Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

Publications 1.3k Datasets 392.5k Experiments 40

System / cell line: pd-1 ✕ Clear

Identifying Molecular Subtypes and 6-Gene Prognostic Signature Based on Hypoxia for Optimizing Targeted Therapies in Non-Small Cell Lung Cancer.

PMID 35509605 · PMC9058021 · International journal of general medicine · 2022 · 8 claims · 8 setups

Has reproduction · 59

NSCLC samples can be classified into two molecular subtypes (C1 and C2) based on hypoxia-related gene expression via consensus clustering

tcga-nsclc geo bulk microarray unsupervised
5-HT reuptake blockade induces pyroptosis in BRAF(V600E)-mutated melanomas via remodeling histone serotonylation.

PMID 41494533 · PMC12866116 · Cell reports. Medicine · 2026 · 8 claims · 8 setups

Has reproduction · 40

High-throughput screening of 90 FDA-approved antidepressants identifies PH as an alternative therapeutic for BRAF V600E-mutated melanoma

braf a375 gfp-tph1-overexpressing yumm1.7 high-throughput ic50 xenograft
Machine learning developed an intratumor heterogeneity signature for predicting clinical outcome and immunotherapy benefit in bladder cancer.

PMID 39100839 · PMC11291408 · Translational andrology and urology · 2024 · 8 claims · 8 setups

Has reproduction · 40

An integrative machine learning procedure (10 methods, 101 algorithm combinations) identified an Enet (alpha=0.2)-based intratumor heterogeneity-related signature (IRS) with the highest average C-index (0.69) across TCGA and GEO cohorts

bladder skin bulk integrative immune
Vitamin C Conditioning Generates Tumor-Targeting CAR T Cells with Superior Cytotoxicity and Fitness in a Posttransplant Lymphoproliferative Disorder Tumor Model.

PMID 41416402 · PMC13136873 · Molecular cancer therapeutics · 2026 · 8 claims · 8 setups

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VitC conditioning enhances transduction efficiency and proliferative capacity, yielding a higher yield of CD4+ and CD8+ CAR19-Ts

cd3+ je6-1 car19-ts coculture flow nf-κb cytotoxicity
A pan-cancer single cell landscape reveals heterogeneity and functional diversity of double-negative T cells.

PMID 41484771 · PMC12882460 · Molecular cancer · 2026 · 7 claims · 5 setups

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Integration of pan-cancer scRNA-seq data yields a comprehensive single-cell atlas of 157,025 high-quality DNT cells across 23 cancer types.

tumor dnt ffpe mc38 scrna-seq tcr multiplex
Dynamics of lung-infiltrating virus-specific T cells associated with age-dependent SARS-CoV-2 pneumonia severity.

PMID 41533733 · PMC12829949 · PLoS pathogens · 2026 · 8 claims · 8 setups

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Aged Nr4a3-Tocky mice develop more severe pneumonia and delayed body weight recovery after SARS-CoV-2 infection than adult mice

nr4a3-tocky bronchoalveolar lung left viral histopathology immunohistochemistry
Host-derived interleukin-1α drives tumor immunosuppression by reprogramming tumor-associated myeloid cells.

PMID 41547846 · PMC12910057 · NPJ breast cancer · 2026 · 8 claims · 8 setups

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Deletion of host Il1α causes rejection/regression of transplanted breast tumors

h605 pymt tumor-infiltrating two-week orthotopic flow single-cell
PRDM1+ Malignant Cells Mediate an Immunosuppressive Landscape and Resistance to Neoadjuvant Chemoradiotherapy and Immunotherapy in Esophageal Squamous Cell Carcinoma.

PMID 41556358 · PMC13042517 · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026 · 8 claims · 8 setups

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A PRDM1+ malignant epithelial cell subcluster (Epi_C4) is enriched in NMPR patients and is associated with nICRT treatment resistance

locally escc pd-1 kyse-30 single-arm scrna-seq bulk
Ex Vivo Immuno-Oncology Platform Reveals Spatial T-cell Infiltration Patterns Linked to ATR Inhibition Responses in High-Grade Serous Ovarian Cancer.

