Hans‐Jürgen Kreienkamp
Reproducibility track record
2
assessed papers
87/100
mean reproducibility
1
reproduced (C1–C2)
0
flagged
0
total citations
flag rate:
0%
(0/2)
The share of this author’s assessed papers carrying a ⚑ flag. A concentration is a prompt for expert review — never, on its own, a determination about the person.
Authorship role
first author: 0
last author: 1
Topics
—
Funders
—
Frequent co-authors
Michelle L. Thompson 1Alain Verloès 1Krista Schatz 1Christian Schlein 1Fatemeh Hassani Nia 1Michael Zech 1Konrad Platzer 1Erica E. Davis 1Kristin Barañano 1David P Wolfer 1
Institutions
Universität Hamburg 2University Medical Center Hamburg-Eppendorf 2Icahn School of Medicine at Mount Sinai 1Washington University in St. Louis 1Helmholtz Zentrum München 1Institute for Advanced Study 1
Geography (author institutions)
DE 2NL 2US 1FR 1DK 1BE 1
Co-author network
Collaborators, sized by shared output and coloured by their own reproducibility (green = high, red = low). Click a node to open their card. A pattern is a prompt for review, never a determination.
How this author’s assessed papers reproduced — the outcome of reproduction attempts, not a judgement of the person. Coverage is partial and grows over time.
Assessed papers (2)
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Variants in LRRC7 lead to intellectual disability, autism, aggression and abnormal eating behaviors
2024 L1 87/100
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Dysregulation of Rho GTPases in the αPix/Arhgef6 mouse model of X-linked intellectual disability is paralleled by impaired structural and synaptic plasticity and cognitive deficits.
2012 L1 No computation
Complete publication record (124)
Request a reproduction →2 assessed by us (1 reproduced) · 122 not yet assessed — every PubMed paper on record, linked below.
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An internal PDZ-binding motif in Densin-180 promotes activity-dependent SHANK scaffold remodelling ↗bioRxiv (Cold Spring Harbor Laboratory) · 2026not yet assessed
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Dysregulation of AGO2-miRNA dynamics underlies the <i>AGO2</i>-associated Lessel–Kreienkamp syndrome ↗Nucleic Acids Research · 2025 · PMID 41099708not yet assessed
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Patient‐Derived Variants Define Constraints for Ligand Binding at the <scp>PDZ</scp> Domain of <scp>CASK</scp> ↗Journal of Neurochemistry · 2025 · PMID 41321276not yet assessed
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Somatostatin receptors in GtoPdb v.2025.3 ↗IUPHAR/BPS Guide to Pharmacology CITE · 2025not yet assessed
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Variants in LRRC7 lead to intellectual disability, autism, aggression and abnormal eating behaviorsNature Communications · 2024 · PMID 39256359L1 87/100
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The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors ↗British Journal of Pharmacology · 2023 · PMID 38123151not yet assessed
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The Shank/ProSAP N-Terminal (SPN) Domain of Shank3 Regulates Targeting to Postsynaptic Sites and Postsynaptic Signaling ↗Molecular Neurobiology · 2023 · PMID 37656313not yet assessed
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The Shank/ProSAP N-terminal (SPN) domain of Shank3 regulates targeting to postsynaptic sites and postsynaptic signalling ↗bioRxiv (Cold Spring Harbor Laboratory) · 2023not yet assessed
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Somatostatin receptors in GtoPdb v.2023.1 ↗IUPHAR/BPS Guide to Pharmacology CITE · 2023not yet assessed
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Structural deficits in key domains of Shank2 lead to alterations in postsynaptic nanoclusters and to a neurodevelopmental disorder in humans ↗Molecular Psychiatry · 2022 · PMID 36450866not yet assessed
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Regulation of Liprin-α phase separation by CASK is disrupted by a mutation in its CaM kinase domain ↗Life Science Alliance · 2022 · PMID 36137748not yet assessed
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Mutations affecting the N-terminal domains of SHANK3 point to different pathomechanisms in neurodevelopmental disorders ↗Scientific Reports · 2022 · PMID 35042901not yet assessed
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Regulation of Liprin-α phase separation by CASK is disrupted by a mutation in its CaM kinase domain ↗bioRxiv (Cold Spring Harbor Laboratory) · 2022not yet assessed
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THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors ↗British Journal of Pharmacology · 2021 · PMID 34529832not yet assessed
