Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• A lack of parasitic reduction in the obligate parasitic green alga Helicosporidium.

  PMID 24809511 · PMC4014436 · PLoS genetics · 2014 · 8 claims · 8 setups

  Has reproduction · 30

  The Helicosporidium nuclear genome is small and compact (~2.5-fold smaller than Chlorella and Coccomyxa) yet shows almost no evidence of functional/metabolic reduction.

  helicosporidium ten whole-genome transcriptome gene

• Endothelial stem cells of the retinal vasculature reside in the optic nerve.

  PMID 41577708 · PMC12830651 · Nature communications · 2026 · 8 claims · 8 setups

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  CD157+CD201+ endothelial stem cells (VESCs) reside predominantly in the optic nerve and supply endothelial cells to the retina

  cd45negcd31+ sorted retina procr[cd201]-creert2 flow colony-forming flat-mount

• Humoral IgG1 responses to tumor antigens underpin clinical outcomes in immune checkpoint blockade.

  PMID 41593194 · PMC13004670 · Nature medicine · 2026 · 8 claims · 5 setups

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  PD-1 blockade induces tumor-specific IgG1+ plasma cell responses that complement cellular immunity and contribute to clinical benefit

  tumor paired single-cell bulk multiplex

• Oxidative stress-associated genes TPPP3 and VEGFA in COPD revealed by bulk and single-cell sequencing analysis.

  PMID 41620539 · PMC12916760 · Scientific reports · 2026 · 8 claims · 9 setups

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  76 overlapping genes were identified between COPD-associated DEGs and oxidative stress-related genes.

  lung genecards differentially bronchial bulk database functional

• PolyAseqTrap: a universal tool for genome-wide identification and quantification of polyadenylation sites from different 3' end sequencing data.

  PMID 41620776 · PMC12947541 · Genome biology · 2026 · 6 claims · 7 setups

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  PolyAseqTrap is a universal R package for identifying and quantifying polyA sites from diverse 3' end sequencing data

  species arabidopsis seq polyasite end direct deep

• Evolutionary Dynamics of Dosage Compensation and Sex-biased Gene Expression in Morabine Grasshopper Vandiemenella viatica.

  PMID 41635935 · PMC12930189 · Genome biology and evolution · 2026 · 8 claims · 6 setups

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  Somatic tissues (heads, legs) show near-complete dosage compensation, with male X-linked (P24X0) and XL-linked (P24XY) genes upregulated to match female and autosomal expression levels.

  p24x0 p24xy rna-seq comparative differential

• Microbiota-derived IPA protects against colitis by regulating intestinal HMGCS2-mediated ketogenesis to facilitate mucosal healing.

  PMID 41651833 · PMC12988232 · Nature communications · 2026 · 8 claims · 8 setups

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  IPA is consistently depleted in IBD/colitis patients and in murine colitis models relative to healthy controls

  fecal c57bl germ-free mice quasi-targeted dss-induced tnbs-induced

• pmid-41680182

  PMID 41680182 · PMC13009336 · 8 claims · 7 setups

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  Early-phase macrophage depletion (MaFIA + AP20187) reduces fibrosis/scar area and mesenchymal cell numbers without delaying reepithelialization or angiogenesis.

  mafia nih pdgfra-rtta flow excisional immunofluorescence

• Synaptic dysfunction and oxidative stress in Alzheimer's disease: emerging mechanisms.

  PMID 16989739 · PMC3933161 · Journal of cellular and molecular medicine · 2006 · 6 claims · 8 setups

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  Mutations in APP, PS1 and PS2 genes and polymorphisms in the APOE gene are implicated in AD pathogenesis

  alzheimer brain alzheimer's presenilin-1 microarray proteomic transgenic

• Preparation of mouse pancreatic tumor for single-cell RNA sequencing and analysis of the data.

  PMID 34927097 · PMC8649395 · STAR protocols · 2021 · 6 claims · 7 setups

  Has reproduction · 50

  A combined mechanical and enzymatic dissociation protocol using the gentleMACS Dissociator yields a single-cell suspension from mouse pancreatic tumor tissue suitable for scRNA-seq while preserving cell characteristics

  pancreatic dissociated single-cell scrna-seq tumor dead red

• High-throughput sequencing SELEX for the determination of DNA-binding protein specificities in vitro.

