Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

Publications 1.3k Datasets 392.5k Experiments 353

System / cell line: qpcr ✕ Clear

Loss of Ezh2 promotes M2-like macrophage polarization in hepatocellular carcinoma.

PMID 41869562 · PMC12999353 · iScience · 2026 · 8 claims · 7 setups

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Hepa1-6 conditioned media (CM) induces M2-like polarization of BMDMs in a dose-dependent manner

bmdms rt-qpcr western flow
Chikungunya virus persists in joint-associated macrophages and promotes chronic disease in mice.

PMID 41922840 · PMC13171603 · Nature microbiology · 2026 · 8 claims · 7 setups

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Inflammatory macrophages accumulate in joint-associated tissue during the chronic stage of CHIKV infection and show an activated, pro-inflammatory, MHC-II+ transcriptional programme

ankle ipsilateral computational pfa-fixed rt-qpcr single-cell gene
SARS-CoV-2 infection during the first trimester leads to profound immune dysregulation at the maternal-fetal interface despite limited virus detection in placental tissues.

PMID 41974725 · PMC13249863 · Nature communications · 2026 · 8 claims · 8 setups

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SARS-CoV-2 rarely infects villous and decidual placental tissues in the first trimester despite maternal infection

villous maternal rt-qpcr fluorescence indirect
Fundamental and unique roles of PLAC1 in the regulation of rat and human trophoblast cell development.

PMID 42007670 · PMC13245914 · Development (Cambridge, England) · 2026 · 8 claims · 9 setups

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Plac1 transcripts are expressed in the junctional zone of the rat placenta and in intrauterine invasive trophoblast cells

placenta placentation uterine-placental plac1 rt-qpcr situ single-cell
Entry, replication and innate immunity evasion of BANAL-236, a SARS-CoV-2-related bat virus, in Rhinolophus and human cells.

PMID 42008572 · PMC13108884 · PLoS pathogens · 2026 · 8 claims · 8 setups

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BANAL-236 did not replicate in wild-type Rhinolophus (RFe) cell lines

rfe caco-2 293t rhinolophus rt-qpcr viral flow
An MNase-ChIP-Seq Protocol to Profile Histone Modifications at a DNA Break in Yeast.

PMID 41874159 · PMC13010634 · Methods and protocols · 2026 · 6 claims · 5 setups

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MNase-ChIP-seq, combining MNase-based chromatin fragmentation with ChIP and NGS, is a robust protocol to map histone PTMs and their genome-wide distribution after induction of a single HO-generated DSB in yeast

cerevisiae extracted crosslinked rt-qpcr qpcr-based mnase-chip-seq
Expression analysis of candidate breast tumour suppressor genes on chromosome 16q.

PMID 16280054 · PMC1410740 · Breast cancer research : BCR · 2005 · 8 claims · 7 setups

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None of the six candidate genes (CBFA2T3, TERF2, TERF2IP, FBXL8, LRRC29, FANCA) showed inactivating mutations or expression differences clearly associated with 16q LOH status

breast quantitative fragment gene-expression
Identification of novel regulatory factor X (RFX) target genes by comparative genomics in Drosophila species.

PMID 17875208 · PMC2375033 · Genome biology · 2007 · 8 claims · 4 setups

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A subset of C. elegans DAF-19 target genes have Drosophila homologs that are also regulated by dRFX, showing conservation of the RFX regulatory cascade between the two species.

drosophila genome melanogaster real-time comparative gfp
Widespread dysregulation of MiRNAs by MYCN amplification and chromosomal imbalances in neuroblastoma: association of miRNA expression with survival.

PMID 19924232 · PMC2773120 · PloS one · 2009 · 8 claims · 5 setups

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37 miRNAs are significantly differentially expressed between MYCN-amplified (MNA) and non-MNA neuroblastoma tumors, suggesting direct or indirect regulation by MYCN

neuroblastoma shep-tet21 stem-loop array tlda
Epidemiology and phylogenomic characterization of the Clade IIb C.1 Mpox outbreak in Phnom Penh, Cambodia (2023-2024).

PMID 41575511 · PMC12978180 · Emerging microbes & infections · 2026 · 8 claims · 8 setups

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All Cambodian Mpox genomes belong to lineage C.1, nested within Clade IIb

skin mpxv-positive raw cambodian real-time viral bioinformatic
Annexin A13 Protects Against Acute Kidney Injury by Inactivating TGF-β/Smad3 Signaling.

PMID 41486854 · PMC12915081 · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026 · 8 claims · 8 setups

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ANXA13 is selectively downregulated in the kidneys of AKI patients and IRI- or cisplatin-induced AKI mice, primarily in proximal tubular cells

kidney aki renal hek293t rna-seq immunohistochemistry serum
Heterozygous ADAR mutant mice exhibit RNA sensing-dependent neuroinflammation and phenotypes associated with Aicardi-Goutières syndrome.

PMID 41704749 · PMC12907846 · iScience · 2026 · 8 claims · 8 setups

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A heterozygous Adar G1007R (mouse G956R/G567) mouse model recapitulates the genetic and inflammatory features of human ADAR G1007R AGS patients

brain computational coronal adar1 real-time bulk ingenuity
An optimized translating ribosome affinity purification protocol for low-abundance Drosophila tissues.

PMID 42028032 · PMC13099348 · iScience · 2026 · 8 claims · 8 setups

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An optimized TRAP protocol enables sensitive and specific isolation of ribosome-bound mRNAs from very limited Drosophila material

flies fly thoraces larvae tapestation rt-qpcr rna-seq
Recovery of bisulfite-converted genomic sequences in the methylation-sensitive QPCR.