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Autism-associated SHANK3 missense point mutations impact conformational fluctuations and protein turnover at synapses ↗eLife · 2021 · PMID 33945465not yet assessed
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SHANK3 conformation regulates direct actin binding and crosstalk with Rap1 signaling ↗Current Biology · 2021 · PMID 34610274not yet assessed
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Variant-specific effects define the phenotypic spectrum of HNRNPH2-associated neurodevelopmental disorders in males ↗Human Genetics · 2021 · PMID 34907471not yet assessed
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Functional analysis of CASK transcript variants expressed in human brain ↗PLoS ONE · 2021 · PMID 34133460not yet assessed
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The Golgi-Associated PDZ Domain Protein Gopc/PIST Is Required for Synaptic Targeting of mGluR5 ↗Molecular Neurobiology · 2021 · PMID 34383253not yet assessed
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SHANK3 Conformation Regulates Direct Actin Binding and Crosstalk With Rap1 Signaling ↗SSRN Electronic Journal · 2021not yet assessed
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Autism associated <i>SHANK3</i> missense point mutations impact conformational fluctuations and protein turnover at synapses ↗bioRxiv (Cold Spring Harbor Laboratory) · 2021not yet assessed
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Mutations affecting the N-terminal domains of SHANK3 point to different pathomechanisms in neurodevelopmental disorders ↗bioRxiv (Cold Spring Harbor Laboratory) · 2021not yet assessed
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not yet assessed
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Additional file 2 of Genotype–phenotype correlations and novel molecular insights into the DHX30-associated neurodevelopmental disorders ↗Open MIND · 2021not yet assessed
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Germline AGO2 mutations impair RNA interference and human neurological development ↗Nature Communications · 2020 · PMID 33199684not yet assessed
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Missense mutations in <i>CASK,</i> coding for the calcium‐/calmodulin‐dependent serine protein kinase, interfere with neurexin binding and neurexin‐induced oligomerization ↗Journal of Neurochemistry · 2020 · PMID 33090494not yet assessed
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Truncating mutations in <i>SHANK3</i> associated with global developmental delay interfere with nuclear β‐catenin signaling ↗Journal of Neurochemistry · 2020 · PMID 32202324not yet assessed
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Targeting of δ-catenin to postsynaptic sites through interaction with the Shank3 N-terminus ↗Molecular Autism · 2020 · PMID 33115499not yet assessed
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Characterization of agonist-dependent somatostatin receptor subtype 2 trafficking in neuroendocrine cells ↗Endocrine · 2020 · PMID 32383089not yet assessed
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Conformational dynamics regulate SHANK3 actin and Rap1 binding ↗bioRxiv (Cold Spring Harbor Laboratory) · 2020not yet assessed
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Genotype–phenotype correlations and novel molecular insights into the <i>DHX30</i> -associated neurodevelopmental disorders ↗medRxiv · 2020not yet assessed
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Cognitive impairment and autistic-like behaviour in SAPAP4-deficient mice ↗Translational Psychiatry · 2019 · PMID 30664629not yet assessed
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Somatostatin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database ↗IUPHAR/BPS Guide to Pharmacology CITE · 2019not yet assessed
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Biochemie hoch2: und Molekularbiologie2019not yet assessed
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International Union of Basic and Clinical Pharmacology. CV. Somatostatin Receptors: Structure, Function, Ligands, and New Nomenclature ↗Pharmacological Reviews · 2018 · PMID 30232095not yet assessed
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Functional Relevance of Missense Mutations Affecting the N-Terminal Part of Shank3 Found in Autistic Patients ↗Frontiers in Molecular Neuroscience · 2018 · PMID 30131675not yet assessed
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De Novo Missense Mutations in DHX30 Impair Global Translation and Cause a Neurodevelopmental Disorder ↗The American Journal of Human Genetics · 2018not yet assessed
