Christian Schlein

The share of this author’s assessed papers carrying a ⚑ flag. A concentration is a prompt for expert review — never, on its own, a determination about the person.

Collaborators, sized by shared output and coloured by their own reproducibility (green = high, red = low). Click a node to open their card. A pattern is a prompt for review, never a determination.

How this author’s assessed papers reproduced — the outcome of reproduction attempts, not a judgement of the person. Coverage is partial and grows over time.

Assessed papers (35)

• Author Correction: The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue
  2026 L1 No computation
• Structural modeling and functional characterization of a novel gain-of-function TLR8 variant causing severe inflammatory syndrome
  2026 L1 89/100
• Pleiotropic effects of <i>MORC2</i> derive from its epigenetic signature
  2025 L1 No data access
• Covalent binding of thioredoxin to TXNIP is required for diet-induced insulin resistance in the liver.
  2025 L1 87/100
• Author Correction: Next-generation phenotyping integrated in a national framework for patients with ultrarare disorders improves genetic diagnostics and yields new molecular findings
  2025 L1 76/100
• Evaluating genome sequencing strategies: trio, singleton, and standard testing in rare disease diagnosis
  2025 L1 88/100
• Thoracic aortic diseases: Identification of diagnostic biomarkers using proteomic analysis⚑
  2025 L1 23/100 ⚑
• Purinergic adipocyte-macrophage crosstalk promotes degeneration of thermogenic brown adipose tissue
  2025 L1 78/100
• Fatty acid synthesis suppresses dietary polyunsaturated fatty acid use
  2024 L1 94/100
• Intergenic risk variant rs56258221 skews the fate of naive CD4+ T cells via miR4464-BACH2 interplay in primary sclerosing cholangitis
  2024 L1 58/100
• Next-generation phenotyping integrated in a national framework for patients with ultrarare disorders improves genetic diagnostics and yields new molecular findi
  2024 L1 87/100
• Variants in LRRC7 lead to intellectual disability, autism, aggression and abnormal eating behaviors
  2024 L1 87/100
• Cold-Induced Lipoprotein Clearance in Cyp7b1-Deficient Mice
  2022 L1 83/100
• Apoptotic brown adipocytes enhance energy expenditure via extracellular inosine
  2022 L1 57/100
• Clinical and pathological characteristics of familial melanoma with germline <scp><i>TERT</i></scp> promoter variants
  2022 L1 No computation
• Endogenous Fatty Acid Synthesis Drives Brown Adipose Tissue Involution
  2021 L1 No data access
• TFEB deficiency attenuates mitochondrial degradation upon brown adipose tissue whitening at thermoneutrality
  2021 L1 No computation
• Brown adipose tissue lipoprotein and glucose disposal is not determined by thermogenesis in uncoupling protein 1-deficient mice
  2020 L1 No computation
• Effects of Pharmacological Thermogenic Adipocyte Activation on Metabolism and Atherosclerotic Plaque Regression
  2019 L1 No computation
• PID1 regulates insulin-dependent glucose uptake by controlling intracellular sorting of GLUT4-storage vesicles
  2019 L1 No computation
• Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity
  2018 L1 88/100
• FoxO transcription factors are required for hepatic HDL cholesterol clearance
  2018 L1 49/100
• Course of HEV viremia and anti-HEV IgM/IgG response in asymptomatic blood donors
  2018 L1 No computation
• Lipolysis Triggers a Systemic Insulin Response Essential for Efficient Energy Replenishment of Activated Brown Adipose Tissue in Mice
  2018 L1 No computation
• Intact innervation is essential for diet-induced recruitment of brown adipose tissue
  2018 L1 No computation
• The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue
  2017 L1 78/100
• Thermogenic adipocytes promote HDL turnover and reverse cholesterol transport
  2017 L1 No computation
• Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive thermogenesis
  2017 No data access
• Erratum: Corrigendum: The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue
  2017 L1 No computation
• FGF21 Lowers Plasma Triglycerides by Accelerating Lipoprotein Catabolism in White and Brown Adipose Tissues
  2016 L1 No computation
• Exosomal microRNA miR-92a concentration in serum reflects human brown fat activity
  2016 L1 97/100
• Implications of thermogenic adipose tissues for metabolic health
  2016 L1 No computation
• Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development
  2015 L1 No computation
• Genetic Dissection of Tissue-Specific Apolipoprotein E Function for Hypercholesterolemia and Diet-Induced Obesity
  2015 L1 No computation
• Homozygosity for a partial deletion of apoprotein A-V signal peptide results in intracellular missorting of the protein and chylomicronemia in a breast-fed infant
  2014 L1 No computation

