Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• The Molecular and Functional Landscape of Resistance to FOLFIRI Chemotherapy in Metastatic Colorectal Cancer.

  PMID 40981426 · PMC12877753 · Cancer discovery · 2026 · 8 claims · 7 setups

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  FOLFIRI-resistant PDX tumors show transcriptional upregulation of innate immunity and mitochondrial metabolism genes and reduced expression of DNA polymerase POLD1

  mcrc pdx patients patient-derived drug whole-exome bulk

• Optimizing data-driven excellence: Canada's approach to using pathogen test datasets for quality control, pipeline development and training initiatives.

  PMID 41591806 · PMC12847982 · Microbial genomics · 2026 · 8 claims · 5 setups

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  Standardized SARS-CoV-2 test datasets (Illumina and Nanopore) were developed as benchmarks for validating sequencing/bioinformatics pipelines across Canadian public health labs

  sars-cov-2 extracted nasopharyngeal bioinformatic whole-genome triplex extraction

• Gut microbiome signatures associated with depression and obesity.

  PMID 41615149 · PMC13011431 · mSystems · 2026 · 8 claims · 4 setups

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  Taxonomic gut microbiome profiles classify depressed vs non-depressed subjects with a balanced accuracy of 0.90 using machine learning

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• Metagenomic Assessment of Full-Scale Wastewater Treatment Plants Identifies Sentinel Antibiotic Resistance Gene Families for Monitoring Reclaimed Wastewater and Treated Sludge.

  PMID 41636304 · PMC12918712 · Environmental science & technology · 2026 · 7 claims · 6 setups

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  Reclaimed effluents show lower AMR exposure (<0.5 ARGs/cell) than typically reported for secondary effluents

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• The genomic diversity of SARS-CoV-2 Omicron lineages collected during routine sentinel surveillance in Tanzania between November 2022 and July 2023.

  PMID 41688918 · PMC13011721 · BMC genomics · 2026 · 8 claims · 5 setups

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  Seven Omicron Nextstrain clades were identified among Tanzanian sequences, with clades 22F (XBB*) and 22E (BQ.1) predominant, comprising 56.3% and 21.35% of samples respectively

  nasal sars-cov-2-positive multiplexed tanzanian rt-qpcr whole-genome bioinformatic

• WEPP: Phylogenetic placement achieves near-haplotype resolution in wastewater-based epidemiology.

  PMID 41911220 · PMC13048486 · PLoS computational biology · 2026 · 8 claims · 5 setups

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  WEPP is a pathogen-agnostic pipeline that uses phylogenetic placement of sequencing reads onto mutation-annotated trees (MATs) to identify candidate haplotypes and estimate their abundances

  sars-cov-2 mutation-annotated simulated synthetic real-world

• Transposable elements are driving rapid adaptation of Enterococcus faecium.

  PMID 42020750 · PMC13216065 · Nature · 2026 · 8 claims · 8 setups

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  E. faecium has the highest IS density among ESKAPEE pathogens, dominated by replicative ISL3 family elements

  eskapee faecium ncbi single-hospital large-scale chromosome core

• nf-core/viralmetagenome: A novel pipeline for untargeted viral genome reconstruction.

  PMID 42057295 · PMC13141149 · Bioinformatics (Oxford, England) · 2026 · 8 claims · 5 setups

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  nf-core/viralmetagenome is a Nextflow pipeline that automates untargeted reconstruction and variant analysis of eukaryotic DNA and RNA viruses from short-read metagenomic or hybridisation-capture data.

  real simulated seven pipeline metagenomic simulated clinical

• MicroRNA Enrichment and Docking-Based Evaluation of Ilomastat Targeting of MMP-2 in Esophageal Squamous Cell Carcinoma: Insights from a South African Cohort.

  PMID 42158110 · PMC13181172 · Computational and structural biotechnology journal · 2026 · 7 claims · 5 setups

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  The miR-29 family inhibits MMP-2 and represents a key regulatory axis in tumor invasion

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• Tumor and Immune Dynamics Following Sequential CDK4/6 and PD-1 Inhibition: Results from a Phase 2 Study in Dedifferentiated Liposarcoma.

