Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

Publications 1.3k Datasets 392.5k Experiments 558

System / cell line: clinical ✕ Clear

Targeting Wnt/β-catenin and circadian regulator restores PRC2/EZH2-controlled chromatin bivalency and suppresses cell state diversity.

PMID 41842971 · PMC13132380 · The Journal of clinical investigation · 2026 · 8 claims · 8 setups

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PRC2i/EZH2i alone or combined with AR inhibitors induce diverse cell state programs (CSPs) that increase tumor cell invasion, metastasis, and drug resistance despite only modest suppression of tumor growth.

lncap pca pdx clinical viability tumor ic50
Spatial and temporal description of antimalarial drug resistance markers in Ghana using targeted amplicon deep sequencing.

PMID 42118117 · PMC13231922 · Antimicrobial agents and chemotherapy · 2026 · 7 claims · 1 setups

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Zonal differences in pfmdr1 N86-F184-S1034-N1042-D1246 (NFSND) haplotype trends are likely due to lower amodiaquine drug pressure in the Coastal zone compared to Forest and Savannah.

plasmodium targeted
Failure to detect mutations in the retinoblastoma protein-binding domain of the transcription factor E2F-1 in human cancers.

PMID 9045954 · PMC5921028 · Japanese journal of cancer research : Gann · 1996 · 4 claims · 6 setups

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E2F-1 function is regulated by the RB protein through E2F-1's RB-binding domain, positioning E2F-1 downstream of RB

lung pancreatic stomach colon pcr-sscp
Meta-analysis of six dairy cattle breeds reveals biologically relevant candidate genes for mastitis resistance.

PMID 39009986 · PMC11247842 · Genetics, selection, evolution : GSE · 2024 · 5 claims · 8 setups

Has reproduction · 69

Meta-analysis of GWAS across six dairy cattle breeds identifies 58 lead markers associated with clinical mastitis and somatic cell score

six combined per-breed genome-wide sequence-based trans-ethnic fixed-effect
Phenotypic characteristics of colo-rectal cancer in I1307K APC germline mutation carriers compared with sporadic cases.

PMID 11720476 · PMC2375261 · British journal of cancer · 2001 · 8 claims · 5 setups

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I1307K APC germline mutation carriers were identified in 28 of 307 (9.1%) unselected Israeli CRC patients

genomic pcr unselected i1307k mutation sequencing clinical
Clinico-pathogenetic findings and management of chondrodystrophic myotonia (Schwartz-Jampel syndrome): a case report.

PMID 12839625 · PMC166146 · BMC neurology · 2003 · 8 claims · 7 setups

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The patient is a compound heterozygote with a different splicing mutation in each Perlecan allele, causing a significant reduction in production of the normal (wild-type) protein.

8-year-old muscle lower skeletal molecular immunostaining electromyogram
Codon usage comparison of novel genes in clinical isolates of Haemophilus influenzae.

PMID 15983137 · PMC1160521 · Nucleic acids research · 2005 · 8 claims · 4 setups

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A codon usage similarity statistic (ε, based on squared/absolute differences of codon frequencies with an optimized amino acid usage factor) was developed to compare ORFs against a set of 80 reference genomes.

influenzae novel reference codon phylogenetic comparative
Genomic sequencing of the severe acute respiratory syndrome-coronavirus.

PMID 16916263 · PMC7121524 · Methods in molecular biology (Clifton, N.J.) · 2006 · 7 claims · 7 setups

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PCR-based amplification and direct sequencing of SARS-CoV genome fragments is feasible from uncultured clinical specimens (serum, nasopharyngeal aspirate, stool), avoiding culture-derived artifacts and biohazard risk.

sars-cov extracted cdna pcr viral reverse real-time
Association of Escherichia coli O157:H7 tir polymorphisms with human infection.

PMID 17718910 · PMC2063500 · BMC infectious diseases · 2007 · 8 claims · 6 setups

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tir polymorphisms 255 T>A and RR1-RU3 (presence/absence) associate strongly with human vs bovine isolate source

stec pcr multiplex elisa
Genome-wide diversity and selective pressure in the human rhinovirus.

PMID 17477878 · PMC1892812 · Virology journal · 2007 · 7 claims · 6 setups

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Whole genome and subgenomic phylogenies of HRV are essentially identical at every locus, indicating consistent phylogenetic patterns across the genome.

diverse hrv fully hrva genome phylogenetic pairwise
Lineage specific recombination rates and microevolution in Listeria monocytogenes.

PMID 18842152 · PMC2576243 · BMC evolutionary biology · 2008 · 8 claims · 6 setups

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Recombination is more prevalent in lineage II than in lineage I

listeria allelic unique monocytogenes multilocus sawyer's genealogical
A single-step sequencing method for the identification of Mycobacterium tuberculosis complex species.

PMID 18618024 · PMC2453075 · PLoS neglected tropical diseases · 2008 · 7 claims · 8 setups

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ETR-D sequencing allows accurate, single-step identification of MTC species, circumventing the expensive polyphasic approach.

mtc tuberculosis phenotypic pcr mptr
Identification of novel markers for liver fibrosis in HIV/hepatitis C virus coinfected individuals using genomics-based approach.