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SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras ↗Nature Cell Biology · 2017 · PMID 28263956not yet assessed
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De Novo Missense Mutations in DHX30 Impair Global Translation and Cause a Neurodevelopmental Disorder ↗The American Journal of Human Genetics · 2017 · PMID 29100085not yet assessed
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Heterodimerization with the β 1 subunit directs the α 2 subunit of nitric oxide-sensitive guanylyl cyclase to calcium-insensitive cell-cell contacts in HEK293 cells: Interaction with Lin7a ↗Biochemical Pharmacology · 2016 · PMID 27793718not yet assessed
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The Golgi-associated PDZ Domain Protein PIST/GOPC Stabilizes the β1-Adrenergic Receptor in Intracellular Compartments after Internalization ↗Journal of Biological Chemistry · 2015 · PMID 25614626not yet assessed
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Severe learning deficits of <scp>IRS</scp>p53 mutant mice are caused by altered <scp>NMDA</scp> receptor‐dependent signal transduction ↗Journal of Neurochemistry · 2015 · PMID 26560964not yet assessed
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Sharpin Controls Osteogenic Differentiation of Mesenchymal Bone Marrow Cells ↗The Journal of Immunology · 2015 · PMID 26363054not yet assessed
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Correction: Eps8 Regulates Axonal Filopodia in Hippocampal Neurons in Response to Brain-Derived Neurotrophic Factor (BDNF) ↗PLoS Biology · 2015not yet assessed
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Subcellular Sorting of the G-Protein Coupled Mouse Somatostatin Receptor 5 by a Network of PDZ-Domain Containing Proteins ↗PLoS ONE · 2014 · PMID 24523912not yet assessed
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A Non-Canonical Initiation Site Is Required for Efficient Translation of the Dendritically Localized Shank1 mRNA ↗PLoS ONE · 2014 · PMID 24533096not yet assessed
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SHANK3 Gene Mutations Associated with Autism Facilitate Ligand Binding to the Shank3 Ankyrin Repeat Region ↗Journal of Biological Chemistry · 2013 · PMID 23897824not yet assessed
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Dendritic mRNA Targeting and Translation ↗Advances in experimental medicine and biology · 2012 · PMID 22351061not yet assessed
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Sharpin Contributes to TNFα Dependent NFκB Activation and Anti-Apoptotic Signalling in Hepatocytes ↗PLoS ONE · 2012 · PMID 22253853not yet assessed
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Association of Shank 1A Scaffolding Protein with Cone Photoreceptor Terminals in the Mammalian Retina ↗PLoS ONE · 2012 · PMID 22984429not yet assessed
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The<scp>RNA</scp>‐binding protein<scp>MARTA</scp>2 regulates dendritic targeting of<scp>MAP</scp>2<scp>mRNA</scp>s in rat neurons ↗Journal of Neurochemistry · 2012 · PMID 23121659not yet assessed
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Regional and subcellular distribution of the receptor‐targeting protein PIST in the rat central nervous system ↗The Journal of Comparative Neurology · 2012not yet assessed
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Dysregulation of Rho GTPases in the αPix/Arhgef6 mouse model of X-linked intellectual disability is paralleled by impaired structural and synaptic plasticity and cognitive deficitsHuman Molecular Genetics · 2011 · PMID 21989057L1 No computation
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Autosomal-Recessive Posterior Microphthalmos Is Caused by Mutations in PRSS56, a Gene Encoding a Trypsin-Like Serine Protease ↗The American Journal of Human Genetics · 2011 · PMID 21397065not yet assessed
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Somatostatin receptor 5 is palmitoylated by the interacting ZDHHC5 palmitoyltransferase ↗FEBS Letters · 2011 · PMID 21820437not yet assessed
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Somatostatin Inhibits Cell Migration and Reduces Cell Counts of Human Keratinocytes and Delays Epidermal Wound Healing in an Ex Vivo Wound Model ↗PLoS ONE · 2011 · PMID 21589940not yet assessed
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Regional and subcellular distribution of the receptor‐targeting protein PIST in the rat central nervous system ↗The Journal of Comparative Neurology · 2011 · PMID 21953547not yet assessed
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The Role of the Postsynaptic Density in the Pathology of the Fragile X Syndrome ↗Results and problems in cell differentiation · 2011 · PMID 22009348not yet assessed
