Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Single-nucleus multiome analysis in the human prefrontal cortex identifies gene expression and cis-regulatory elements associated with aging.

  PMID 41832957 · PMC13137218 · Cell reports · 2026 · 8 claims · 8 setups

  Full-text index only

  Generated a single-nucleus multiome (snATAC + gene expression) dataset from 357 human dorsolateral prefrontal cortex samples (ages 15-100, European and African admixed ancestry), yielding over 1.5 million cells as a public resource.

  postmortem million+ pfc each single-nucleus umap pseudobulk

• Pathway-specific canalization and plasticity of gene expression during C. elegans dauer development.

  PMID 41890963 · PMC13014971 · iScience · 2026 · 8 claims · 7 setups

  Full-text index only

  Dauers induced by different environmental (starvation, pheromone, heat) or genetic (daf-2, daf-7, ilc-17.1, cep-1 OE) stimuli are transcriptionally distinct from each other and from continuously developing WT L2/L3 and adults

  elegans bulk principal likelihood

• PeakPrime: a peak-guided primer design pipeline for target enrichment in 3'-end RNA-seq.

  PMID 41919010 · PMC13034549 · Bioinformatics advances · 2026 · 8 claims · 7 setups

  Full-text index only

  PeakPrime is a reproducible Nextflow pipeline that calls 3′ RNA-seq coverage peaks (MACS2), selects exonic windows, designs strand-appropriate primers (Primer3), and screens specificity (Bowtie2)

  imr-32 universal candidate 10m-read rna-seq targeted quantitative

• Loss of long-range co-expression is a common feature in cancer.

  PMID 41935098 · PMC13247121 · NPJ systems biology and applications · 2026 · 8 claims · 7 setups

  Full-text index only

  In cancer, the strongest co-expressed gene pairs (top MI values) are predominantly intra-chromosomal, unlike in normal tissue.

  tissues same bladder cancer bulk differential bootstrap

• Human endogenous retrovirus profiling reveals heterogenous expression in cutaneous melanoma.

  PMID 41971443 · PMC13061668 · Frontiers in oncology · 2026 · 7 claims · 8 setups

  Full-text index only

  HERV expression differs between primary and metastatic cutaneous melanoma

  tcga-skcm metastatic normal selected bulk consensus orf

• SnakeAltPromoter Facilitates Differential Alternative Promoter Analysis.

  PMID 41993886 · PMC13082578 · Computational and structural biotechnology journal · 2026 · 6 claims · 6 setups

  Full-text index only

  SnakeAltPromoter is the first unified, reproducible Snakemake workflow that automates alternative promoter analysis from raw RNA-seq data using 3 complementary methods (ProActiv, Salmon, DEXSeq)

  heart brain gm12878 simulated bulk cage rna-seq

• Deciphering immune and cellular reprogramming during the progression from inflammatory bowel disease to colorectal cancer using multi-omics single-cell and spatial transcriptomics.

  PMID 42001187 · PMC13122952 · Journal of translational medicine · 2026 · 8 claims · 5 setups

  Full-text index only

  CEACAM5 is consistently upregulated across Crohn's disease and ulcerative colitis samples and links epithelial activation in IBD to tumorigenic processes in CRC

  intestinal colorectal single-cell serum bulk single-cell spatial

• DNA methylation profiles at hospital admission are associated with subsequent severe COVID-19 outcomes.

  PMID 42021404 · PMC13251264 · Clinical epigenetics · 2026 · 7 claims · 5 setups

  Full-text index only

  DNA methylation profiles at hospital admission differ among disease trajectory groups (TGs) and are associated with subsequent disease progression.

  pbmcs blood immune end-stage targeted rna-seq mass

• Gene Expression Patterns Regulating Peanut Reproductive Phenology.

  PMID 42099581 · PMC13147162 · Plant direct · 2026 · 8 claims · 6 setups

  Full-text index only

  Overall gene expression was distinct between Tifrunner and GT-C20 in both leaf and shoot tip tissues

  leaf deseq2 shoot gene bulk differential principal

• Determining the quality and complexity of next-generation sequencing data without a reference genome.

  PMID 25514851 · PMC4298064 · Genome biology · 2014 · 8 claims · 8 setups

  Has reproduction · 78

  kPAL, an open-source alignment-free package, assesses sequencing data quality and complexity using k-mer frequency profiles and pairwise distances between them, without a reference sequence.

  rna-seq genome wgs exome k-mer rna-seq read

• Transcriptional landscape of repetitive elements in normal and cancer human cells.