PMID 41563843 · PMC7618831 · Cancer immunology research · 2026 · 8 claims · 8 setups

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iPDCs cultured on human omentum gel (OmGel) recapitulate tumor genomic and histologic characteristics while retaining intratumoral immune cells

formalin-fixed blood dissociated ipdcs histopathology whole-exome flow
A pan-cancer single-cell transcriptomic atlas of human bone metastases.

PMID 41619722 · PMC12923970 · Cell reports. Medicine · 2026 · 8 claims · 8 setups

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Constructed a pan-cancer single-cell transcriptomic atlas of 62 human bone metastases (predominantly spinal) across 13 primary cancer types, with paired primary tumor and normal bone marrow samples.

bone paired plasmacytoma malignant scrna-seq ihc infercnv
ISG15-driven immune modulation and tumor progression in breast cancer metastasis: insights from single-cell and spatial transcriptomics.

PMID 41639695 · PMC12958617 · BMC medicine · 2026 · 8 claims · 8 setups

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CSC proportion is elevated in lymph node metastatic tumor tissue (BRCA_LNMT) compared to primary tumor (BRCA_PT)

4t1 brca tcga-brca top single-cell spatial bulk
Identification and Validation of an Autophagy-Related Gene Signature for Prognostic Prediction and Immunotherapy Response in Esophageal Squamous Cell Carcinoma.

PMID 41681864 · PMC12897147 · Cancers · 2026 · 8 claims · 8 setups

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A 4-ARG prognostic model (NBEA, CLOCK, NLRX1, MAGEA3) built via stepwise multivariate Cox regression stratifies ESCC patients into high- and low-risk groups with significantly different survival.

escc gse53625 gse160269 imvigor210 microarray univariate single-cell
Single-cell mapping of cholesterol metabolism reveals FDPS as a therapeutic vulnerability in hepatocellular carcinoma.

PMID 41706364 · PMC12916967 · Cellular oncology (Dordrecht, Netherlands) · 2026 · 7 claims · 8 setups

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Cholesterol metabolic activity is markedly elevated in HCC tumors and in immune checkpoint blockade (ICB) non-responders, with pronounced intratumoral heterogeneity across malignant cell subpopulations

hcc tcga-lihc malignant hepa1-6 scrna-seq bulk hdwgcna
The transcription factor EHF promotes the maturation and immunosuppression of conventional dendritic cells.

PMID 41730908 · PMC13039115 · Nature communications · 2026 · 8 claims · 8 setups

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EHF orchestrates an immunosuppressive maturation program in cDC1s and cDC2s downstream of TLR7/8/9 sensing of self-nucleic acids

ehf facs-sorted dss-induced lethal cd4+
IFN signaling is associated with radiotherapy response in malignant peripheral nerve sheath tumors.

PMID 41766654 · PMC12948414 · The Journal of clinical investigation · 2026 · 8 claims · 8 setups

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MPNST cells are more radioresistant than benign plexiform neurofibroma (pNF) cells in vitro

mpnst st88-14 nf9511.b jh-2-002 flow fractionated bulk
VISTA drives pancreatic tumor progression through modulation of the tumor-associated macrophage polarity.

PMID 41776161 · PMC13194722 · Nature communications · 2026 · 8 claims · 8 setups

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VISTA deficiency significantly impairs PDAC tumor growth and prolongs survival in murine orthotopic models

pan02 cd45+ tumor mice orthotopic pharmacological flow
Tipping the balance in autoimmune disease.

PMID 18001485 · PMC2246277 · Genome biology · 2007 · 8 claims · 8 setups

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Human autoimmune diseases are fundamentally diseases of immune dysfunction, evidenced by predisposing genes being immune-function genes, some shared and some unique across MS, T1D, SLE, CD and RA

patients congenic nzm2410 mrl-lpr snp induced genetic
Metabolic adaptations rewire CD4(+) T cells in a subset-specific manner in human critical illness with and without sepsis.

