Matthew D. Lynes

The share of this author’s assessed papers carrying a ⚑ flag. A concentration is a prompt for expert review — never, on its own, a determination about the person.

Collaborators, sized by shared output and coloured by their own reproducibility (green = high, red = low). Click a node to open their card. A pattern is a prompt for review, never a determination.

How this author’s assessed papers reproduced — the outcome of reproduction attempts, not a judgement of the person. Coverage is partial and grows over time.

Assessed papers (5)

• Author Correction: The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue
  2026 L1 No computation
• Endogenous Fatty Acid Synthesis Drives Brown Adipose Tissue Involution
  2021 L1 No data access
• Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity
  2018 L1 88/100
• The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue
  2017 L1 78/100
• Erratum: Corrigendum: The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue
  2017 L1 No computation

5 assessed by us (2 reproduced) · 68 not yet assessed — every PubMed paper on record, linked below.

• Mass spectrometry imaging of adipose tissue lipidome maps lineage-specific metabolite profiles ↗

  Journal of Lipid Research · 2026 · PMID 41565114
  not yet assessed
• Author Correction: The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue

  Nature Medicine · 2026 · PMID 41484224
  L1 No computation
• Microenvironmentally derived fatty acid–binding proteins 4 and 5 are novel therapeutic vulnerabilities in multiple myeloma ↗

  Blood Neoplasia · 2026 · PMID 42109313
  not yet assessed
• A conserved hormonal signalling–H2A.Z axis rapidly reorganizes 3D chromatin interactions in adipocyte thermogenesis ↗

  Nature Metabolism · 2026 · PMID 42014869
  not yet assessed
• Baseline serum metabolites predict fractures in individuals who were Black and had type 2 diabetes ↗

  Frontiers in Endocrinology · 2026 · PMID 42312207
  not yet assessed
• Towards a consensus atlas of human and mouse adipose tissue at single-cell resolution ↗

  Nature Metabolism · 2025 · PMID 40360756
  not yet assessed
• Exploration of Conserved Human Adipose Subpopulations Using Targeted Single‐Nuclei RNA Sequencing Data Sets ↗

  Journal of the American Heart Association · 2025 · PMID 40094187
  not yet assessed
• Promotion of Cardiovascular Homeostasis by the Perivascular Adipose Tissue Secretome ↗

  International Journal of Molecular Sciences · 2025 · PMID 41155468
  not yet assessed
• 12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat ↗

  Cell Metabolism · 2025 · PMID 41197629
  not yet assessed
• Baseline Serum Metabolites Predict Fractures in a Subset of Accord Participants Who Were Black ↗

  SSRN Electronic Journal · 2025
  not yet assessed
• Monitoring Mouse Surface Temperature During Stress with a Thermal Camera: A Low‐Cost Infrared Videography System for Evaluating Murine Metabolism ↗

  Current Protocols · 2025 · PMID 39945421
  not yet assessed
• Brown fat ATP-citrate lyase links carbohydrate availability to thermogenesis and guards against metabolic stress ↗

  Nature Metabolism · 2024 · PMID 39402290
  not yet assessed
• Light-responsive adipose-hypothalamus axis controls metabolic regulation ↗

  Nature Communications · 2024 · PMID 39117652
  not yet assessed
• ScreenDMT reveals DiHOMEs are replicably inversely associated with BMI and stimulate adipocyte calcium influx ↗

  Communications Biology · 2024 · PMID 39143411
  not yet assessed
• Extracellular metallothionein as a therapeutic target in the early progression of type 1 diabetes ↗

  Cell Stress and Chaperones · 2024 · PMID 38490439
  not yet assessed
• #9. Inhibition of the fatty acid binding proteins (FABPs) in myeloma cells modifies their lipid composition ↗

  Journal of bone oncology · 2024
  not yet assessed
• Bioenergetics and Obesity ↗

  2024
  not yet assessed
• A CRISPR Screen Identifies the E3 Ubiquitin Ligase Rfwd2 as a Negative Regulator of Glucose Uptake in Brown Adipocytes ↗

  Genes · 2023 · PMID 37895214
  not yet assessed
• Telomerase reverse transcriptase (TERT)-expressing cells mark a novel stem cell population in the adult mouse brain ↗

  bioRxiv (Cold Spring Harbor Laboratory) · 2023
  not yet assessed
• ScreenDMT reveals linoleic acid diols replicably associate with BMI and stimulate adipocyte calcium fluxes ↗

  bioRxiv (Cold Spring Harbor Laboratory) · 2023 · PMID 37503007
  not yet assessed
• A Novel Light-Responsive Adipose-Hypothalamus Axis in Metabolic Regulation ↗

