Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Integrating human plasma proteomes with genome-wide association data implicates novel proteins and drug targets for rheumatoid arthritis.

  PMID 41540382 · PMC12892679 · Clinical proteomics · 2026 · 8 claims · 8 setups

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  PWAS integrating RA GWAS with ARIC and INTERVAL plasma pQTL data identified 35 genetically regulated proteins (42 associations) significantly associated with RA risk.

  plasma shared gtex blood proteome-wide two-sample bayesian

• Spatial single-cell multiomics reveals peripheral immune dysfunction in Parkinson's and inflammatory bowel disease.

  PMID 41545356 · PMC12847817 · NPJ Parkinson's disease · 2026 · 8 claims · 5 setups

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  Spatial single-cell multiomic imaging of sigmoid colon reveals both shared and unique features of peripheral immune dysfunction in PD and IBD

  sigmoid plasma stool epithelial cosmx meso gene

• Radiogenomics predicts immune microenvironment heterogeneity and response to combination immunotherapy in hepatocellular carcinoma.

  PMID 41555384 · PMC12895822 · Journal of translational medicine · 2026 · 8 claims · 8 setups

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  A parsimonious 2-gene immune-related signature (IRS = 0.425×KPNA2 + 0.302×SMG5) is significantly associated with immune heterogeneity and response to ICI plus anti-angiogenic combination therapy in HCC

  hcc gse202642 paired hcc-derived bulk single-cell immunohistochemistry

• Cellular insights into transposable elements in Alzheimer's disease.

  PMID 41573740 · PMC12819740 · Frontiers in molecular biosciences · 2025 · 8 claims · 5 setups

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  508 TE loci are differentially expressed in AD brain, with the large majority (84.3%) upregulated, indicating widespread TE activation

  postmortem brain genome genes single-nucleus atac-seq pseudobulk

• Spatial gene expression analysis reveals drivers of extremely early lymph node metastasis in breast cancer.

  PMID 41578129 · PMC12932634 · NPJ breast cancer · 2026 · 8 claims · 7 setups

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  Identified 30 isolated tumor cells (ITCs) in a clinically metastasis-negative tumor-draining lymph node, representing the initial metastatic seeding event, spanning ~200 μm

  dissected same tumor xenium-derived bulk enzymatic whole-genome

• Genetics and environment distinctively shape the human immune cell epigenome.

  PMID 41593234 · PMC12900638 · Nature genetics · 2026 · 8 claims · 6 setups

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  Exposure-associated differentially methylated regions (eDMRs) and genotype-associated DMRs (gDMRs) show distinct genomic distributions: eDMRs are enriched at enhancers/regulatory regions, while gDMRs are predominantly found in gene bodies.

  pbmcs pbmc edmrs differentially single-nucleus fluorescence-activated motif

• Protocadherin 20 Is a POU Class 2 Homeobox 3 Target Gene Required for Proper Tuft Cell Microvillus Organization.

  PMID 41619969 · PMC13051935 · Cellular and molecular gastroenterology and hepatology · 2026 · 8 claims · 8 setups

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  POU2F3 ChIP-seq in isolated murine tuft cells identifies high-confidence POU2F3 binding sites/target genes enriched at gene promoters and the POU consensus motif

  facs-isolated pou2f3 duodenal non-small-cell chip-seq novo bulk

• FLASH-MM: fast and scalable single-cell differential expression analysis using linear mixed-effects models.

  PMID 41644528 · PMC12982622 · Nature communications · 2026 · 8 claims · 6 setups

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  FLASH-MM produces LMM parameter estimates identical to lmer (lme4) up to the sixth decimal place while being 50- to 140-fold faster as sample size increases from 20,000 to 120,000 cells

  simulated same healthy female-biased simulated comparative single-cell

• Epigenetic profiling of hematopoietic stem cells from male mice identifies KDR and PU.1 as regulators of aging transcriptome and caloric restriction response.

  PMID 41720793 · PMC13035812 · Nature communications · 2026 · 8 claims · 8 setups

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  Lifelong CR reduces white blood cell production and shifts hematopoiesis toward myeloid and thrombo-erythroid lineages while suppressing lymphoid output

  peripheral sorted young aged complete flow bulk

• Reconstruction of the lifeways of Central European Late Bronze Age communities using ancient DNA, isotope and osteoarchaeological analyses.