35 assessed by us (12 reproduced) · 32 not yet assessed — every PubMed paper on record, linked below.

• Author Correction: The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue

  Nature Medicine · 2026 · PMID 41484224
  L1 No computation
• Structural modeling and functional characterization of a novel gain-of-function TLR8 variant causing severe inflammatory syndrome

  JCI Insight · 2026 · PMID 41729082
  L1 89/100
• The conjugation-resistant bile acid norUDCA cures liver fibrosis but impairs systemic energy metabolism ↗

  Molecular Metabolism · 2026 · PMID 41935828
  not yet assessed
• Structural modeling and functional characterization of a novel gain-of-function TLR8 variant causing severe inflammatory syndrome ↗

  DESY Publication Database (PUBDB) (Deutsches Elektronen-Synchrotron) · 2026
  not yet assessed
• Mitochondrial diabetes mellitus: real world insights from the GENOMIT registry–a multinational, longitudinal cohort study ↗

  EBioMedicine · 2026 · PMID 42679752
  not yet assessed
• Evaluating genome sequencing strategies: trio, singleton, and standard testing in rare disease diagnosis

  Genome Medicine · 2025 · PMID 40963120
  L1 88/100
• Pleiotropic effects of MORC2 derive from its epigenetic signature

  Brain · 2025 · PMID 40302207
  L1 No data access
• Covalent binding of thioredoxin to TXNIP is required for diet-induced insulin resistance in the liver

  Journal of Biological Chemistry · 2025 · PMID 40345590
  L1 87/100
• Purinergic adipocyte-macrophage crosstalk promotes degeneration of thermogenic brown adipose tissue

  EMBO Reports · 2025 · PMID 41261284
  L1 78/100
• TXNIP is a critical regulator of human cardiometabolic health ↗

  medRxiv · 2025
  not yet assessed
• Clinical and Histological Predictors of Aortic Distensibility in Patients with Thoracic Aortic Aneurysms ↗

  The Thoracic and Cardiovascular Surgeon · 2025
  not yet assessed
• Purinergic adipocyte-macrophage crosstalk promotes degeneration of thermogenic brown adipose tissue ↗

  Research Square · 2025
  not yet assessed
• Author Correction: Next-generation phenotyping integrated in a national framework for patients with ultrarare disorders improves genetic diagnostics and yields new molecular findings

  Nature Genetics · 2025 · PMID 40555819
  L1 76/100
• A simple, cost efficient assay for assessing the functional impact of single and multi-gene variant combinations ↗

  bioRxiv (Cold Spring Harbor Laboratory) · 2025
  not yet assessed
• Thoracic aortic diseases: Identification of diagnostic biomarkers using proteomic analysis⚑

  Cardiovascular Pathology · 2025 · PMID 41061941
  L1 23/100 ⚑
• Maternal IGHG locus duplications impair infants’ passive immunity ↗

  medRxiv · 2025
  not yet assessed
• Sympathetic signaling directs macrophage efferocytosis in thermogenic adipose tissue ↗

  bioRxiv (Cold Spring Harbor Laboratory) · 2025
  not yet assessed
• The conjugation-resistant bile acid norUDCA cures liver fibrosis but impairs systemic energy metabolism ↗

  Research Square · 2025
  not yet assessed
• Author Correction: Next-generation phenotyping integrated in a national framework for patients with ultrarare disorders improves genetic diagnostics and yields new molecular findings

  RWTH Publications (RWTH Aachen) · 2025
  not yet assessed
• Fatty acid synthesis suppresses dietary polyunsaturated fatty acid use

