Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Empowering integrative and collaborative exploration of single-cell and spatial multimodal data with SGS genome browser.

  PMID 40233745 · PMC12143324 · Cell genomics · 2025 · 8 claims · 6 setups

  Has reproduction

  SGS is a user-friendly, collaborative, versatile browser for integrative visualization of single-cell and spatial multimodal (scMulti-omics) data

  dorsal hematopoietic brain onek1k sn-m3c-seq scatac-seq spatial

• Distal enhancers regulate mammalian early embryonic lineage differentiation through long-range interactions.

  PMID 41562256 · PMC12820533 · Nucleic acids research · 2026 · 8 claims · 8 setups

  Full-text index only

  Lineage-specific H3K27ac is predominantly enriched at distal enhancers rather than promoters, indicating first-lineage differentiation relies on distal enhancer activity

  pre-implantation low-cell-number 8-cell zygotes cut&tag atac-seq sequencing

• The genome sequence of the sweet violet, Viola odorata L. (Malpighiales: Violaceae).

  PMID 41960579 · PMC13058574 · Wellcome open research · 2026 · 8 claims · 8 setups

  Full-text index only

  The Viola odorata genome assembly has a total length of 698.62 megabases, with 99.9% scaffolded into 10 chromosomal pseudomolecules.

  viola flow barcoding pacbio

• The genome sequence of the Eastern Pale Clouded Yellow, Colias erate (Esper, 1805) (Lepidoptera: Pieridae).

  PMID 41960581 · PMC13058573 · Wellcome open research · 2026 · 8 claims · 8 setups

  Full-text index only

  A chromosome-level genome assembly was produced for Colias erate (Eastern Pale Clouded Yellow) as part of Project Psyche.

  colias hmw pacbio hi-c

• The genome sequence of a hoverfly , Melangyna compositarum (Verrall, 1873) (Diptera: Syrphidae).

  PMID 41971599 · PMC13069379 · Wellcome open research · 2026 · 7 claims · 8 setups

  Full-text index only

  A genome assembly was generated for a single male Melangyna compositarum hoverfly specimen (idMelComo1) as part of the Darwin Tree of Life project.

  melangyna barcoding high pacbio

• The genome sequence of a rove beetle, Tachyporus hypnorum (Fabricius, 1775) (Coleoptera: Staphylinidae).

  PMID 41993728 · PMC13080330 · Wellcome open research · 2026 · 6 claims · 8 setups

  Full-text index only

  A chromosome-level genome assembly was generated for Tachyporus hypnorum, the first high-quality genome for the genus Tachyporus.

  tachyporus barcoding high pacbio

• The genome sequence of the Roundleaf geranium, Geranium rotundifolium L. (Geraniales: Geraniaceae).

  PMID 42021764 · PMC13096780 · Wellcome open research · 2026 · 8 claims · 8 setups

  Full-text index only

  The genome assembly of Geranium rotundifolium has a total length of 497.00 megabases, with 97.57% scaffolded into 13 chromosomal pseudomolecules.

  leaf silica-dried pacbio alternate flow barcoding pacbio

• The genome sequence of the Figwort Mason Wasp, Symmorphus gracilis (Brulle, 1832) (Hymenoptera: Vespidae).

  PMID 42109708 · PMC13153769 · Wellcome open research · 2026 · 6 claims · 8 setups

  Full-text index only

  A chromosome-level genome assembly was generated for Symmorphus gracilis, comprising two haplotypes (220.03 Mb and 217.14 Mb), with haplotype 1 scaffolded to 6 chromosomal pseudomolecules

  symmorphus head genomic hifi barcoding hmw pacbio

• The genome sequence of the Red-necked Footman, Atolmis rubricollis (Linnaeus, 1758) (Lepidoptera: Erebidae).

  PMID 42148442 · PMC13173283 · Wellcome open research · 2026 · 7 claims · 8 setups

  Full-text index only

  A chromosome-level genome assembly was generated for a female Atolmis rubricollis (Red-necked Footman) specimen as part of the Darwin Tree of Life project.

  atolmis barcoding pacbio hi-c

• The genome sequence of the Neglected Rustic moth, Xestia castanea (Esper, 1798) (Lepidoptera: Noctuidae).

  PMID 42148443 · PMC13179489 · Wellcome open research · 2026 · 8 claims · 8 setups

  Full-text index only

  A genome assembly was generated for a female Xestia castanea individual comprising two haplotypes of 721.78 Mb and 685.53 Mb

  xestia pacbio assembled hi-c barcoding pacbio hi-c

• The genome sequence of the flat clown beetle, Hololepta plana (Sulzer, 1776) (Coleoptera: Histeridae).

