Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Genomics meets nanoscience: probing genes and the cell nucleus at 10-9 meters.

  PMID 11897022 · PMC139022 · Genome biology · 2002 · 8 claims · 8 setups

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  Trans-splicing generates cell-specific protocadherin mRNAs in human neurons

  individual cancer pre-b saccharomyces reverse-transcriptase karyotypic spectral

• Construction and use of spotted large-insert clone DNA microarrays for the detection of genomic copy number changes.

  PMID 17406619 · PMC2688820 · Nature protocols · 2007 · 8 claims · 7 setups

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  Combining three human-optimized DOP-PCR primers before a secondary amino-labeled PCR increases array hybridization sensitivity and reproducibility sixfold compared to the standard 6MW DOP-PCR primer

  large-insert patients test genomic array-cgh manual automated

• The genome sequence of a hoverfly , Melangyna compositarum (Verrall, 1873) (Diptera: Syrphidae).

  PMID 41971599 · PMC13069379 · Wellcome open research · 2026 · 7 claims · 8 setups

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  A genome assembly was generated for a single male Melangyna compositarum hoverfly specimen (idMelComo1) as part of the Darwin Tree of Life project.

  melangyna barcoding high pacbio

• The genome sequence of a rove beetle, Tachyporus hypnorum (Fabricius, 1775) (Coleoptera: Staphylinidae).

  PMID 41993728 · PMC13080330 · Wellcome open research · 2026 · 6 claims · 8 setups

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  A chromosome-level genome assembly was generated for Tachyporus hypnorum, the first high-quality genome for the genus Tachyporus.

  tachyporus barcoding high pacbio

• The genome sequence of the Figwort Mason Wasp, Symmorphus gracilis (Brulle, 1832) (Hymenoptera: Vespidae).

  PMID 42109708 · PMC13153769 · Wellcome open research · 2026 · 6 claims · 8 setups

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  A chromosome-level genome assembly was generated for Symmorphus gracilis, comprising two haplotypes (220.03 Mb and 217.14 Mb), with haplotype 1 scaffolded to 6 chromosomal pseudomolecules

  symmorphus head genomic hifi barcoding hmw pacbio

• The genome sequence of the Red-necked Footman, Atolmis rubricollis (Linnaeus, 1758) (Lepidoptera: Erebidae).

  PMID 42148442 · PMC13173283 · Wellcome open research · 2026 · 7 claims · 8 setups

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  A chromosome-level genome assembly was generated for a female Atolmis rubricollis (Red-necked Footman) specimen as part of the Darwin Tree of Life project.

  atolmis barcoding pacbio hi-c

• The genome sequence of the Neglected Rustic moth, Xestia castanea (Esper, 1798) (Lepidoptera: Noctuidae).

  PMID 42148443 · PMC13179489 · Wellcome open research · 2026 · 8 claims · 8 setups

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  A genome assembly was generated for a female Xestia castanea individual comprising two haplotypes of 721.78 Mb and 685.53 Mb

  xestia pacbio assembled hi-c barcoding pacbio hi-c

• The genome sequence of the flat clown beetle, Hololepta plana (Sulzer, 1776) (Coleoptera: Histeridae).

  PMID 42255359 · PMC13237540 · Wellcome open research · 2026 · 8 claims · 8 setups

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  A chromosome-level genome assembly was produced for Hololepta plana (icHolPlan1) using the Darwin Tree of Life pipeline

  hololepta head abdomen hifi barcoding pacbio hi-c

• The genome sequence of the Club-Horned Wood Borer Wasp, Trypoxylon clavicerum Lepeletier de Saint Fargeau & Audinet-Serville, 1828 (Hymenoptera: Crabronidae).

  PMID 42255363 · PMC13237539 · Wellcome open research · 2026 · 8 claims · 8 setups

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  A genome assembly was generated for an individual female Trypoxylon clavicerum (Club-Horned Wood Borer Wasp) as part of the Darwin Tree of Life project

  trypoxylon pacbio assembled barcoding high pacbio

• Mutational analysis of mismatch repair genes, hMLH1 and hMSH2, in sporadic endometrial carcinomas with microsatellite instability.

  PMID 8609062 · PMC5921065 · Japanese journal of cancer research : Gann · 1996 · 5 claims · 2 setups

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  Mutations of hMLH1 or hMSH2 play only a limited role in the development of sporadic endometrial carcinomas.

  sporadic matched mutational

• VirPipe: an easy-to-use and customizable pipeline for detecting viral genomes from Nanopore sequencing.

