Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

Publications 1.3k Datasets 392.5k Experiments 17

Assay: colony-forming ✕ Clear

Regulatory and evolutionary adaptation of yeast to acute lethal ethanol stress.

PMID 33170850 · PMC7654773 · PloS one · 2020 · 8 claims · 4 setups

Has reproduction · 68

Yeast cells activate a rapid transcriptional reprogramming process following acute lethal ethanol stress that is likely adaptive for post-stress survival

haploid pooled colony bulk pooled
Triplex targeted genomic crosslinks enter separable deletion and base substitution pathways.

PMID 16186129 · PMC1236719 · Nucleic acids research · 2005 · 8 claims · 4 setups

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Targeted pso-TFO genomic crosslinks resolve via genetically separable pathways leading to either base substitutions or deletions.

cho same uv41 6-tg small sequencing
Bacteriophage Mu integration in yeast and mammalian genomes.

PMID 18953026 · PMC2602771 · Nucleic acids research · 2008 · 8 claims · 8 setups

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In vitro-assembled Mu transpososomes, delivered by electroporation, efficiently integrate marker genes into yeast, mouse ES, human HeLa, and human ES cell genomes

cerevisiae ab2.2 hela fes29 electroporation southern transposition
Transcriptomic Adjustments of Staphylococcus aureus COL (MRSA) Forming Biofilms Under Acidic and Alkaline Conditions.

PMID 31681245 · PMC6813237 · Frontiers in microbiology · 2019 · 5 claims · 5 setups

Has reproduction · 73

S. aureus COL (MRSA) survives and grows well under acidic (pH5) and alkaline (pH9) conditions, both planktonically and as a biofilm

aureus microarray colony extraction
Endothelial stem cells of the retinal vasculature reside in the optic nerve.

PMID 41577708 · PMC12830651 · Nature communications · 2026 · 8 claims · 8 setups

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CD157+CD201+ endothelial stem cells (VESCs) reside predominantly in the optic nerve and supply endothelial cells to the retina

cd45negcd31+ sorted retina procr[cd201]-creert2 flow colony-forming flat-mount
comBO: A combined human bone and lympho-myeloid bone marrow organoid for preclinical modeling of hematopoietic disorders.

PMID 41734765 · PMC7618947 · Cell stem cell · 2026 · 8 claims · 8 setups

Has reproduction · 65

comBO is a single iPSC-derived organoid differentiation that generates osteolineage, vascular, lymphoid, and myeloid compartments together

hipsc-derived combo combo-derived healthy-donor flow single-cell confocal
Vascular adhesion protein-1 defines a unique subpopulation of human hematopoietic stem cells and regulates their proliferation.

PMID 34719737 · PMC8629906 · Cellular and molecular life sciences : CMLS · 2021 · 7 claims · 8 setups

Has reproduction · 50

VAP-1 is expressed on a subset of human HSC and on bone marrow vasculature forming a hematogenic niche

bone sorted cord femur flow bulk single-cell
Bioengineering a humanized acne microenvironment model: proteomics analysis of host responses to Propionibacterium acnes infection in vivo.

PMID 18651708 · PMC2699546 · Proteomics · 2008 · 8 claims · 6 setups

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A dermis-based cell-trapped system (DBCTS) with human sebocytes inserted into a subcutaneous tissue chamber creates a humanized acne microenvironment in mice

chamber infiltrated de-epidermized sebocyte cfu sandwich immunofluorescence
Technical challenges in using human induced pluripotent stem cells to model disease.

PMID 19951687 · PMC2921621 · Cell stem cell · 2009 · 8 claims · 8 setups

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hiPSCs generated from patient somatic cells (skin, blood) can be differentiated into disease-relevant cell types to model disease pathogenesis in vitro

ipscs humanized hemophilia parkinsonian tetraploid transplantation neuronal
Somatic mutations of the Parkinson's disease-associated gene PARK2 in glioblastoma and other human malignancies.

PMID 19946270 · PMC4002225 · Nature genetics · 2010 · 8 claims · 8 setups

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PARK2 is a frequently and specifically targeted gene within recurrent 6q25.2-q27 copy number losses in glioblastoma and colon cancer

colon gbm cancer dbtrg array pcr colony
Double-strand breaks in the myotonic dystrophy type 1 and the fragile X syndrome triplet repeat sequences induce different types of mutations in DNA flanking sequences in Escherichia coli.

