Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

Publications 1.3k Datasets 392.5k Experiments 42

System / cell line: cd31+ ✕ Clear

Notch3 regulates pericyte phenotypic plasticity in colorectal cancer.

PMID 41618002 · PMC12960917 · Communications biology · 2026 · 8 claims · 8 setups

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Murine tumor pericytes originate from normal tissue-resident pericytes that proliferate inside tumors

aom crc pdgfrβ-creert2 notch3-creert2 scrna-seq facs lineage
Endothelial PDGF Signaling Dysregulation Impairs Testicular Interstitial Homeostasis in Diabetes.

PMID 41643060 · PMC13073339 · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026 · 8 claims · 7 setups

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Testicular endothelial cells (TECs) function as a central signaling hub coordinating intercellular communication within the human testicular interstitium

testicular testis leydig diabetic single-cell integrative cell-cell
Base barrier cells provide compartmentalization of choroid plexus, brain and CSF.

PMID 41680326 · PMC12971494 · Nature neuroscience · 2026 · 8 claims · 8 setups

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A distinct fibroblast population, ChP base barrier cells (BBCs, formerly type II fibroblasts), exists at the base of the choroid plexus, separate from ChP stromal (type I) fibroblasts

lateral brain mesp1-cre chp scrna-seq multiplex immunofluorescence
Vγ1 γδ T cells steer airway macrophages toward a profibrotic response in an autochthonous lung cancer mouse model.

PMID 41779856 · PMC12959402 · Science advances · 2026 · 7 claims · 6 setups

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Lung tumors drive expansion of both CD27+ and CD27- pulmonary γδ T cells, which acquire distinct spatial and phenotypic changes in the tumor microenvironment

spc-cre+ microdissected sorted merged flow confocal single-cell
Sensitizer-Induced Basophils Accelerate Skin Re-Epithelialization via IL-4/IL-13-Mediated Macrophage Polarization.

PMID 41787818 · PMC13139821 · Allergy · 2026 · 8 claims · 8 setups

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Basophils accumulate in wounded and oxazolone (OXA)-sensitized skin, peaking around day 3–6 post-injury

skin ear dorsal mcpt8-ct single-cell flow rt-qpcr
Single-cell landscape of piglet lung response with Actinobacillus pleuropneumoniae.

PMID 41843736 · PMC13014559 · Virulence · 2026 · 8 claims · 8 setups

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scRNA-seq of piglet lungs identified 18 cell subpopulations with distinct phenotypes in infected vs control lungs

piglet monocytes bronchoalveolar single-cell hematoxylin-and-eosin immunohistochemistry
Epigenetic context defines the transcriptional activity of canonical and noncanonical NF-κB signaling in pancreatic cancer.

PMID 41844578 · PMC13039881 · Cell death discovery · 2026 · 8 claims · 8 setups

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TNFα is the primary activator of canonical NF-κB signaling via RELA in PDAC

pdac patient-derived aspc-1 l3.6pl single-cell bulk multiplex
Distinct origins and niches determine the cellular responsiveness of CNS macrophages after repopulation.

PMID 41851525 · PMC13132723 · Nature immunology · 2026 · 8 claims · 8 setups

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Microglia repopulate rapidly and exclusively cell-autonomously from surviving microglia after CSF-1R inhibitor (BLZ945) depletion.

brain cerebral cd11b+cd45int-hi leptomeninges flow confocal single-cell
Single-cell multiomics uncovers an endothelial mechanosensitive PIEZO1-IL-33 axis driving pulmonary fibrosis.

PMID 41862476 · PMC13004862 · Nature communications · 2026 · 7 claims · 8 setups

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Mechanical stress (MS) signaling is significantly elevated in endothelial cells (ECs) from IPF patients and correlates with fibrosis severity and lung function decline

lung cd31+ single-nucleus scissor meta-analysis
Reprogramming of stroma-derived chemokine networks drives the loss of tissue organization in nodal B cell lymphoma.

PMID 41882179 · PMC13035477 · Nature cancer · 2026 · 8 claims · 8 setups

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LN-resident stromal cells (FRCs, BECs, LECs) drive chemokine-based lymphocyte zonation, and disruption of this system underlies the loss of tissue organization in nodal B cell lymphoma

rln healthy bulk fl-ln scrna-seq multiplex bulk
Single-cell transcriptomic analyses reveal angiogenic vascular responses to chronic cerebral hypoperfusion.

PMID 41907427 · PMC13019947 · iScience · 2026 · 8 claims · 8 setups

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A distinct endothelial tip cell subcluster emerges and expands in the brain after chronic cerebral hypoperfusion (ACAS)

brain mbmec acas single-cell laser immunostaining
The heterogeneity of dermal mesenchymal cells reproduced in skin equivalents regulates barrier function and elasticity.

PMID 41922844 · PMC13172354 · EMBO reports · 2026 · 7 claims · 8 setups

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Tricellular communication among epidermal keratinocytes, dermal fibroblasts, and vascular endothelial cells (EDV model) is required for normal epidermal organization, endothelial tube formation, and collagen deposition compared to models lacking one or more cell types.

hse edv h&e sirius immunohistochemistry
Single-cell spatiotemporal dissection of the human maternal-fetal interface.