  PMID 25012247 · PMC4122776 · BMC genomics · 2014 · 8 claims · 8 setups

  Has reproduction · 76

  RepEnrich, a computational method that uses all mapping reads (uniquely mapping plus multi-mapping reads assigned to repetitive element subfamily assemblies/pseudogenomes), quantifies genome-wide repetitive element enrichment

  chromosomes lines imr-90 prostate simulated pol chip-seq

• MicroRNA Enrichment and Docking-Based Evaluation of Ilomastat Targeting of MMP-2 in Esophageal Squamous Cell Carcinoma: Insights from a South African Cohort.

  PMID 42158110 · PMC13181172 · Computational and structural biotechnology journal · 2026 · 7 claims · 5 setups

  Full-text index only

  The miR-29 family inhibits MMP-2 and represents a key regulatory axis in tumor invasion

  paired deg mmp-2 escc bulk pathway molecular

• Detecting unannotated splicing events in short-read RNA-seq with SAMI, a UMI-aware Nextflow pipeline.

  PMID 42166739 · PMC13242923 · Bioinformatics (Oxford, England) · 2026 · 8 claims · 5 setups

  Full-text index only

  SAMI is a UMI-aware, Singularity-contained Nextflow pipeline that detects splicing events diverging from transcript annotations directly from raw FASTQ files.

  seraseq simulated small processed targeted simulated computation

• Integrative sRNA, DNA Methylation, and Transcriptomics Reveals Dynamic Epigenetic Reprogramming of Meloidogyne javanica-Induced Galls in Arabidopsis.

  PMID 42196344 · PMC13207400 · International journal of molecular sciences · 2026 · 8 claims · 5 setups

  Full-text index only

  Enrichment of 24 nt sRNAs (rasiRNAs) is a conserved hallmark of galls across early and late infection stages

  meloidogyne arabidopsis javanica-induced small rasirna chromosomal

• Mouse placentae generated by in vitro fertilization exhibit altered gene expression, activated hypoxia responses, and reduced fitness†.

  PMID 40874534 · PMC12808545 · Biology of reproduction · 2026 · 6 claims · 6 setups

  Full-text index only

  IVF-conceived mouse placentae exhibit global and cell type–specific gene expression differences compared to FB placentae

  e12.5 differentially trophoblast placenta single-nucleus pseudobulk pathway

• Integrated transcriptomic landscape of medulloblastoma and ependymoma reveals novel tumor subtype-specific biology.

  PMID 41159380 · PMC12979040 · Neuro-oncology · 2026 · 8 claims · 8 setups

  Full-text index only

  A unified UMAP-based transcriptomic landscape built from 888 medulloblastoma and 370 ependymoma tumors reveals distinct clusters corresponding to known and novel molecular subtypes.

  medulloblastoma ependymoma healthy shh bulk fusion copy

• ATACdb 2.0: a comprehensive chromatin accessibility database of human and mouse.

  PMID 41243977 · PMC12807738 · Nucleic acids research · 2026 · 8 claims · 8 setups

  Full-text index only

  ATACdb 2.0 expands data scale, adding mouse chromatin accessibility data and substantially expanding human samples, plus pseudo-bulk ATAC-seq profiles built from scATAC-seq data to increase cell type diversity

  geo scatac-ref bulk scatac-seq h3k27ac

• Estrogen Production in Pancreatic Cancer Shapes a Tumor-Suppressive Stromal Microenvironment.

  PMID 41258799 · PMC12862343 · Cancer research · 2026 · 8 claims · 6 setups

  Full-text index only

  Serum levels of stromal biomarkers associated with favorable outcomes were significantly higher in female patients with PDAC than in male patients

  pdac pdx magnetic bioinformatic single-nucleus

• FracFixR: a compositional statistical framework for absolute proportion estimation between fractions in RNA sequencing data.

  PMID 41264734 · PMC12866640 · Bioinformatics (Oxford, England) · 2026 · 7 claims · 5 setups

  Full-text index only

  FracFixR reconstructs original fraction proportions by modeling the compositional relationship between whole and fractionated RNA samples using non-negative least squares (NNLS) regression on selected transcripts

  gm12878 mixtures reh long-read polysome synthetic

• B-lineage commitment is dependent on a reversible epigenetic switch.

  PMID 41266087 · PMC12863259 · Genes & development · 2026 · 8 claims · 8 setups

  Full-text index only

  B-lymphoid commitment is mediated by a transcription factor-dose-dependent epigenetic switch that suppresses inherent T-lineage potential in early lymphoid progenitors

  bone expanded pax5 ebf1 combined atac-seq chip-seq