PMID 18614866 · PMC2654216 · AIDS (London, England) · 2008 · 8 claims · 6 setups

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An 8-marker model combining six serum markers, age, and ART experience predicts liver fibrosis stage with an AUROC of 0.904.

pbmcs liver serum blood microarray liver serum
Integration of bioinformatic tools for the detection of SARS-CoV-2 co-infection cases.

PMID 41609640 · PMC12856159 · Microbial genomics · 2026 · 8 claims · 8 setups

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Sample PH-RITM-1395 represents a Delta–Omicron co-infection, confirmed by convergent evidence from Nextclade, bammix, Freyja, VirStrain, AAF analysis and amplicon sorting rather than contamination

consensus aligned raw bam nextclade nucleotide strain-level
The complement system contributes to the immunosuppressive microenvironment of uveal melanoma.

PMID 41803879 · PMC13130498 · Journal of translational medicine · 2026 · 8 claims · 8 setups

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Primary UM (pUM) preferentially expresses early complement pathway components over terminal membrane attack complex elements, with early factors showing prognostic significance.

short-term metastatic normal pum bulk label-free single-cell
Integrating multi-omics data reveals the antitumor role and clinical benefits of gamma-delta T cells in triple-negative breast cancer.

PMID 40197136 · PMC11974128 · BMC cancer · 2025 · 8 claims · 8 setups

Has reproduction · 59

High γδT cell infiltration is associated with favorable prognosis in TNBC but not in HR-positive or HER2-positive breast cancer

tnbc tcga-brca metabric single-cell bulk immunohistochemistry
The Genomic Aftermath of Hybridization in the Opportunistic Pathogen Candida metapsilosis.

PMID 26517373 · PMC4627764 · PLoS genetics · 2015 · 8 claims · 6 setups

Has reproduction · 56

C. metapsilosis is a highly heterozygous hybrid species formed from a single past hybridization event between two parental lineages ~4.5% divergent in sequence.

metapsilosis whole-genome novo pulsed
The COMBAT-TB Workbench: Making Powerful Mycobacterium tuberculosis Bioinformatics Accessible.

PMID 35138128 · PMC8827006 · mSphere · 2022 · 8 claims · 5 setups

Has reproduction · 90

The COMBAT-TB Workbench combines the IRIDA web platform and the Galaxy workflow platform into a single easy-to-install, Docker-based application

tuberculosis outlier whole-genome maximum-likelihood read
Machine learning developed an intratumor heterogeneity signature for predicting clinical outcome and immunotherapy benefit in bladder cancer.

PMID 39100839 · PMC11291408 · Translational andrology and urology · 2024 · 8 claims · 8 setups

Has reproduction · 40

An integrative machine learning procedure (10 methods, 101 algorithm combinations) identified an Enet (alpha=0.2)-based intratumor heterogeneity-related signature (IRS) with the highest average C-index (0.69) across TCGA and GEO cohorts

bladder skin bulk integrative immune
rpoB Gene mutations in rifampin-resistant Mycobacterium tuberculosis identified by polymerase chain reaction single-stranded conformational polymorphism.

PMID 11747730 · PMC2631921 · Emerging infectious diseases · 2001 · 6 claims · 4 setups

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PCR-SSCP has high specificity (100%) but poor sensitivity (31.4%) for detecting rpoB mutations in rifampin-resistant M. tuberculosis clinical isolates

tuberculosis same chromosomal pcr-sscp sequencing mic

Experiments

Targeting Wnt/β-catenin and circadian regulator restores PRC2/EZH2-controlled chromatin bivalency and suppresses cell state diversity.

Spatial and temporal description of antimalarial drug resistance markers in Ghana using targeted amplicon deep sequencing.

Failure to detect mutations in the retinoblastoma protein-binding domain of the transcription factor E2F-1 in human cancers.

Meta-analysis of six dairy cattle breeds reveals biologically relevant candidate genes for mastitis resistance.

Phenotypic characteristics of colo-rectal cancer in I1307K APC germline mutation carriers compared with sporadic cases.

Clinico-pathogenetic findings and management of chondrodystrophic myotonia (Schwartz-Jampel syndrome): a case report.

Codon usage comparison of novel genes in clinical isolates of Haemophilus influenzae.

Genomic sequencing of the severe acute respiratory syndrome-coronavirus.

Association of Escherichia coli O157:H7 tir polymorphisms with human infection.

Genome-wide diversity and selective pressure in the human rhinovirus.

Lineage specific recombination rates and microevolution in Listeria monocytogenes.

A single-step sequencing method for the identification of Mycobacterium tuberculosis complex species.

Identification of novel markers for liver fibrosis in HIV/hepatitis C virus coinfected individuals using genomics-based approach.

Integration of bioinformatic tools for the detection of SARS-CoV-2 co-infection cases.

The complement system contributes to the immunosuppressive microenvironment of uveal melanoma.

Integrating multi-omics data reveals the antitumor role and clinical benefits of gamma-delta T cells in triple-negative breast cancer.

The Genomic Aftermath of Hybridization in the Opportunistic Pathogen Candida metapsilosis.

The COMBAT-TB Workbench: Making Powerful Mycobacterium tuberculosis Bioinformatics Accessible.

Machine learning developed an intratumor heterogeneity signature for predicting clinical outcome and immunotherapy benefit in bladder cancer.

rpoB Gene mutations in rifampin-resistant Mycobacterium tuberculosis identified by polymerase chain reaction single-stranded conformational polymorphism.