PMID 41540263 · PMC12864044 · Nature immunology · 2026 · 8 claims · 7 setups

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CD4+ T cells in critical illness show subset-specific metabolic plasticity, with regulatory T (Treg) cells preferentially acquiring glycolytic capacity

pbmc-derived peripheral cd4+ puromycin-incorporation complete expression
CD38 expression by neonatal human naive CD4+ T cells shapes their distinct metabolic and tolerogenic properties.

PMID 41746743 · PMC13078883 · The Journal of clinical investigation · 2026 · 8 claims · 8 setups

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CD38 is markedly more highly expressed on cord blood (CB) naive CD4+ T cells than adult blood (AB) naive CD4+ T cells, with an age-dependent gradient from fetal to pediatric life.

pbmcs sorted scrna-seq naive flow bulk compass
DLX2 marks an immunosuppressive dendritic-cell program that reshapes cytotoxic immunity and marks a tolerogenic microenvironment in lung adenocarcinoma.

PMID 41761000 · PMC13043845 · Discover oncology · 2026 · 8 claims · 8 setups

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Neuroactive ligand–receptor signaling is among the most significantly upregulated pathways in LUAD relative to normal lung tissue.

tcga-luad tcga luad dendritic-cell bulk survival pan-cancer

Experiments

Identifying Molecular Subtypes and 6-Gene Prognostic Signature Based on Hypoxia for Optimizing Targeted Therapies in Non-Small Cell Lung Cancer.

5-HT reuptake blockade induces pyroptosis in BRAF(V600E)-mutated melanomas via remodeling histone serotonylation.

Machine learning developed an intratumor heterogeneity signature for predicting clinical outcome and immunotherapy benefit in bladder cancer.

Vitamin C Conditioning Generates Tumor-Targeting CAR T Cells with Superior Cytotoxicity and Fitness in a Posttransplant Lymphoproliferative Disorder Tumor Model.

A pan-cancer single cell landscape reveals heterogeneity and functional diversity of double-negative T cells.

Dynamics of lung-infiltrating virus-specific T cells associated with age-dependent SARS-CoV-2 pneumonia severity.

Host-derived interleukin-1α drives tumor immunosuppression by reprogramming tumor-associated myeloid cells.

PRDM1+ Malignant Cells Mediate an Immunosuppressive Landscape and Resistance to Neoadjuvant Chemoradiotherapy and Immunotherapy in Esophageal Squamous Cell Carcinoma.

Ex Vivo Immuno-Oncology Platform Reveals Spatial T-cell Infiltration Patterns Linked to ATR Inhibition Responses in High-Grade Serous Ovarian Cancer.

A pan-cancer single-cell transcriptomic atlas of human bone metastases.

ISG15-driven immune modulation and tumor progression in breast cancer metastasis: insights from single-cell and spatial transcriptomics.

Identification and Validation of an Autophagy-Related Gene Signature for Prognostic Prediction and Immunotherapy Response in Esophageal Squamous Cell Carcinoma.

Single-cell mapping of cholesterol metabolism reveals FDPS as a therapeutic vulnerability in hepatocellular carcinoma.

The transcription factor EHF promotes the maturation and immunosuppression of conventional dendritic cells.

IFN signaling is associated with radiotherapy response in malignant peripheral nerve sheath tumors.

VISTA drives pancreatic tumor progression through modulation of the tumor-associated macrophage polarity.

Tipping the balance in autoimmune disease.

Metabolic adaptations rewire CD4(+) T cells in a subset-specific manner in human critical illness with and without sepsis.

CD38 expression by neonatal human naive CD4+ T cells shapes their distinct metabolic and tolerogenic properties.

DLX2 marks an immunosuppressive dendritic-cell program that reshapes cytotoxic immunity and marks a tolerogenic microenvironment in lung adenocarcinoma.