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Somatostatin regulates tight junction function and composition in human keratinocytes ↗Experimental Dermatology · 2010 · PMID 20629740not yet assessed
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Fragile X Mental Retardation Protein Regulates the Levels of Scaffold Proteins and Glutamate Receptors in Postsynaptic Densities ↗Journal of Biological Chemistry · 2009 · PMID 19640847not yet assessed
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The Insulin Receptor Substrate of 53 kDa (IRSp53) Limits Hippocampal Synaptic Plasticity ↗Journal of Biological Chemistry · 2009 · PMID 19208628not yet assessed
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Shank1 mRNA: Dendritic Transport by Kinesin and Translational Control by the 5′Untranslated Region ↗Traffic · 2009 · PMID 19416473not yet assessed
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Dendritic mRNA Targeting of Jacob and N-Methyl-d-aspartate-induced Nuclear Translocation after Calpain-mediated Proteolysis ↗Journal of Biological Chemistry · 2009 · PMID 19608740not yet assessed
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Eps8 Regulates Axonal Filopodia in Hippocampal Neurons in Response to Brain-Derived Neurotrophic Factor (BDNF)DSpace@MIT (Massachusetts Institute of Technology) · 2009not yet assessed
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Scaffolding Proteins at the Postsynaptic Density: Shank as the Architectural Framework ↗Handbook of experimental pharmacology · 2008 · PMID 18491060not yet assessed
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Interaction of the human somatostatin receptor 3 with the multiple PDZ domain protein MUPP1 enables somatostatin to control permeability of epithelial tight junctions ↗FEBS Letters · 2008 · PMID 19071123not yet assessed
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p.Gln200Glu, a putative constitutively active mutant of rod α-transducin (GNAT1) in autosomal dominant congenital stationary night blindness ↗Human Mutation · 2007 · PMID 17584859not yet assessed
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Interaction of brain somatostatin receptors with the PDZ domains of PSD‐95 ↗FEBS Letters · 2007 · PMID 17950729not yet assessed
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Elevated phenylalanine levels interfere with neurite outgrowth stimulated by the neuronal cell adhesion molecule L1 in vitro ↗FEBS Letters · 2006 · PMID 16716305not yet assessed
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Physiology of Somatostatin Receptors: From Genetics to Molecular Analysis ↗Kluwer Academic Publishers eBooks · 2006not yet assessed
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Postsynaptic Shank Antagonizes Dendrite Branching Induced by the Leucine-Rich Repeat Protein Densin-180 ↗Journal of Neuroscience · 2005 · PMID 15647492not yet assessed
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Interactions with PDZ Domain Proteins PIST/GOPC and PDZK1 Regulate Intracellular Sorting of the Somatostatin Receptor Subtype 5 ↗Journal of Biological Chemistry · 2005 · PMID 16012170not yet assessed
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The PDZ/coiled‐coil domain containing protein PIST modulates insulin secretion in MIN6 insulinoma cells by interacting with somatostatin receptor subtype 5 ↗FEBS Letters · 2005 · PMID 16263117not yet assessed
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Differential β-Arrestin Trafficking and Endosomal Sorting of Somatostatin Receptor Subtypes ↗Journal of Biological Chemistry · 2004 · PMID 15001578not yet assessed
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Differential expression and dendritic transcript localization of Shank family members: identification of a dendritic targeting element in the 3′ untranslated region of Shank1 mRNA ↗Molecular and Cellular Neuroscience · 2004 · PMID 15121189not yet assessed
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Insulin receptor substrate of 53 kDa links postsynaptic shank to PSD‐95 ↗Journal of Neurochemistry · 2004 · PMID 15255944not yet assessed
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Characterization of Staufen 1 ribonucleoprotein complexes ↗Biochemical Journal · 2004 · PMID 15303970not yet assessed
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Functional correlates of somatostatin receptor 2 overexpression in the retina of mice with genetic deletion of somatostatin receptor 1 ↗Brain Research · 2004 · PMID 15464758not yet assessed
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Altered morphology of rod bipolar cell axonal terminals in the retinas of mice carrying genetic deletion of somatostatin subtype receptor 1 or 2 ↗European Journal of Neuroscience · 2004 · PMID 14750962not yet assessed