  Nature Communications · 2024 · PMID 38167725
  L1 94/100
• Next-generation phenotyping integrated in a national framework for patients with ultrarare disorders improves genetic diagnostics and yields new molecular findings

  Nature Genetics · 2024 · PMID 39039281
  L1 87/100
• Variants in LRRC7 lead to intellectual disability, autism, aggression and abnormal eating behaviors

  Nature Communications · 2024 · PMID 39256359
  L1 87/100
• Intergenic risk variant rs56258221 skews the fate of naive CD4+ T cells via miR4464-BACH2 interplay in primary sclerosing cholangitis

  Cell Reports Medicine · 2024 · PMID 38901430
  L1 58/100
• Evaluating Genome Sequencing Strategies: Trio, Singleton, and Standard Testing in Rare Disease Diagnosis ↗

  medRxiv · 2024
  not yet assessed
• Control of cholesterol-induced adipocyte inflammation by the Nfe2l1-Atf3 pathway ↗

  bioRxiv (Cold Spring Harbor Laboratory) · 2024
  not yet assessed
• Aortic Elasticity and Histological Patterns in Male vs. Female Patients with Aortopathy ↗

  The Thoracic and Cardiovascular Surgeon · 2024
  not yet assessed
• Thoracic Aortic Diseases: Identification of Diagnostic Biomarkers Using Proteomic Analysis ↗

  The Thoracic and Cardiovascular Surgeon · 2024
  not yet assessed
• Histological Patterns and Aortic Elasticity in Bicuspid vs. Tricuspid Aortopathy ↗

  The Thoracic and Cardiovascular Surgeon · 2024
  not yet assessed
• Next-generation phenotyping integrated in a national framework for patients with ultra-rare disorders improves genetic diagnostics and yields new molecular findings ↗

  medRxiv · 2023
  not yet assessed
• Fatty acid synthesis suppresses dietary polyunsaturated fatty acid use ↗

  Research Square · 2023
  not yet assessed
• Mitochondrial fatty acid synthesis is essential for coordinated energy transformation ↗

  medRxiv · 2023
  not yet assessed
• Fatty acid synthesis suppresses dietary polyunsaturated fatty acid use ↗

  Research Square · 2023
  not yet assessed
• Apoptotic brown adipocytes enhance energy expenditure via extracellular inosine

  Nature · 2022 · PMID 35790189
  L1 57/100
• Cold-Induced Lipoprotein Clearance in Cyp7b1-Deficient Mice

  Frontiers in Cell and Developmental Biology · 2022 · PMID 35478959
  L1 83/100
• Clinical and pathological characteristics of familial melanoma with germline TERT promoter variants

  Pigment Cell & Melanoma Research · 2022 · PMID 35912549
  L1 No computation
• Fatty acid synthesis suppresses dietary polyunsaturated fatty acid use ↗

  Research Square · 2022
  not yet assessed
• Endogenous Fatty Acid Synthesis Drives Brown Adipose Tissue Involution

  Cell Reports · 2021 · PMID 33440156
  L1 No data access
• TFEB deficiency attenuates mitochondrial degradation upon brown adipose tissue whitening at thermoneutrality

  Molecular Metabolism · 2021 · PMID 33516944
  L1 No computation
• Characterization of Genetic and Metabolic Somatic Events in Aortic Atherosclerotic Plaques ↗

  The Thoracic and Cardiovascular Surgeon · 2021
  not yet assessed
• Lysosomal lipoprotein processing in endothelial cells stimulates adipose tissue thermogenic adaptation ↗

  Cell Metabolism · 2020 · PMID 33357458
  not yet assessed
• Brown adipose tissue lipoprotein and glucose disposal is not determined by thermogenesis in uncoupling protein 1-deficient mice

  Journal of Lipid Research · 2020 · PMID 32769145
  L1 No computation
• Thermoneutrality-Induced Macrophage Accumulation in Brown Adipose Tissue Does Not Impair the Tissue’s Competence for Cold-Induced Thermogenic Recruitment ↗

  Frontiers in Endocrinology · 2020 · PMID 33193086
  not yet assessed
• Lysosomal Lipoprotein Processing in Endothelial Cells Stimulates Adipose Tissue Browning ↗