  PMID 42255359 · PMC13237540 · Wellcome open research · 2026 · 8 claims · 8 setups

  Full-text index only

  A chromosome-level genome assembly was produced for Hololepta plana (icHolPlan1) using the Darwin Tree of Life pipeline

  hololepta head abdomen hifi barcoding pacbio hi-c

• The genome sequence of the Club-Horned Wood Borer Wasp, Trypoxylon clavicerum Lepeletier de Saint Fargeau & Audinet-Serville, 1828 (Hymenoptera: Crabronidae).

  PMID 42255363 · PMC13237539 · Wellcome open research · 2026 · 8 claims · 8 setups

  Full-text index only

  A genome assembly was generated for an individual female Trypoxylon clavicerum (Club-Horned Wood Borer Wasp) as part of the Darwin Tree of Life project

  trypoxylon pacbio assembled barcoding high pacbio

• Chromosome-level genome assembly of the striped venus clam Chamelea gallina.

  PMID 41673041 · PMC13004937 · Scientific data · 2026 · 8 claims · 7 setups

  Full-text index only

  First chromosome-level genome assembly of Chamelea gallina generated using PacBio HiFi, Illumina, and Hi-C data

  gallina pacbio illumina hi-c

• The impact of haplotypes derived from Chinese pigs on genetic variation and economic traits in the Duroc breed.

  PMID 41131451 · PMC12551222 · Genetics, selection, evolution : GSE · 2025 · 8 claims · 8 setups

  Has reproduction

  Significant genetic introgression from Chinese pigs into commercial European pig lines is confirmed using SNP chip and resequencing data.

  chinese pigs duroc muscle snp genome low-coverage

• Progressive transformation of the HIV-1 reservoir cell profile over two decades of antiviral therapy.

  PMID 36596305 · PMC9839361 · Cell host & microbe · 2023 · 8 claims · 8 setups

  Has reproduction · 80

  After ~2 decades of ART, intact HIV-1 proviruses are predominantly integrated in heterochromatin, especially centromeric/peri-centromeric satellite and micro-satellite DNA

  pbmc single cd4 pbmc-derived flip-seq mip-seq prip-seq

• The GATA factor ELT-3 specifies endoderm in Caenorhabditis angaria in an ancestral gene network.

  PMID 36196618 · PMC9720673 · Development (Cambridge, England) · 2022 · 8 claims · 8 setups

  Has reproduction · 82

  Can-elt-3 (and orthologues in C. portoensis and C. monodelphis) is expressed in the early E lineage prior to elt-2 orthologue expression

  angaria elegans portoensis gata rnai single-molecule smifish

• GAVISUNK: genome assembly validation via inter-SUNK distances in Oxford Nanopore reads.

  PMID 36321867 · PMC9805576 · Bioinformatics (Oxford, England) · 2023 · 7 claims · 4 setups

  Has reproduction · 67

  GAVISUNK is an open-source pipeline that validates phased diploid HiFi assemblies by assessing concordance of inter-SUNK distances against orthogonal Oxford Nanopore (ONT) reads.

  chm13 chm1 hg02723 genome sunk haplotype

• CIRCE: a scalable Python package to predict cis-regulatory DNA interactions from single-cell chromatin accessibility data.

  PMID 41734268 · PMC12987762 · Bioinformatics (Oxford, England) · 2026 · 8 claims · 5 setups

  Full-text index only

  CIRCE re-implements the Cicero co-accessibility algorithm in Python, producing near-identical results while running much faster and using far less memory

  bmmc pbmc foetal cis-regulatory enhancer-promoter scalability

• Distinguishing benign from pathogenic duplications involving GPR101 and VGLL1-adjacent enhancers in the clinical setting with the bioinformatic tool POSTRE.

  PMID 41540017 · PMC12890961 · NPJ genomic medicine · 2026 · 6 claims · 7 setups

  Full-text index only

  POSTRE correctly classified all 34 GPR101-associated duplications (27 pathogenic X-LAG, 7 non-pathogenic) as pathogenic or benign

  anterior embryonic patient-derived genome h3k27ac atac-seq rna-seq

• pmid-41721019

  PMID 41721019 · PMC12999497 · 8 claims · 8 setups

  Full-text index only

  Premeiotic gonadal germ cells display a distinct chromosome and genome architecture concomitant with commitment to gametogenesis, involving separation of individual chromosomes, peripheral centromere anchoring, reduced interchromosomal interactions and disentangled chromosome ends

  e13.5 e9.5 gonadal facs-sorted transmission immunofluorescence minor