  SSRN Electronic Journal · 2023
  not yet assessed
• Bioenergetics and Obesity ↗

  2023
  not yet assessed
• Endothelial Cells Induced Progenitors Into Brown Fat to Reduce Atherosclerosis ↗

  Circulation Research · 2022 · PMID 35642564
  not yet assessed
• ADRA1A–Gαq signalling potentiates adipocyte thermogenesis through CKB and TNAP ↗

  Nature Metabolism · 2022 · PMID 36344764
  not yet assessed
• Silk Hydrogel-Mediated Delivery of Bone Morphogenetic Protein 7 Directly to Subcutaneous White Adipose Tissue Increases Browning and Energy Expenditure ↗

  Frontiers in Bioengineering and Biotechnology · 2022 · PMID 35646839
  not yet assessed
• Telomerase Reverse Transcriptase Expression Marks a Population of Rare Adipose Tissue Stem Cells ↗

  Stem Cells · 2022 · PMID 35511869
  not yet assessed
• Combined α- and β-adrenergic receptor activation triggers thermogenesis by the futile creatine cycle ↗

  Research Square · 2022
  not yet assessed
• The impact of multigenerational high-fat diet feeding on the gut microbiome and host metabolism ↗

  bioRxiv (Cold Spring Harbor Laboratory) · 2022
  not yet assessed
• Defining the lineage of thermogenic perivascular adipose tissue ↗

  Nature Metabolism · 2021 · PMID 33846639
  not yet assessed
• Vascular smooth muscle-derived Trpv1+ progenitors are a source of cold-induced thermogenic adipocytes ↗

  Nature Metabolism · 2021 · PMID 33846638
  not yet assessed
• Endogenous Fatty Acid Synthesis Drives Brown Adipose Tissue Involution

  Cell Reports · 2021 · PMID 33440156
  L1 No data access
• 1207-P: Tracing Telomerase Reverse Transcriptase (Tert) Expression to a Dormant Preadipogenic Origin ↗

  Diabetes · 2021
  not yet assessed
• CRISPR-engineered human brown-like adipocytes prevent diet-induced obesity and ameliorate metabolic syndrome in mice ↗

  Science Translational Medicine · 2020 · PMID 32848096
  not yet assessed
• FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis ↗

  Nature Communications · 2020 · PMID 32184391
  not yet assessed
• Cell-autonomous light sensitivity via Opsin3 regulates fuel utilization in brown adipocytes ↗

  PLoS Biology · 2020 · PMID 32040503
  not yet assessed
• Brown Fat–Activating Lipokine 12,13-diHOME in Human Milk Is Associated With Infant Adiposity ↗

  The Journal of Clinical Endocrinology & Metabolism · 2020 · PMID 33135728
  not yet assessed
• Integrated metabolomics reveals altered lipid metabolism in adipose tissue in a model of extreme longevity ↗

  GeroScience · 2020 · PMID 32632845
  not yet assessed
• Commentary on: “The Presence of Active Brown Adipose Tissue Determines Cold-Induced Energy Expenditure and Oxylipin Profiles in Humans” ↗

  The Journal of Clinical Endocrinology & Metabolism · 2020 · PMID 32559764
  not yet assessed
• Vascular smooth muscle-derived TRPV1-expressing progenitors are a new source of cold-induced thermogenic adipocytes ↗

  bioRxiv (Cold Spring Harbor Laboratory) · 2020
  not yet assessed
• 1701-P: The Role of UGT1a in Regulating Brown Adipose Tissue and Thermogenic Function ↗

  Diabetes · 2020
  not yet assessed
• TGF-β2 is an exercise-induced adipokine that regulates glucose and fatty acid metabolism ↗

  Nature Metabolism · 2019 · PMID 31032475
  not yet assessed
• 12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat ↗

  Cell Metabolism · 2019 · PMID 31353262
  not yet assessed
• Lipokines and Thermogenesis ↗

  Endocrinology · 2019 · PMID 31504387
  not yet assessed
• 192-OR: A CRISPR Screen Identifies Rfwd2 as a Regulator of Brown Fat Glucose Transport ↗

  Diabetes · 2019
  not yet assessed
• 1999-P: Cysteine-Rich Protein 2 (CRIP2) Is a Novel Transcriptional Regulator of Uncoupling Protein 1 ↗

  Diabetes · 2019
  not yet assessed
• 12,13-diHOME: An Exercise-Induced Lipokine that Increases Skeletal Muscle Fatty Acid Uptake ↗

  Cell Metabolism · 2018 · PMID 29719226
  not yet assessed
• Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity

  Nature Medicine · 2018 · PMID 29400713
  L1 88/100
• Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis ↗