PMID 17439964 · PMC1888819 · Nucleic acids research · 2007 · 8 claims · 7 setups

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Bisulfite treatment causes DNA strand breakage (via abasic site formation and beta-elimination) in addition to cytosine deamination.

genomic synthetic bisulfite-treated cloned methylation-sensitive quantitative gel
Disrupted PGR-B and ESR1 signaling underlies defective decidualization linked to severe preeclampsia.

PMID 34709177 · PMC8553341 · eLife · 2021 · 8 claims · 6 setups

Has reproduction · 78

A 120-gene transcriptomic fingerprint encoding defective decidualization is present in decidua of women who developed sPE in a prior pregnancy

endometrial proteins bulk rt-qpcr immunofluorescence
Tbx5 drives Aldh1a2 expression to regulate a RA-Hedgehog-Wnt gene regulatory network coordinating cardiopulmonary development.

PMID 34643182 · PMC8555986 · eLife · 2021 · 7 claims · 8 setups

Has reproduction · 84

Tbx5 directly maintains Aldh1a2 expression in the foregut lateral plate mesoderm via an evolutionarily conserved intronic enhancer

e9.5 xenopus bulk rt-qpcr whole-mount
Targeting the epigenome and the integrated stress response to normalize colorectal cancer subclonal plasticity and progression.

PMID 41963303 · PMC13181133 · Cell death & disease · 2026 · 8 claims · 8 setups

Has reproduction · 68

The integrated stress response (ISR) induces CRC cell plasticity, subclonal diversity, and tumor progression in stress-surviving cells

ht29-derived ht29 nod rna-seq faire-qpcr chip-seq
Plant Soft Rot Development and Regulation from the Viewpoint of Transcriptomic Profiling.

PMID 32927917 · PMC7570247 · Plants (Basel, Switzerland) · 2020 · 8 claims · 6 setups

Has reproduction

Pba infection of tobacco causes massive transcriptomic reprogramming, with 8636 differentially expressed genes (DEGs) split between up- and downregulated genes.

tobacco potato rna-seq qpcr enzyme
β-Catenin activity induces an RNA biosynthesis program promoting therapy resistance in T-cell acute lymphoblastic leukemia.

PMID 36597789 · PMC9906382 · EMBO molecular medicine · 2023 · 8 claims · 8 setups

Has reproduction · 65

β-catenin binds directly to promoters of RNA processing, splicing, and ribosomal biogenesis genes in T-ALL cells

rpmi8402 chipseq chip-qpcr sequencing
Analysis of the Hypoxic Response in a Mouse Cortical Collecting Duct-Derived Cell Line Suggests That Esrra Is Partially Involved in Hif1α-Mediated Hypoxia-Inducible Gene Expression in mCCD(cl1) Cells.

PMID 35806266 · PMC9267015 · International journal of molecular sciences · 2022 · 8 claims · 7 setups

Has reproduction · 76

mCCD cl1 cells mount a broad transcriptional response to 24 h hypoxia (0.2% O2), with 3086 genes differentially expressed

mccd lines bulk rt-qpcr western

Experiments

Loss of Ezh2 promotes M2-like macrophage polarization in hepatocellular carcinoma.

Chikungunya virus persists in joint-associated macrophages and promotes chronic disease in mice.

SARS-CoV-2 infection during the first trimester leads to profound immune dysregulation at the maternal-fetal interface despite limited virus detection in placental tissues.

Fundamental and unique roles of PLAC1 in the regulation of rat and human trophoblast cell development.

Entry, replication and innate immunity evasion of BANAL-236, a SARS-CoV-2-related bat virus, in Rhinolophus and human cells.

An MNase-ChIP-Seq Protocol to Profile Histone Modifications at a DNA Break in Yeast.

Expression analysis of candidate breast tumour suppressor genes on chromosome 16q.

Identification of novel regulatory factor X (RFX) target genes by comparative genomics in Drosophila species.

Widespread dysregulation of MiRNAs by MYCN amplification and chromosomal imbalances in neuroblastoma: association of miRNA expression with survival.

Epidemiology and phylogenomic characterization of the Clade IIb C.1 Mpox outbreak in Phnom Penh, Cambodia (2023-2024).

Annexin A13 Protects Against Acute Kidney Injury by Inactivating TGF-β/Smad3 Signaling.

Heterozygous ADAR mutant mice exhibit RNA sensing-dependent neuroinflammation and phenotypes associated with Aicardi-Goutières syndrome.

An optimized translating ribosome affinity purification protocol for low-abundance Drosophila tissues.

Recovery of bisulfite-converted genomic sequences in the methylation-sensitive QPCR.

Disrupted PGR-B and ESR1 signaling underlies defective decidualization linked to severe preeclampsia.

Tbx5 drives Aldh1a2 expression to regulate a RA-Hedgehog-Wnt gene regulatory network coordinating cardiopulmonary development.

Targeting the epigenome and the integrated stress response to normalize colorectal cancer subclonal plasticity and progression.

Plant Soft Rot Development and Regulation from the Viewpoint of Transcriptomic Profiling.

β-Catenin activity induces an RNA biosynthesis program promoting therapy resistance in T-cell acute lymphoblastic leukemia.

Analysis of the Hypoxic Response in a Mouse Cortical Collecting Duct-Derived Cell Line Suggests That Esrra Is Partially Involved in Hif1α-Mediated Hypoxia-Inducible Gene Expression in mCCD(cl1) Cells.