  PMID 41325133 · PMC13037771 · Cancer research communications · 2026 · 7 claims · 4 setups

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  A palbociclib lead-in prior to retifanlimab produced a high rate of immune-related adverse events, leading to halted enrollment.

  tumor peripheral patients single-cell high-parameter clinical

• Autologous cell therapy with CD133+ bone marrow-derived stem cells for Asherman Syndrome: a phase 1/2 trial.

  PMID 41484096 · PMC12852688 · Nature communications · 2026 · 8 claims · 8 setups

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  Autologous CD133+ BMDSC therapy is safe and well tolerated in AS patients, with no treatment-related serious adverse events over 15-month follow-up

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• FOXA1 mutations co-opt nascent transcription factor networks in partnership with androgen receptor to enhance prostate tumorigenicity.

  PMID 41621066 · PMC13050545 · Cell reports · 2026 · 8 claims · 8 setups

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  FOXA1 mutations in a 874-tumor cohort cluster into missense, in-frame indel, and truncation subgroups, with indels concentrated at residues M253/E255

  prostate targeted single-nucleus scatac-seq

• Discovery and Evaluation of Biomarkers for Triple-Negative Breast Cancer Subtypes Uncovers Patient Stratification and Targeted Therapeutic Strategies.

  PMID 41671401 · PMC13176827 · Cancer research · 2026 · 7 claims · 8 setups

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  A set of basal identity genes (SMA/ACTA2, TAGLN, TPM2) defined by scRNA-seq analysis enables subclassification of TNBC into a subgroup termed true basal TNBC (tB-TNBC)

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• Development of a potent monoclonal antibody for treatment of human metapneumovirus infections.

  PMID 41680141 · PMC13013820 · Nature communications · 2026 · 8 claims · 8 setups

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  4F11 is a highly potent neutralizing mAb against HMPV with in vitro and in vivo efficacy

  splenocytes vero recombinant hmpv fluorescent plaque biolayer

• Unravelling Synaptic and Metabolic Mechanisms of Cognitive Resilience in Asymptomatic Alzheimer's Disease Across Two Alzheimer's Disease Cohorts.

  PMID 41723778 · PMC12996523 · Cellular and molecular neurobiology · 2026 · 6 claims · 6 setups

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  Integrating DEG, DET, and DUT analyses (rather than DEGs alone) provides a more comprehensive view of the molecular mechanisms of AsymAD, since some genes/transcripts are only detected by transcript-level methods.

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• Splice-switching of the oncogenic BCS1L isoform suppresses ovarian cancer progression by disrupting mitochondrial function.

  PMID 41771836 · PMC13039997 · Cell death & disease · 2026 · 7 claims · 8 setups

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  BCS1L is alternatively spliced into a full-length isoform (BCS1L-L) and an exon 2-skipped short isoform (BCS1L-S)

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• Exploring the mechanism of action of abemaciclib in breast cancer through circulating chromatin fragments.

  PMID 41845059 · PMC13149665 · Communications medicine · 2026 · 8 claims · 5 setups

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  cfDNA concentrations are significantly higher in breast cancer patients than healthy donors and decline following abemaciclib therapy

  serum t47d edger-normalized cfdna proliferation pathway

• Single-cell mitophagy signature-based artificial intelligence model enhances prediction of prognosis and immunotherapy response in non-small-cell lung cancer.

  PMID 41851738 · PMC13112628 · Respiratory research · 2026 · 8 claims · 8 setups

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  A six-gene MRG panel (FOS, CANX, EIF4G1, CALCOCO2, HSP90AB1, PRKAR1A) was selected via LASSO regression as prognostic markers in NSCLC.

  nsclc tcga external immunotherapy single-cell bulk transcriptomic

• pmid-41907411

  PMID 41907411 · PMC13018899 · 8 claims · 8 setups

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  A malignant epithelial subpopulation (Cluster 0) with the highest CytoTRACE stemness potential and highest EMT activity exists in ESCC scRNA-seq data

  escc degs eca109 kyse180 scrna-seq machine immunohistochemistry

• An open-source representation for 2-DE-centric proteomics and support infrastructure for data storage and analysis.

  PMID 18179696 · PMC2231339 · BMC bioinformatics · 2008 · 8 claims · 4 setups

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  AGML 2.0 is a comprehensive XML representation for 2-DE experiments comprising identification, protocol (MI2DG), and gel sections

  general gel excised clinical 2-dimensional differential mass