Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

Publications 1.3k Datasets 392.5k Experiments 215

System / cell line: populations ✕ Clear

Nucleotide sequence analyses of the MRP1 gene in four populations suggest negative selection on its coding region.

PMID 16684361 · PMC1488846 · BMC genomics · 2006 · 8 claims · 5 setups

Full-text index only

The coding region of MRP1 shows evidence of negative selection or recent population expansion based on nucleotide diversity statistics

healthy mrp1 population novo population functional
TEMP: a computational method for analyzing transposable element polymorphism in populations.

PMID 24753423 · PMC4066757 · Nucleic acids research · 2014 · 8 claims · 8 setups

Has reproduction · 61

TEMP combines pair-end (discordant) read and split (soft-clipped) read information to identify both presence and absence of TE insertions in genomic DNA from heterogeneous/pooled samples.

drosophila five four melanogaster simulated comparative whole-genome
GABRG1 and GABRA2 as independent predictors for alcoholism in two populations.

PMID 18818659 · PMC2656604 · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2009 · 8 claims · 8 setups

Full-text index only

GABRG1 SNPs and haplotypes are significantly associated with alcohol use disorder (AUD) in both Finnish Caucasians and Plains American Indians

finnish plains population hapmap snp haplotype ancestry
Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study.

PMID 18539534 · PMC2832754 · The Lancet. Neurology · 2008 · 8 claims · 7 setups

Full-text index only

LRRK2-associated PD can be distinguished from idiopathic PD by a more benign motor and non-motor phenotype

unrelated patients people homozygous genetic standardized olfaction
Genomic medicine and developing countries: creating a room of their own.

PMID 18487990 · PMC7096950 · Nature reviews. Genetics · 2008 · 8 claims · 6 setups

Full-text index only

Developing countries can harness human genetic variation to benefit their populations and economies rather than only importing technology from developed nations.

key polio asthma patients in-depth viral genetic
Iterative pruning PCA improves resolution of highly structured populations.

PMID 19930644 · PMC2790469 · BMC bioinformatics · 2009 · 7 claims · 7 setups

Full-text index only

ipPCA is a novel algorithm that assigns individuals to subpopulations and infers the total number of subpopulations (K) present in genotypic data

simulated hapmap cattle shriver's simulated snp comparative
Bacterial chromatin remodeling associated with transcription-induced domains at pathogenicity Islands.

PMID 41507177 · PMC12783615 · Nature communications · 2026 · 8 claims · 8 setups

Full-text index only

Silent SPIs display spurious antisense transcription originating from H-NS-free regions

salmonella facs hi-c chip
Addressing the age-old question of old age.

PMID 15287970 · PMC507873 · Genome biology · 2004 · 8 claims · 6 setups

Full-text index only

Dietary restriction and reduced temperature extend Drosophila lifespan via intrinsically different demographic mechanisms: dietary restriction lowers intrinsic frailty, while lower temperature reduces the rate of senescence.

drosophila populations australian centenarians demographic historical peptide
Candidates for Balancing Selection in Leishmania donovani Complex Parasites.

PMID 34865011 · PMC8717319 · Genome biology and evolution · 2021 · 7 claims · 8 setups

Has reproduction · 64

Five genetically distinct, well-sampled populations exist within the L. donovani complex: EA1, EA2 (East Africa), ISC1, ISC2 (Indian subcontinent), and BM (Brazil-Mediterranean)

infantum donovani snp populations whole-genome read admixture
Assessing personalized molecular portraits underlying endothelial-to-mesenchymal transition within pulmonary arterial hypertension.

PMID 39462326 · PMC11513636 · Molecular medicine (Cambridge, Mass.) · 2024 · 8 claims · 8 setups

Has reproduction · 81

scRNA-seq of PAH and control lung tissue identifies nine distinct cell populations with high heterogeneity in composition, function, distribution, and communication

lung pah scrna-seq-derived endothelial scrna-seq bulk cell-cell
Discovery and characterization of Alu repeat sequences via precise local read assembly.

PMID 26503250 · PMC4666360 · Nucleic acids research · 2015 · 7 claims · 8 setups

Has reproduction · 69

Combining Alu-supporting read detection (RetroSeq) with local de novo assembly (CAP3) reconstructs the full sequence of non-reference Alu insertions from Illumina paired-end WGS reads

hgdp insertion-supporting candidate assembled genome discordant novo
Global variation in copy number in the human genome.

PMID 17122850 · PMC2669898 · Nature · 2006 · 8 claims · 6 setups

Full-text index only

A first-generation CNV map of the human genome was constructed from 270 HapMap individuals across four populations, identifying 1,447 CNV regions covering ~360 Mb (12%) of the genome.

hapmap subset blood snp array karyotyping
Sequence variation and linkage disequilibrium in the GABA transporter-1 gene (SLC6A1) in five populations: implications for pharmacogenetic research.

