CRC is better explained by TCR clonal dynamics (expansion, migration, functional transitions) than by MSI status alone

crc single high-quality cd4+ scrna-seq tcr pseudotime
Integrated transcriptome and single-cell sequencing analysis identify blood-pancreas shared lncRNA biomarkers in new-onset T2DM.

PMID 41915667 · PMC13037964 · PloS one · 2026 · 8 claims · 6 setups

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1,709 lncRNAs are differentially expressed in peripheral blood of new-onset T2DM patients vs controls

peripheral pancreatic predicted bulk weighted single-cell
Single-cell and spatial profiling of peripheral blood and synovium unveils pro-arthritis CNBP(+) myeloid cells.

PMID 41928282 · PMC13169754 · Journal of translational medicine · 2026 · 8 claims · 8 setups

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Peripheral CNBP+ monocytes are expanded and show elevated 'inflammatory response' pathway scores in arthritis patients

peripheral blood synovial arthritis single-cell bulk immunofluorescence
Single-cell epigenetic and transcriptomic states across the continuum of monoclonal B cell lymphocytosis to chronic lymphocytic leukemia.

PMID 41987205 · PMC13192028 · Genome biology · 2026 · 8 claims · 6 setups

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The HC-MBL to CLL transition shows subclonal, epigenetic and transcriptomic stability, consistent with a continuous disease spectrum rather than distinct evolutionary phases.

cd19+ lc-mbl single scrna-seq mtscatac-seq asap-seq
TBL1X/TBL1XR1 govern β-cell identity through a PAX6-containing gene regulatory network.

PMID 42020373 · PMC13102947 · Nature communications · 2026 · 8 claims · 8 setups

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TBL/R1 are crucial regulators of β-cell identity and determinants of diabetes development and progression

pancreatic fed paraffin-embedded pancreas qpcr blood oral
pmid-42030936

PMID 42030936 · PMC13198318 · 8 claims · 6 setups

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LLIs exhibit a transcriptional age younger than expected for their chronological age, as measured by clocks trained on younger controls (YCs).

peripheral european same age-related bulk gene machine
Enforced MYC expression directs a distinct transcriptional state during plasma cell differentiation.

PMID 40721291 · PMC12305944 · Life science alliance · 2025 · 8 claims · 7 setups

Has reproduction · 74

Acute MYC (T58I) and BCL2 overexpression drives an aberrant B-cell differentiation phenotype with altered surface marker expression while functional antibody secretion is retained

peripheral rna-seq flow edu antibody
Early days: genomics and human responses to infection.

PMID 16679048 · PMC7108404 · Current opinion in microbiology · 2006 · 8 claims · 8 setups

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DNA microarray-based transcript profiling of primate/human responses to infection has begun to yield new insights into host-pathogen interactions but is limited by unresolved methodological challenges.

peripheral liver gastric brain microarray
Polymorphic repeat in AIB1 does not alter breast cancer risk.

PMID 11056690 · PMC13920 · Breast cancer research : BCR · 2000 · 7 claims · 3 setups

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AIB1 alleles with 26 or fewer glutamine repeats are not associated with increased breast cancer risk in the general population

peripheral cohort plasma pcr nested plasma
Discrimination of three mutational events that result in a disruption of the R122 primary autolysis site of the human cationic trypsinogen (PRSS1) by denaturing high performance liquid chromatography.

PMID 11734061 · PMC60523 · BMC genetics · 2001 · 7 claims · 3 setups

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DHPLC can readily discriminate the two known mutational events (c.365G>A and c.365~366GC>AT) that both cause the R122H mutation

genomic pcr independently pcr denaturing direct

Experiments

The functional landscape of alternative splicing in hematopoietic lineage commitment.

Tumour-intrinsic features shape T cell differentiation through precursor to symptomatic multiple myeloma.

Antigen specificity of clonally enriched CD8(+) T cells in multiple sclerosis.

Multiomics combined drugs to explore the potential mechanism and treatment of ankylosing spondylitis.

Innate antiviral and immune functions associated with the HIV reservoir decay after anti-PD-1 therapy.

α4 Integrin blockade impairs CD8+ T cell neuroimmune surveillance following SIV infection.

Metabolic quiescence of naive-like memory T cells precedes and maintains antigen-specific T cell memory.

A new chromosome-level genome assembly for western painted turtle Chrysemys picta bellii, a model for extreme physiological adaptations.

Metabolic Adaptation of CD8⁺ T Cells Limits the Efficacy of Fatty Acid Oxidation Inhibition in Type 1 Diabetes.

Comprehensive cellular analysis with single-nucleus RNA-seq of archived PAXgene whole blood samples.

Single-Cell Multi-Tissue T Cell Clonal Dynamics Reveal Distinct Immune Coercion Landscapes in MSI and MSS Colorectal Cancer.

Integrated transcriptome and single-cell sequencing analysis identify blood-pancreas shared lncRNA biomarkers in new-onset T2DM.

Single-cell and spatial profiling of peripheral blood and synovium unveils pro-arthritis CNBP(+) myeloid cells.

Single-cell epigenetic and transcriptomic states across the continuum of monoclonal B cell lymphocytosis to chronic lymphocytic leukemia.

TBL1X/TBL1XR1 govern β-cell identity through a PAX6-containing gene regulatory network.

pmid-42030936

Enforced MYC expression directs a distinct transcriptional state during plasma cell differentiation.

Early days: genomics and human responses to infection.

Polymorphic repeat in AIB1 does not alter breast cancer risk.

Discrimination of three mutational events that result in a disruption of the R122 primary autolysis site of the human cationic trypsinogen (PRSS1) by denaturing high performance liquid chromatography.