PMID 17012280 · PMC1636463 · Nucleic acids research · 2006 · 7 claims · 5 setups

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DSBs induced at the TRS/vector junction (EcoRV site) generate numerous mutagenic events in flanking sequences, whereas DSBs within the repeat tract (EcoRI site) produce no such mutants

coli plasmids plasmid white plasmid sequencing non-b
MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia.

PMID 16834459 · PMC1502153 · PLoS medicine · 2006 · 8 claims · 8 setups

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A somatic activating mutation in MPL (W515L, transmembrane domain) is present in 9% (4/45) of JAK2V617F-negative myelofibrosis (MF) patients

granulocyte hapmap 32d balb sequencing genotyping proliferation
Lysine 63-polyubiquitination guards against translesion synthesis-induced mutations.

PMID 16789823 · PMC1513265 · PLoS genetics · 2006 · 8 claims · 8 setups

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K63-polyubiquitin chain formation protects human cells against translesion synthesis-induced mutations by promoting error-free recovery of blocked replication forks.

a549 western proliferation clonogenic
Phenotypic screening, transcriptional profiling, and comparative genomic analysis of an invasive and non-invasive strain of Candida albicans.

PMID 18950481 · PMC2579918 · BMC microbiology · 2008 · 8 claims · 8 setups

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Strain SC5314 is invasive and virulent whereas strain ATCC10231 is non-invasive and strongly attenuated in virulence

albicans hep-2 rhe blood phenotypic growth adhesion
RANKL inhibits macrophage proinflammatory Toll-like receptor 2 and 4 signaling and impairs killing of intracellular bacteria.

PMID 42177796 · PMC13198865 · ImmunoHorizons · 2026 · 8 claims · 8 setups

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Prior RANKL exposure increases intracellular Salmonella Typhimurium (STm) burden in mouse and human macrophages

bone bmdms raw-dual splenic bacterial viability sequencing
Uropathogenic Escherichia coli invade luminal prostate cells via FimH-PPAP receptor binding.

PMID 41507584 · PMC12872464 · Nature microbiology · 2026 · 8 claims · 8 setups

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A 2D mouse stem cell-derived prostate epithelial organoid model was developed that mimics epithelial heterogeneity of the murine prostate

prostate bladder immunofluorescence single-cell transepithelial
Gut-derived Lactobacillus from exceptional responders mitigates chemoradiotherapy-induced intestinal injury through methionine-driven epigenetic modulation.

PMID 40469520 · PMC12130557 · iMeta · 2025 · 8 claims · 8 setups

Has reproduction · 89

High pretreatment abundance of Lactobacillus (and Bifidobacterium) in gut microbiota correlates with absence of ACRIII in rectal cancer patients

fecal bacterial whole-abdomen cecal metagenomic random fecal

Experiments

Regulatory and evolutionary adaptation of yeast to acute lethal ethanol stress.

Triplex targeted genomic crosslinks enter separable deletion and base substitution pathways.

Bacteriophage Mu integration in yeast and mammalian genomes.

Transcriptomic Adjustments of Staphylococcus aureus COL (MRSA) Forming Biofilms Under Acidic and Alkaline Conditions.

Endothelial stem cells of the retinal vasculature reside in the optic nerve.

comBO: A combined human bone and lympho-myeloid bone marrow organoid for preclinical modeling of hematopoietic disorders.

Vascular adhesion protein-1 defines a unique subpopulation of human hematopoietic stem cells and regulates their proliferation.

Bioengineering a humanized acne microenvironment model: proteomics analysis of host responses to Propionibacterium acnes infection in vivo.

Technical challenges in using human induced pluripotent stem cells to model disease.

Somatic mutations of the Parkinson's disease-associated gene PARK2 in glioblastoma and other human malignancies.

Double-strand breaks in the myotonic dystrophy type 1 and the fragile X syndrome triplet repeat sequences induce different types of mutations in DNA flanking sequences in Escherichia coli.

MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia.

Lysine 63-polyubiquitination guards against translesion synthesis-induced mutations.

Phenotypic screening, transcriptional profiling, and comparative genomic analysis of an invasive and non-invasive strain of Candida albicans.

RANKL inhibits macrophage proinflammatory Toll-like receptor 2 and 4 signaling and impairs killing of intracellular bacteria.

Uropathogenic Escherichia coli invade luminal prostate cells via FimH-PPAP receptor binding.

Gut-derived Lactobacillus from exceptional responders mitigates chemoradiotherapy-induced intestinal injury through methionine-driven epigenetic modulation.