PMID 17941974 · PMC2175509 · BMC genetics · 2007 · 8 claims · 7 setups

Full-text index only

SLC6A1 shows low levels of LD and an absence of major LD blocks across all five populations studied

african-american thai same study sanger snp genotyping
Inter-population variability of DEFA3 gene absence: correlation with haplotype structure and population variability.

PMID 17214878 · PMC1779775 · BMC genomics · 2007 · 8 claims · 7 setups

Full-text index only

The proportion of subjects lacking DEFA3 varies significantly by population, from 10% to 37%

genomic hapmap 150-kb alpha-defensin pcr-rflp snp linkage
Obesity genes: so close and yet so far..

PMID 19046411 · PMC2776388 · Journal of biology · 2008 · 8 claims · 7 setups

Full-text index only

GWA studies have confirmed only a few obesity-associated loci (INSIG2, FTO, MC4R) so far, each with modest individual effects on BMI

population drosophila founder genome-wide candidate-region candidate
SPSmart: adapting population based SNP genotype databases for fast and comprehensive web access.

PMID 18847484 · PMC2576268 · BMC bioinformatics · 2008 · 7 claims · 8 setups

Full-text index only

SPSmart is a novel tool for accessing and combining large-scale SNP genotype databases with population information

hapmap perlegen stanford michigan snp cross-database chromosome
Worldwide distribution of NAT2 diversity: implications for NAT2 evolutionary history.

PMID 18304320 · PMC2292740 · BMC genetics · 2008 · 8 claims · 8 setups

Full-text index only

NAT2 coding region sequence variation in the Mandenka and other sub-Saharan African populations is consistent with selective neutrality and constant population size.

mandenka worldwide hapmap nat2 full snp analysis
The Genetic and Morphological Basis of Local Adaptation to Elevational Extremes in an Alpine Finch.

PMID 41624103 · PMC12853319 · Ecology and evolution · 2026 · 8 claims · 6 setups

Full-text index only

Birds in the warmer Piute Pass population were predicted to have longer wings and larger beaks per Allen's rule

sierra body blood same morphometric feather whole-genome
Easy and efficient ensemble gene set testing with EGSEA.

PMID 29333246 · PMC5747338 · F1000Research · 2017 · 8 claims · 2 setups

Has reproduction · 97

EGSEA combines results from up to 12 prominent gene set testing algorithms to obtain a consensus ranking of biologically relevant gene sets

mammary bulk microarray
Population Genomic Analyses Suggest a Hybrid Origin, Cryptic Sexuality, and Decay of Genes Regulating Seed Development for the Putatively Strictly Asexual Kingdonia uniflora (Circaeasteraceae, Ranunculales).

PMID 36674965 · PMC9866071 · International journal of molecular sciences · 2023 · 8 claims · 8 setups

Has reproduction · 51

K. uniflora shows high allelic heterozygosity (negative F_IS) consistent with theoretical expectations under asexual evolution

uniflora whole-genome phylogenomic population

Experiments

Nucleotide sequence analyses of the MRP1 gene in four populations suggest negative selection on its coding region.

TEMP: a computational method for analyzing transposable element polymorphism in populations.

GABRG1 and GABRA2 as independent predictors for alcoholism in two populations.

Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study.

Genomic medicine and developing countries: creating a room of their own.

Iterative pruning PCA improves resolution of highly structured populations.

Bacterial chromatin remodeling associated with transcription-induced domains at pathogenicity Islands.

Addressing the age-old question of old age.

Candidates for Balancing Selection in Leishmania donovani Complex Parasites.

Assessing personalized molecular portraits underlying endothelial-to-mesenchymal transition within pulmonary arterial hypertension.

Discovery and characterization of Alu repeat sequences via precise local read assembly.

Global variation in copy number in the human genome.

Sequence variation and linkage disequilibrium in the GABA transporter-1 gene (SLC6A1) in five populations: implications for pharmacogenetic research.

Inter-population variability of DEFA3 gene absence: correlation with haplotype structure and population variability.

Obesity genes: so close and yet so far..

SPSmart: adapting population based SNP genotype databases for fast and comprehensive web access.

Worldwide distribution of NAT2 diversity: implications for NAT2 evolutionary history.

The Genetic and Morphological Basis of Local Adaptation to Elevational Extremes in an Alpine Finch.

Easy and efficient ensemble gene set testing with EGSEA.

Population Genomic Analyses Suggest a Hybrid Origin, Cryptic Sexuality, and Decay of Genes Regulating Seed Development for the Putatively Strictly Asexual Kingdonia uniflora (Circaeasteraceae, Ranunculales).