  Cell Metabolism · 2018 · PMID 29861389
  not yet assessed
• Cold-Activated Lipid Dynamics in Adipose Tissue Highlights a Role for Cardiolipin in Thermogenic Metabolism ↗

  Cell Reports · 2018 · PMID 30021173
  not yet assessed
• 12,13-diHOME: An Exercise-Induced Lipokine that Increases Skeletal Muscle Fatty Acid Uptake ↗

  Cell Metabolism · 2018
  not yet assessed
• Adapted MS/MSALL Shotgun Lipidomics Approach for Analysis of Cardiolipin Molecular Species ↗

  Lipids · 2018 · PMID 29488636
  not yet assessed
• Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity

  DSpace@MIT (Massachusetts Institute of Technology) · 2018
  not yet assessed
• The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue

  Nature Medicine · 2017 · PMID 28346411
  L1 78/100
• Deciphering adipose tissue heterogeneity ↗

  Annals of the New York Academy of Sciences · 2017 · PMID 28763833
  not yet assessed
• Reestablishment of Energy Balance in a Male Mouse Model With POMC Neuron Deletion of BMPR1A ↗

  Endocrinology · 2017 · PMID 29040444
  not yet assessed
• Integrating Extracellular Flux Measurements and Genome-Scale Modeling Reveals Differences between Brown and White Adipocytes ↗

  Cell Reports · 2017 · PMID 29241534
  not yet assessed
• Erratum: Corrigendum: The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue

  Nature Medicine · 2017 · PMID 29117173
  L1 No computation
• Connexin 43 Mediates White Adipose Tissue Beiging by Facilitating the Propagation of Sympathetic Neuronal Signals ↗

  Cell Metabolism · 2016 · PMID 27626200
  not yet assessed
• Monoacylglycerol Analysis Using MS/MSALL Quadruple Time of Flight Mass Spectrometry ↗

  Metabolites · 2016 · PMID 27548241
  not yet assessed
• Loss of BMP receptor type 1A in murine adipose tissue attenuates age-related onset of insulin resistance ↗

  Diabetologia · 2016 · PMID 27209464
  not yet assessed
• Clonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes ↗

  Nature Medicine · 2015 · PMID 26076036
  not yet assessed
• Curcumin analogues as selective fluorescence imaging probes for brown adipose tissue and monitoring browning ↗

  Scientific Reports · 2015 · PMID 26269357
  not yet assessed
• Disruption of Insulin Signaling in Myf5-Expressing Progenitors Leads to Marked Paucity of Brown Fat but Normal Muscle Development ↗

  Endocrinology · 2015 · PMID 25625589
  not yet assessed
• The thermogenic circuit: Regulators of thermogenic competency and differentiation ↗

  Genes & Diseases · 2015 · PMID 26491708
  not yet assessed
• Isolation of Progenitors that Exhibit Myogenic/Osteogenic Bipotency In Vitro by Fluorescence-Activated Cell Sorting from Human Fetal Muscle ↗

  Stem Cell Reports · 2014 · PMID 24678452
  not yet assessed
• Isolation of Progenitors that Exhibit Myogenic/Osteogenic Bipotency In Vitro by Fluorescence-Activated Cell Sorting from Human Fetal Muscle ↗

  Stem Cell Reports · 2014
  not yet assessed
• Unwiring the transcriptional heat circuit ↗

  Proceedings of the National Academy of Sciences · 2014 · PMID 25261553
  not yet assessed
• Increased Mitochondrial Activity in BMP7-Treated Brown Adipocytes, Due to Increased CPT1- and CD36-Mediated Fatty Acid Uptake ↗

  Antioxidants and Redox Signaling · 2012 · PMID 22938691
  not yet assessed
• Control of CD36 phosphorylation by global intestinal alkaline phosphatase mediates intestinal adaptation to high-fat diet

  OpenBU (Boston University) · 2012
  not yet assessed
• Interactions between CD36 and global intestinal alkaline phosphatase in mouse small intestine and effects of high-fat diet ↗

  American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · 2011 · PMID 21900644
  not yet assessed
• Increased Capacity of Distal Intestinal Epithelium to Transport Long-Chain Fatty Acids in Obese Mice Fed a High-Fat Diet ↗

  2011
  not yet assessed
• Involvement of CD36 and intestinal alkaline phosphatases in fatty acid transport in enterocytes, and the response to a high-fat diet ↗

  Life Sciences · 2010 · PMID 21172358
  not yet assessed
• Gene profiling of scleroderma skin reveals robust signatures of disease that are imperfectly reflected in the transcript profiles of explanted fibroblasts ↗

  Arthritis & Rheumatism · 2006 · PMID 16736506
  not yet assessed