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Role of Amphiphysin II in Somatostatin Receptor Trafficking in Neuroendocrine Cells ↗Journal of Biological Chemistry · 2004 · PMID 14660576not yet assessed
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The magic of synaptogenesis ↗EMBO Reports · 2004 · PMID 15550929not yet assessed
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Role of the G-Protein-Coupled Receptor GPR12 as High-Affinity Receptor for Sphingosylphosphorylcholine and Its Expression and Function in Brain Development ↗Journal of Neuroscience · 2003 · PMID 12574419not yet assessed
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Sphingosine-1-phosphate is a high-affinity ligand for the G protein-coupled receptor GPR6 from mouse and induces intracellular Ca2+ release by activating the sphingosine-kinase pathway ↗Biochemical and Biophysical Research Communications · 2003 · PMID 14592418not yet assessed
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Genetic deletion of somatostatin receptor 1 alters somatostatinergic transmission in the mouse retina ↗Neuropharmacology · 2003 · PMID 14614951not yet assessed
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Functional Annotation of Two Orphan G-protein-coupled Receptors, Drostar1 and -2, from Drosophila melanogaster and Their Ligands by Reverse Pharmacology ↗Journal of Biological Chemistry · 2002 · PMID 12167655not yet assessed
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GPR99, a new G protein-coupled receptor with homology to a new subgroup of nucleotide receptors ↗BMC Genomics · 2002 · PMID 12098360not yet assessed
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Putative histamine‐gated chloride channel subunits of the insect visual system and thoracic ganglion ↗Journal of Neurochemistry · 2002 · PMID 12390512not yet assessed
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Interaction of G-protein-coupled receptors with synaptic scaffolding proteins ↗Biochemical Society Transactions · 2002 · PMID 12196116not yet assessed
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MIZIP, a highly conserved, vertebrate specific melanin‐concentrating hormone receptor 1 interacting zinc‐finger protein<sup>1</sup> ↗FEBS Letters · 2002 · PMID 12208518not yet assessed
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Homo- and Heterodimerization of Somatostatin Receptor Subtypes ↗Journal of Biological Chemistry · 2001 · PMID 11134004not yet assessed
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Synaptic Scaffolding Proteins in Rat Brain ↗Journal of Biological Chemistry · 2001 · PMID 11509555not yet assessed
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Structural, Functional, and Evolutionary Characterization of Novel Members of the Allatostatin Receptor Family from Insects ↗Biochemical and Biophysical Research Communications · 2001 · PMID 11352636not yet assessed
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The Calcium-independent Receptor for α-Latrotoxin from Human and Rodent Brains Interacts with Members of the ProSAP/SSTRIP/Shank Family of Multidomain Proteins ↗Journal of Biological Chemistry · 2000 · PMID 10964907not yet assessed
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Intracellular Dynamics of sst5 Receptors in Transfected COS-7 Cells: Maintenance of Cell Surface Receptors during Ligand-Induced Endocytosis1 ↗Endocrinology · 2000 · PMID 10614658not yet assessed
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Interaction of the Somatostatin Receptor Subtype 1 with the Human Homolog of the Shk1 Kinase-binding Protein from Yeast ↗Journal of Biological Chemistry · 2000 · PMID 10734105not yet assessed
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Identification of proteins interacting with the rat somatostatin receptor subtype 2 ↗Journal of Physiology-Paris · 2000 · PMID 11087996not yet assessed
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Identification of melanin concentrating hormone (MCH) as the natural ligand for the orphan somatostatin‐like receptor 1 (SLC‐1) ↗FEBS Letters · 1999 · PMID 10471841not yet assessed
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Somatostatin Receptor Interacting Protein Defines a Novel Family of Multidomain Proteins Present in Human and Rodent Brain ↗Journal of Biological Chemistry · 1999 · PMID 10551867not yet assessed
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Molecular Biology of the Receptors for Somatostatin and Cortistatin ↗Results and problems in cell differentiation · 1999 · PMID 10453466not yet assessed
