Experiments
Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).
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Functional human salivary gland organoids for tissue regeneration in chemically defined culture systems.
PMID 41707649 · PMC12923968 · Cell reports. Medicine · 2026 · 8 claims · 8 setups
A chemically defined, Matrigel-free complete medium (CM) generates hSGOs with more cohesive spheroid morphology, organized epithelial layers, and improved apical polarization compared to keratinocyte medium (KM-S) or Matrigel-embedded conditions
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CITED2 is a druggable epigenetic switch coupling neuronal maturation to regenerative decline.
PMID 41731079 · PMC13083982 · EMBO molecular medicine · 2026 · 8 claims · 8 setups
The transition from immature non-polarized to mature polarized DRG neurons (E12.5-E17.5) is associated with loss of gene expression signatures needed for regenerative growth competence.
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Role of CTGF-LRP1 in impaired healing of cesarean section incisions.
PMID 41764198 · PMC13066582 · Nature communications · 2026 · 8 claims · 8 setups
A specific fibroblast subgroup (FB3) in niche tissue shows LRP1 deficiency associated with reduced extracellular matrix (ECM) synthesis capacity
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Identification and validation of prognostic genes related to glycolysis and M2 macrophage in hepatocellular carcinoma: an integrated analysis of bulk RNA sequencing and single-cell RNA sequencing.
PMID 41766871 · PMC12935947 · Frontiers in immunology · 2026 · 8 claims · 8 setups
52 candidate genes were identified at the intersection of glycolysis-related genes (GRGs), M2 macrophage-related genes (MRGs), and HCC-vs-control DEGs (DEGs2).
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Has reproduction · 68
Endogenous retroviral elements LTR8B and MER65 rewire PSG9 regulation to control trophoblast syncytialization and pre-eclampsia risk.
PMID 41796334 · PMC12969887 · Genome biology · 2026 · 8 claims · 8 setups
LTR8B is a placentally-relevant cis-regulatory element (CRE), notably within the PSG array
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Has reproduction · 85
The exonuclease Xrn1 activates transcription and translation of mRNAs encoding membrane proteins.
PMID 30899024 · PMC6428865 · Nature communications · 2019 · 8 claims · 8 setups
Xrn1 promotes translation of a specific group of transcripts encoding membrane proteins
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Has reproduction · 50
Yap1 safeguards mouse embryonic stem cells from excessive apoptosis during differentiation.
PMID 30561326 · PMC6307859 · eLife · 2018 · 7 claims · 8 setups
Yap1 knockout (KO) ESCs undergo massive, caspase-dependent cell death upon exiting self-renewal (LIF withdrawal), while self-renewing KO cells are unaffected.
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Has reproduction · 55
Identification and verification of diagnostic biomarkers in recurrent pregnancy loss via machine learning algorithm and WGCNA.
PMID 37691920 · PMC10485775 · Frontiers in immunology · 2023 · 8 claims · 8 setups
352 DEGs (198 up-regulated, 154 down-regulated) were identified between RPL and control endometrial samples
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Has reproduction · 89
Depletion of HIV reservoir by activation of ISR signaling in resting CD4(+)T cells.
PMID 36590168 · PMC9800255 · iScience · 2023 · 8 claims · 8 setups
Activation of ISR/ATF4 signaling (via HA15) reverses HIV latency in Jurkat models of HIV latency (J-Lat A1, 2D10)
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Has reproduction · 86
Screening of core genes prognostic for sepsis and construction of a ceRNA regulatory network.
PMID 36855106 · PMC9976425 · BMC medical genomics · 2023 · 8 claims · 7 setups
RNA-seq of peripheral blood from 23 sepsis patients and 10 healthy controls identifies 1,044 DEmRNAs, 66 DEmiRNAs and 155 DElncRNAs.
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Has reproduction
Comprehensive analysis of m(6)A methylome alterations after azacytidine plus venetoclax treatment for acute myeloid leukemia by nanopore sequencing.