  PMID 41735297 · PMC12932679 · Nature communications · 2026 · 7 claims · 8 setups

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  Late Bronze Age individuals from Central Germany (Kuckenburg/Esperstedt) show genetic continuity with the preceding Early Bronze Age Únětice population.

  skeletal ancient newly shotgun principal admixture

• Benchmarking LLM-based agents for single-cell omics analysis.

  PMID 41742311 · PMC13064268 · Genome biology · 2026 · 8 claims · 8 setups

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  Introduces a comprehensive benchmarking evaluation system comprising an open-source agent platform, 18 evaluation metrics across four dimensions, and 50 real-world single-cell omics tasks

  agent single-cell spatial scatac-seq llm-agent scrna-seq spatial

• Long-read sequencing and proteomics reveal blood transcriptome and protein expression profiles in multiple primary lung cancers.

  PMID 41761147 · PMC13059216 · BMC cancer · 2026 · 6 claims · 7 setups

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  MPC patients exhibit significantly increased blood transcript complexity, with higher numbers of DEGs, DETs, and DTU events than OPLC and HC groups

  blood serum degs ont dia differential

• Single-cell RNA sequencing of adenoid cystic carcinoma of the breast reveals cellular heterogeneity and tumor microenvironment features.

  PMID 41761191 · PMC13041279 · BMC medical genomics · 2026 · 8 claims · 7 setups

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  H19+ myoepithelial cells (H19+myoEpC) represent the dominant malignant subpopulation in ACCB, characterized by the majority of large-scale CNVs and high expression of oncogenic pathway genes and ligands (e.g., LAMB1, WNT6)

  tumor hnacc epithelial accb single-cell scrna-seq copy

• Functional genomics analysis of developing zebrafish and human endoderm reveals highly conserved cis-regulatory modules acting during vertebrate organogenesis.

  PMID 41781333 · PMC7619044 · Genome research · 2026 · 8 claims · 8 setups

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  There are few endoderm-specific CRMs; many CRMs governing pancreas development also likely act within the nervous system

  zebrafish embryonic atac-seq bulk facs

• Uncovering the transcriptional landscape of estrogen-induced gonadal feminization in the Chinese giant salamander.

  PMID 41808025 · PMC13085422 · BMC genomics · 2026 · 8 claims · 7 setups

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  E2 exposure induces male-to-female gonadal sex reversal in CGS, confirmed by histological evidence across developmental stages.

  gonadal tail-tip deg candidate rna-seq histology rt-qpcr

• De novo assembly of a transcriptome for Calanus finmarchicus (Crustacea, Copepoda)--the dominant zooplankter of the North Atlantic Ocean.

  PMID 24586345 · PMC3929608 · PloS one · 2014 · 8 claims · 8 setups

  Has reproduction · 59

  A de novo transcriptome for Calanus finmarchicus was assembled from six developmental-stage libraries, yielding 206,041 contigs and a reference set of 96,090 unique comps, representing a new molecular resource for this species.

  calanus pooled raw combined bulk extraction read

• Insights into karyotype evolution and flower color variation from the genome assembly of wallflower (Erysimum cheiri).

  PMID 41824659 · PMC13089509 · Plant physiology · 2026 · 7 claims · 8 setups

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  A near-complete telomere-to-telomere genome assembly of E. cheiri was generated (244.33 Mb, 6 chromosomes)

  cheiri brassicaceae illumina pacbio hi-c

• Insights from pooled CRISPRi single-cell screens in K562 cells reveal gene functions, regulatory networks, and highlight opportunities and limitations.

  PMID 41826830 · PMC13097927 · BMC genomics · 2026 · 7 claims · 7 setups

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  A modified CROP-seq-CRISPRi protocol allows direct capture of sgRNAs from the cDNA library without a separate enrichment step, improving sgRNA assignment per cell

  k562 lentiviral pooled plasmid amplicon

• Exploring the mechanism of action of abemaciclib in breast cancer through circulating chromatin fragments.

  PMID 41845059 · PMC13149665 · Communications medicine · 2026 · 8 claims · 5 setups

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  cfDNA concentrations are significantly higher in breast cancer patients than healthy donors and decline following abemaciclib therapy

  serum t47d edger-normalized cfdna proliferation pathway

• Interpretable learning of temporal cellular dynamics from single-cell data.

  PMID 41875867 · PMC13030976 · Cell reports methods · 2026 · 7 claims · 7 setups

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  NeuroVelo couples a linear latent phase-space projection with a non-linear neural ODE, using RNA velocity as a physics-informed loss penalty, to jointly model cellular dynamics and enable gene-level interpretability

  gastrulation bone pancreatic cancer scrna-seq chip-seq computational