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Agonist-dependent Interaction of the Rat Somatostatin Receptor Subtype 2 with Cortactin-binding Protein 1 ↗Journal of Biological Chemistry · 1999 · PMID 10373412not yet assessed
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Agonist‐Independent Internalization and Activity of a C‐Terminally Truncated Somatostatin Receptor Subtype 2(δ349) ↗Journal of Neurochemistry · 1999 · PMID 10037501not yet assessed
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Coupling of rat somatostatin receptor subtypes to a G‐protein gated inwardly rectifying potassium channel (GIRK1) ↗FEBS Letters · 1997 · PMID 9426226not yet assessed
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Phosphorylation of Four Amino Acid Residues in the Carboxyl Terminus of the Rat Somatostatin Receptor Subtype 3 Is Crucial for Its Desensitization and Internalization ↗Journal of Biological Chemistry · 1997 · PMID 9295322not yet assessed
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Opioid receptors from a lower vertebrate ( <i>Catostomus commersoni</i> ): Sequence, pharmacology, coupling to a G-protein-gated inward-rectifying potassium channel (GIRK1), and evolution ↗Proceedings of the National Academy of Sciences · 1997 · PMID 9223341not yet assessed
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Distinct Agonist‐Mediated Endocytosis of Cloned Rat Somatostatin Receptor Subtypes Expressed in Insulinoma Cells ↗Journal of Neuroendocrinology · 1997 · PMID 9355043not yet assessed
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Mutational analysis and molecular modeling of the nonapeptide hormone binding domains of the [Arg8]vasotocin receptor. ↗Proceedings of the National Academy of Sciences · 1996 · PMID 8692917not yet assessed
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Molecular dissection of subunit interfaces in the acetylcholine receptor: Identification of determinants of α-Conotoxin M1 selectivity ↗Neuron · 1995 · PMID 7619523not yet assessed
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Intersubunit contacts governing assembly of the mammalian nicotinic acetylcholine receptor ↗Neuron · 1995 · PMID 7695910not yet assessed
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Molecular Determinants Conferring α-Toxin Resistance in Recombinant DNA-derived Acetylcholine Receptors ↗Journal of Biological Chemistry · 1995 · PMID 7876169not yet assessed
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Conserved tyrosines in the alpha subunit of the nicotinic acetylcholine receptor stabilize quaternary ammonium groups of agonists and curariform antagonists. ↗Journal of Biological Chemistry · 1994 · PMID 8132615not yet assessed
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Glycosylation sites selectively interfere with alpha-toxin binding to the nicotinic acetylcholine receptor. ↗Journal of Biological Chemistry · 1994 · PMID 7907588not yet assessed
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Expression and ligand specificity of acetylcholinesterase and the nicotinic receptor: a tale of two cholinergic sites ↗Biochemical Society Transactions · 1994 · PMID 7821676not yet assessed
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Mapping the functional topography of a receptor. ↗PubMed · 1993 · PMID 1299215not yet assessed
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Investigation of ligand binding sites of the acetylcholine receptor using photoactivatable derivatives of neurotoxin II from Naja naja oxiana ↗Biochemistry · 1992 · PMID 1525162not yet assessed
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Sequence‐specific <sup>1</sup>H‐NMR assignment and determination of the secondary structure of bovine heart fatty‐acid‐binding protein ↗European Journal of Biochemistry · 1992 · PMID 1483473not yet assessed
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Anionic subsites of the catalytic center of acetylcholinesterase from Torpedo and from cobra venom. ↗Proceedings of the National Academy of Sciences · 1991 · PMID 2068091not yet assessed
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Anionic subsites of the acetylcholinesterase from Torpedo californica: affinity labelling with the cationic reagent N,N‐dimethyl‐2‐phenyl‐aziridinium. ↗The EMBO Journal · 1990 · PMID 2249655not yet assessed
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The active site and partial sequence of cobra venom acetylcholinesterase ↗Journal of Protein Chemistry · 1990 · PMID 2340076not yet assessed
Full bibliography from OpenAlex; reproducibility verdicts matched by PMID.
Author attribution follows OpenAlex disambiguation, which is imperfect — a researcher's papers can be split across profiles or mixed with a namesake.
Merged across profiles sharing this ORCID where present. See every “Kreienkamp H” paper on PubMed ↗