PMID 38510975 · PMC10950754 · Computational and structural biotechnology journal · 2024 · 8 claims · 6 setups
m6A site number and m6A levels are significantly lower in post-treatment complete remission (CR) bone marrow than in pre-treatment AML bone marrow
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Has reproduction · 71
Developing a novel immune infiltration-associated mitophagy prediction model for amyotrophic lateral sclerosis using bioinformatics strategies.
PMID 38601155 · PMC11005030 · Frontiers in immunology · 2024 · 8 claims · 8 setups
Mitophagy-related genes associated with immune infiltration have diagnostic/prognostic significance in ALS
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Has reproduction · 83
Discovery and validation of molecular patterns and immune characteristics in the peripheral blood of ischemic stroke patients.
PMID 38650649 · PMC11034498 · PeerJ · 2024 · 8 claims · 8 setups
188 differentially expressed genes (DEGs) between IS and control blood samples were identified and enriched in immune-related biological pathways
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Has reproduction · 81
Deubiquitination enzyme USP35 negatively regulates MAVS signaling to inhibit anti-tumor immunity.
PMID 40016186 · PMC11868397 · Cell death & disease · 2025 · 8 claims · 8 setups
USP35 interacts with MAVS and removes its K63-linked polyubiquitin chains, inhibiting viral-induced MAVS-TBK1-IRF3 activation and downstream inflammatory gene expression
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Has reproduction · 51
A platelet-related signature for predicting the prognosis and immunotherapy benefit in bladder cancer based on machine learning combinations.
PMID 39280688 · PMC11399026 · Translational andrology and urology · 2024 · 8 claims · 8 setups
An Enet (alpha=0.4) machine-learning algorithm built from 10 platelet-related genes yields the optimal platelet-related signature (PRS) for bladder cancer prognosis, with average C-index 0.73
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Has reproduction · 93
Integrated bioinformatics analysis screened the key genes and pathways of idiopathic pulmonary fibrosis.
PMID 40280949 · PMC12032202 · Scientific reports · 2025 · 8 claims · 8 setups
5328 differentially expressed transcripts (4083 genes) were identified in GSE173355 by limma, with 4012 transcripts (3206 genes) confirmed by both limma and edgeR (logFC>1, FDR<0.05)
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Has reproduction · 80
Comprehensive analysis of transcriptomics and radiomics revealed the potential of TEDC2 as a diagnostic marker for lung adenocarcinoma.
PMID 39553728 · PMC11569783 · PeerJ · 2024 · 8 claims · 8 setups
WGCNA identified 214 key genes in the blue module most correlated with LUAD
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Has reproduction · 49
Integrative transcriptomics and single-cell transcriptomics analyses reveal potential biomarkers and mechanisms of action in papillary thyroid carcinoma.
PMID 40520228 · PMC12162626 · Frontiers in genetics · 2025 · 8 claims · 8 setups
ENTPD1, SERPINA1, and TACSTD2 are potential transcriptomic biomarkers for PTC
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Has reproduction · 64
Integrated multi-omics analysis combined with clinical validation reveals that HLA-DRB5 and ODAPH are causal risk genes for keratoconus.
PMID 41803193 · PMC13179358 · Scientific reports · 2026 · 8 claims · 8 setups
2,884 differentially expressed genes (DEGs) were identified as the union of upregulated genes from two independent KC transcriptome datasets (GSE151631, GSE77938), enriched in cell adhesion, immune response, and TNF/IL-17 signaling pathways.
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Has reproduction · 31
Gene Regulatory Interactions at Lamina-Associated Domains.
PMID 36833261 · PMC9957430 · Genes · 2023 · 8 claims · 8 setups
Active genes in constitutive LADs (cLADs) reside in euchromatic regions with low LMNB1 and LMNA/C enrichment, i.e., are locally detached from the nuclear lamina