  PMID 35776646 · PMC9243297 · STAR protocols · 2022 · 8 claims · 8 setups

  Has reproduction · 65

  HT-SELEX enables unbiased, in vitro determination of preferred DNA target motifs for DNA-binding proteins by iterative selection and PCR amplification of bound oligonucleotides

  synthetic pcr-generated selex histidine-tagged pcr polyacrylamide spectrophotometry

• Advances in the study of SR protein family.

  PMID 15626328 · PMC5172405 · Genomics, proteomics & bioinformatics · 2003 · 8 claims · 8 setups

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  SR proteins promote assembly of the early splicesome via protein-protein interactions in their RS-domain that recruit components of the splicing machinery.

  nuclear bovine drosophila caenorhabditis selex rna-binding splicing

• The genome sequence of the Gold Spangle, Autographa bractea (Denis & Schiffermüller), 1775 (Lepidoptera: Noctuidae).

  PMID 41710118 · PMC12910202 · Wellcome open research · 2026 · 8 claims · 8 setups

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  A chromosome-level, haplotype-resolved genome assembly was produced for Autographa bractea (Gold Spangle)

  autographa pacbio hi-c k-mer

• The genome sequence of the Provence Hairstreak, Tomares ballus (Fabricius, 1787) (Lepidoptera: Lycaenidae).

  PMID 41710119 · PMC12910201 · Wellcome open research · 2026 · 7 claims · 8 setups

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  A genome assembly was produced for a male Tomares ballus specimen consisting of two haplotypes (839.94 Mb and 831.10 Mb)

  organism pacbio assembled pacbio hi-c k-mer

• The genome sequence of the Spanish Festoon, Zerynthia rumina (Linnaeus, 1758) (Lepidoptera: Papilionidae).

  PMID 41769331 · PMC12946699 · Wellcome open research · 2026 · 8 claims · 7 setups

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  A genome assembly for Zerynthia rumina was produced, containing two haplotypes of 852.84 Mb and 775.60 Mb

  organism genomic assembled haplotype pacbio hi-c k-mer

• The genome sequence of the Carline Skipper, Pyrgus carlinae (Rambur, 1839) (Lepidoptera: Hesperiidae).

  PMID 41841042 · PMC12989058 · Wellcome open research · 2026 · 8 claims · 8 setups

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  A chromosome-level genome assembly was generated for a female Pyrgus carlinae specimen (ilPyrCarl1) as part of Project Psyche

  pyrgus pacbio hi-c k-mer

• The genome sequence of the Bicolour Sedge, Triaenodes bicolor (Curtis, 1834) (Trichoptera: Leptoceridae).

  PMID 41852352 · PMC12993304 · Wellcome open research · 2026 · 7 claims · 8 setups

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  A genome assembly was generated for a male Triaenodes bicolor specimen, comprising two haplotypes of 615.75 Mb and 613.86 Mb.

  triaenodes pacbio hi-c barcoding

• The genome sequence of the Oriental Meadow Brown, Cercyonis lupina (Lepidoptera: Nymphalidae).

  PMID 41924386 · PMC13036442 · Wellcome open research · 2026 · 8 claims · 8 setups

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  Genome of Cercyonis lupina assembled into two haplotypes with total lengths of 508.65 Mb (haplotype 1) and 467.75 Mb (haplotype 2)

  organism pacbio assembled scaffolded pacbio hi-c k-mer

• The genome sequence of the Golden Plusia, Polychrysia moneta (Fabricius, 1787) (Lepidoptera: Noctuidae).

  PMID 41938267 · PMC13047365 · Wellcome open research · 2026 · 8 claims · 8 setups

  Full-text index only

  A chromosome-level genome assembly was produced for a male Polychrysia moneta specimen as part of Project Psyche.

  moneta assembled haplotype pacbio hi-c k-mer

• The genome sequence of the Sage Skipper, Muschampia proto (Ochsenheimer, 1808) (Lepidoptera: Hesperiidae).

  PMID 41938270 · PMC13049433 · Wellcome open research · 2026 · 8 claims · 8 setups

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  A chromosome-level genome assembly was produced for Muschampia proto, with 99.67% of haplotype 1 scaffolded into 30 chromosomal pseudomolecules including the Z sex chromosome.

  organism pacbio hifi assembled pacbio hi-c k-mer