PMID 41951740 · PMC13149032 · Nature · 2026 · 8 claims · 8 setups

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Generated a comprehensive single-cell multiomic and spatial atlas of the human maternal-fetal interface from early gestation to term

decidua maternal-fetal pseudobulk trophoblast paired genotype snatac-seq
Single-cell and spatial transcriptomics analyses reveal tumor microenvironment-driven proliferation of NF2-associated vestibular schwannomas.

PMID 41957607 · PMC13200446 · Journal of neuroinflammation · 2026 · 8 claims · 7 setups

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NF2-VS tumors comprise 12 major cell lineages with distinct TME composition between Gardner and Wishart phenotypes

vestibular fresh nf2-vs fibroblast scrna-seq spatial multiplex
ERG is a regulator of dynamic and reversible endothelial plasticity.

PMID 42067854 · PMC13135260 · Genome medicine · 2026 · 7 claims · 8 setups

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Loss of ERG initiates a progressive EndMT program in which endothelial identity is lost rapidly (by 24 h) before mesenchymal identity, barrier dysfunction, and enhanced migration emerge later (by 72 h)

telohaec huvec atac-seq rna-seq western
Endothelial Adgrl2 Expression and Alternative Splicing Controls the Cerebrovasculature.

PMID 41876233 · PMC13108381 · The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026 · 8 claims · 5 setups

Has reproduction · 75

Endothelial cell-specific deletion of Adgrl2 impairs cerebrovascular integrity in mice

wild-type cortex brain single-molecule single-cell immunohistochemistry
The identification of a Distinct Astrocyte Subtype that Diminishes in Alzheimer's Disease.

PMID 38502590 · PMC11567244 · Aging and disease · 2024 · 7 claims · 7 setups

Has reproduction · 57

A distinct astrocyte subpopulation marked by low GFAP, AQP4+, and CD63+ expression exists in normal brain and is functionally enriched for Aβ clearance and tau protein binding

hippocampus prefrontal astrocyte frontal single-nuclei gene cell-cell
Vascular adhesion protein-1 defines a unique subpopulation of human hematopoietic stem cells and regulates their proliferation.

PMID 34719737 · PMC8629906 · Cellular and molecular life sciences : CMLS · 2021 · 7 claims · 8 setups

Has reproduction · 50

VAP-1 is expressed on a subset of human HSC and on bone marrow vasculature forming a hematogenic niche

bone sorted cord femur flow bulk single-cell
Assessing personalized molecular portraits underlying endothelial-to-mesenchymal transition within pulmonary arterial hypertension.

PMID 39462326 · PMC11513636 · Molecular medicine (Cambridge, Mass.) · 2024 · 8 claims · 8 setups

Has reproduction · 81

scRNA-seq of PAH and control lung tissue identifies nine distinct cell populations with high heterogeneity in composition, function, distribution, and communication

lung pah scrna-seq-derived endothelial scrna-seq bulk cell-cell
Intrinsic genetic characteristics determine tumor-modifying capacity of fibroblasts: matrix metalloproteinase-3 5A/5A genotype enhances breast cancer cell invasion.

PMID 17922906 · PMC2242664 · Breast cancer research : BCR · 2007 · 8 claims · 8 setups

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Tumor-derived fibroblasts promote higher levels of breast cancer cell invasion than normal fibroblasts

breast conditioned mda-mb-468 genomic invasion immunofluorescence pcr-rflp

Experiments

Notch3 regulates pericyte phenotypic plasticity in colorectal cancer.

Endothelial PDGF Signaling Dysregulation Impairs Testicular Interstitial Homeostasis in Diabetes.

Base barrier cells provide compartmentalization of choroid plexus, brain and CSF.

Vγ1 γδ T cells steer airway macrophages toward a profibrotic response in an autochthonous lung cancer mouse model.

Sensitizer-Induced Basophils Accelerate Skin Re-Epithelialization via IL-4/IL-13-Mediated Macrophage Polarization.

Single-cell landscape of piglet lung response with Actinobacillus pleuropneumoniae.

Epigenetic context defines the transcriptional activity of canonical and noncanonical NF-κB signaling in pancreatic cancer.

Distinct origins and niches determine the cellular responsiveness of CNS macrophages after repopulation.

Single-cell multiomics uncovers an endothelial mechanosensitive PIEZO1-IL-33 axis driving pulmonary fibrosis.

Reprogramming of stroma-derived chemokine networks drives the loss of tissue organization in nodal B cell lymphoma.

Single-cell transcriptomic analyses reveal angiogenic vascular responses to chronic cerebral hypoperfusion.

The heterogeneity of dermal mesenchymal cells reproduced in skin equivalents regulates barrier function and elasticity.

Single-cell spatiotemporal dissection of the human maternal-fetal interface.

Single-cell and spatial transcriptomics analyses reveal tumor microenvironment-driven proliferation of NF2-associated vestibular schwannomas.

ERG is a regulator of dynamic and reversible endothelial plasticity.

Endothelial Adgrl2 Expression and Alternative Splicing Controls the Cerebrovasculature.

The identification of a Distinct Astrocyte Subtype that Diminishes in Alzheimer's Disease.

Vascular adhesion protein-1 defines a unique subpopulation of human hematopoietic stem cells and regulates their proliferation.

Assessing personalized molecular portraits underlying endothelial-to-mesenchymal transition within pulmonary arterial hypertension.

Intrinsic genetic characteristics determine tumor-modifying capacity of fibroblasts: matrix metalloproteinase-3 5A/5A genotype enhances breast cancer cell invasion.