  PMID 37129547 · PMC10191607 · Bioinformatics (Oxford, England) · 2023 · 8 claims · 1 setups

  Has reproduction · 83

  VirPipe is a new bioinformatics pipeline for detecting viral genomes from Nanopore or Illumina sequencing input with streamlined installation and customization.

  lung nanopore

• Immuno-detection by sequencing enables large-scale high-dimensional phenotyping in cells.

  PMID 29921844 · PMC6008431 · Nature communications · 2018 · 8 claims · 8 setups

  Has reproduction · 96

  ID-seq combines DNA-tagged antibodies with high-throughput sequencing to enable large-scale, high-dimensional, multiplexed (phospho-)protein phenotyping in fixed cell populations across many samples in parallel.

  epidermal id-seq immuno-pcr colony

• Species-Wide Phylogenomics of the Staphylococcus aureus Agr Operon Revealed Convergent Evolution of Frameshift Mutations.

  PMID 35044202 · PMC8768832 · Microbiology spectrum · 2022 · 8 claims · 7 setups

  Has reproduction · 79

  AgrVATE, a novel kmer-based BLASTn and in silico PCR/Snippy pipeline, enables fast, standardized agr group typing and frameshift/null mutation detection from genome assemblies

  aureus complete extracted agr kmer-based sheep mash

• CIRCprimerXL: Convenient and High-Throughput PCR Primer Design for Circular RNA Quantification.

  PMID 36304334 · PMC9580850 · Frontiers in bioinformatics · 2022 · 8 claims · 5 setups

  Has reproduction · 88

  CIRCprimerXL is a high-throughput, user-friendly circRNA RT-qPCR primer design pipeline available as both a web tool and a standalone Nextflow/Docker pipeline

  synthetic sw480 circrnas rt-qpcr circrna primer

• p53 mutations, protein expression and cell proliferation in squamous cell carcinomas of the head and neck.

  PMID 7710950 · PMC2033757 · British journal of cancer · 1995 · 6 claims · 4 setups

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  There is a discrepancy between p53 immunoreactivity and p53 gene mutation status, with mutations found in similar proportions of immunopositive and immunonegative tumours.

  formalin-fixed extracted p53-immunonegative scchn immunohistochemistry pcr-single sequencing

• Mutational analyses of multiple target genes in histologically heterogeneous gastric cancer with microsatellite instability.

  PMID 10081489 · PMC5921733 · Japanese journal of cancer research : Gann · 1998 · 7 claims · 5 setups

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  MSI frequency in gastric cancers with histological heterogeneity was 35% (7/20 cases) and 28% (11/40 tumor DNAs), consistent with prior gastric cancer MSI studies.

  formalin-fixed msi-positive surgically microsatellite pcr-sscp histopathological

• Multiple K-ras mutations in hyperplasia and carcinoma in cases of human pancreatic carcinoma.

  PMID 10543256 · PMC5926143 · Japanese journal of cancer research : Gann · 1999 · 7 claims · 6 setups

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  K-ras codon 12 mutations are present in the majority of solid-type (85%) and ductectatic-type (73%) pancreatic carcinomas.

  pancreatic mucous microdissected extracted k-ras histopathological microdissection

• Microsatellite instability and mismatch repair gene inactivation in sporadic pancreatic and colon tumours.

  PMID 10389971 · PMC2363009 · British journal of cancer · 1999 · 6 claims · 5 setups

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  Microsatellite instability is common in sporadic pancreatic cancer but occurs at a uniformly low rate and is not accompanied by hMLH1/hMSH2 alterations, suggesting it does not drive pancreatic tumorigenesis.

  sporadic msi-positive tumour unstable microsatellite denaturing sequencing

• Mutation analysis of the Fanconi anaemia A gene in breast tumours with loss of heterozygosity at 16q24.3.

  PMID 10098735 · PMC2362253 · British journal of cancer · 1999 · 7 claims · 6 setups

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  The FAA gene is not the gene targeted by LOH at 16q24.3 in breast cancer

  breast tumour sscp exon-by-exon southern

• Genomic structure and alterations of homeobox gene CDX2 in colorectal carcinomas.

  PMID 10027310 · PMC2362430 · British journal of cancer · 1999 · 8 claims · 6 setups

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  CDX2 expression is decreased in colorectal carcinomas in prior studies

  genomic sporadic hnpcc carcinoma standard pcr-sscp cloning