  SSRN Electronic Journal · 2020
  not yet assessed
• PID1 regulates insulin-dependent glucose uptake by controlling intracellular sorting of GLUT4-storage vesicles

  Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 2019 · PMID 30904610
  L1 No computation
• Effects of Pharmacological Thermogenic Adipocyte Activation on Metabolism and Atherosclerotic Plaque Regression

  Nutrients · 2019 · PMID 30813320
  L1 No computation
• Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity

  Nature Medicine · 2018 · PMID 29400713
  L1 88/100
• Lipolysis Triggers a Systemic Insulin Response Essential for Efficient Energy Replenishment of Activated Brown Adipose Tissue in Mice

  Cell Metabolism · 2018 · PMID 30033199
  L1 No computation
• Intact innervation is essential for diet-induced recruitment of brown adipose tissue

  American Journal of Physiology-Endocrinology and Metabolism · 2018 · PMID 30576247
  L1 No computation
• Course of HEV viremia and anti-HEV IgM/IgG response in asymptomatic blood donors

  Journal of Clinical Virology · 2018 · PMID 29860111
  L1 No computation
• FoxO transcription factors are required for hepatic HDL cholesterol clearance

  Journal of Clinical Investigation · 2018 · PMID 29408809
  L1 49/100
• Lipolysis Triggers a Systemic Insulin Response Essential for Efficient Energy Replenishment of Activated Brown Adipose Tissue in Mice ↗

  SSRN Electronic Journal · 2018
  not yet assessed
• Verlauf von HEV-Virämie und anti-HEV IgM/IgG-Antwort bei 27 immunkompetenten Blutspendern ↗

  Zeitschrift für Gastroenterologie · 2018
  not yet assessed
• Increased hepatic bile acid production shapes the gut microbiome after cold induced brown adipose tissue activation ↗

  Atherosclerosis · 2018
  not yet assessed
• Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity

  DSpace@MIT (Massachusetts Institute of Technology) · 2018
  not yet assessed
• The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue

  Nature Medicine · 2017 · PMID 28346411
  L1 78/100
• Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive thermogenesis

  Nature Medicine · 2017 · PMID 28604703
  No data access
• Thermogenic adipocytes promote HDL turnover and reverse cholesterol transport

  Nature Communications · 2017 · PMID 28422089
  L1 No computation
• Erratum: Corrigendum: The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue

  Nature Medicine · 2017 · PMID 29117173
  L1 No computation
• Abstract 190: The Role of Hepatic FoxO Transcription Factors in HDL-Mediated Reverse Cholesterol Transport ↗

  Arteriosclerosis Thrombosis and Vascular Biology · 2017
  not yet assessed
• FGF21 Lowers Plasma Triglycerides by Accelerating Lipoprotein Catabolism in White and Brown Adipose Tissues

  Cell Metabolism · 2016 · PMID 26853749
  L1 No computation
• Exosomal microRNA miR-92a concentration in serum reflects human brown fat activity

  Nature Communications · 2016 · PMID 27117818
  L1 97/100
• Implications of thermogenic adipose tissues for metabolic health

  Best Practice & Research Clinical Endocrinology & Metabolism · 2016 · PMID 27697210
  L1 No computation
• FGF21 lowers plasma triglycerides by accelerating lipoprotein catabolism in white and brown adipose tissues ↗

  Atherosclerosis · 2016
  not yet assessed
• Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development

  Nature Communications · 2015 · PMID 25754609
  L1 No computation
• Genetic Dissection of Tissue-Specific Apolipoprotein E Function for Hypercholesterolemia and Diet-Induced Obesity

  PLoS ONE · 2015 · PMID 26695075
  L1 No computation
• Homozygosity for a partial deletion of apoprotein A-V signal peptide results in intracellular missorting of the protein and chylomicronemia in a breast-fed infant

  Atherosclerosis · 2014 · PMID 24529129
  L1 No computation
• Linking white-to-brown fat remodeling to fatty acid and lipoprotein metabolism ↗

  Atherosclerosis · 2014
  not yet assessed