Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Single-nucleus multiome analysis in the human prefrontal cortex identifies gene expression and cis-regulatory elements associated with aging.

  PMID 41832957 · PMC13137218 · Cell reports · 2026 · 8 claims · 8 setups

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  Generated a single-nucleus multiome (snATAC + gene expression) dataset from 357 human dorsolateral prefrontal cortex samples (ages 15-100, European and African admixed ancestry), yielding over 1.5 million cells as a public resource.

  postmortem million+ pfc each single-nucleus umap pseudobulk

• Out-of-frame CBX3::ALK fusion drives ALK activation and therapy response.

  PMID 41887222 · PMC13130619 · Cell reports. Medicine · 2026 · 8 claims · 8 setups

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  A CBX3::ALK out-of-frame fusion was identified in a patient with metastatic melanoma

  metastatic cutaneous tumor hek293t targeted immunohistochemistry fluorescence

• Enhanced IFNy response in dedifferentiated melanoma cells is due to chromatin remodeling as revealed by ATAC-seq.

  PMID 41904529 · PMC13217986 · Cell communication and signaling : CCS · 2026 · 8 claims · 7 setups

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  MITF knockdown and IFNγ stimulation each produce substantial but distinct changes in chromatin accessibility in 624Mel melanoma cells

  624mel melanoma atac-seq western motif

• MiR-21-5p Protects Embryonic Growth and Heart Function During Developmental Hypoxia by Dampening HIF Responses and Altering Gene Expression.

  PMID 42138560 · PMC13178401 · Comprehensive Physiology · 2026 · 8 claims · 7 setups

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  Hypoxia induces widespread transcriptomic remodeling in neonatal rat cardiomyocytes (385 DEGs vs normoxia)

  neonatal chicken fetal tunel long-read exon-level

• Characterizing Response to PARP Inhibitor Treatment Combinations in Advanced Prostate Cancer.

  PMID 42193276 · PMC13203762 · Biomedicines · 2026 · 8 claims · 8 setups

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  PARPi + ARPi combinations are effective in ARPi-sensitive (C4-2B) and ARPi-resistant (AbiR, MDVR) prostate cancer models, but provide the greatest benefit in ARPi-sensitive cells

  c4-2b cck-8 morphology western

• Integrative sRNA, DNA Methylation, and Transcriptomics Reveals Dynamic Epigenetic Reprogramming of Meloidogyne javanica-Induced Galls in Arabidopsis.

  PMID 42196344 · PMC13207400 · International journal of molecular sciences · 2026 · 8 claims · 5 setups

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  Enrichment of 24 nt sRNAs (rasiRNAs) is a conserved hallmark of galls across early and late infection stages

  meloidogyne arabidopsis javanica-induced small rasirna chromosomal

• OTMODE: an optimal transport theory-based framework for identifying differential features in single-cell multi-omics data.

  PMID 41335419 · PMC12766913 · Bioinformatics (Oxford, England) · 2026 · 8 claims · 8 setups

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  OTMODE, using an unbalanced Sinkhorn algorithm and Wald test, improves differential feature identification in single-cell multi-omics data

  simulated classical degs naive simulated bulk real

• Longitudinal Profiling of Tumor and Immune Compartments Uncovers Patterns of Dysregulation and Associations with Response in Multiple Myeloma.

  PMID 41364805 · PMC13012255 · Blood cancer discovery · 2026 · 7 claims · 8 setups

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  IFN-γ signaling after autologous stem cell transplant (ASCT) is associated with markers of impaired CD8+ T-cell memory phenotype

  cd138neg cd138pos bone cd8+ single-cell bulk whole-genome

• Effector gene silencing coordinated by histone methylation and small RNAs enhances host adaptation in a plant pathogen.

  PMID 41505097 · PMC12781887 · Nucleic acids research · 2026 · 8 claims · 8 setups

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  CRISPR/Cas9 editing of PsSu(z)12 abolishes H3K27me3 deposition at Avr1b and Avr3a, causing transcriptional reactivation and loss of avirulence

  sojae soybean crispr homology-directed virulence

• Clonal CD8(+) T cells populate the leptomeninges and coordinate with immune cells in human degenerative brain diseases.

  PMID 41593242 · PMC12864034 · Nature immunology · 2026 · 8 claims · 6 setups

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  The human leptomeninges harbor substantial numbers of clonally expanded, tissue-resident memory CD8 T cells (ZNF683-high, CXCR6+, PD-1+)

  postmortem leptomeninges scrna-seq-derived leptomeningeal single-cell flow imaging

• Unveiling the early defense response dynamics in grapevines against Plasmopara viticola by single-cell transcriptomics.

  PMID 41593733 · PMC12918531 · Genome biology · 2026 · 8 claims · 5 setups

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  Generated the first single-cell transcriptome atlas (scRNA-seq + spRNA-seq) of grapevine leaves during P. viticola infection across four early time points (0, 3, 6, 12 hpi)

  vitis guard cabernet tissue-specific single-cell spatial pseudo-time

• ArGD: An Integrated Database and Analysis Platform for Artocarpus Genomics and Transcriptomics.

  PMID 41595510 · PMC12840728 · Genes · 2026 · 7 claims · 6 setups

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  ArGD is the first publicly accessible platform centrally integrating genomic data for the genus Artocarpus

  seven artocarpus five user-submitted functional bulk differential

• Multi-omics profiling reveals microenvironmental remodeling as a key driver of house dust mite-induced lung cancer progression.

  PMID 41610471 · PMC12874334 · Neoplasia (New York, N.Y.) · 2026 · 8 claims · 7 setups

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  Chronic HDM exposure accelerates lung tumor growth through non-mutagenic, immune-mediated mechanisms

  orthotopic lung beas-2b tumor bioluminescence h&e viability

• DHODH links mitochondrial bioenergetics, one-carbon metabolism, and DNA repair to sustain aggressive prostate adenocarcinoma.

  PMID 41612476 · PMC12930642 · Cell communication and signaling : CCS · 2026 · 8 claims · 8 setups

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  DHODH is markedly overexpressed in malignant prostate epithelial cells and abundant in tumors

  tcga-prad gse141445 22rv1 bulk single-cell lentiviral

• Tumour-brain crosstalk restrains cancer immunity via a sensory-sympathetic axis.

  PMID 41639447 · PMC12935554 · Nature · 2026 · 8 claims · 8 setups

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  Lung adenocarcinoma (LUAD) induces increased innervation and functional/transcriptional engagement of vagal sensory neurons (VSNs)

  kras-g12d tumour-bearing vagal npy2r-ires-cre whole-mount aav neurite

• An NSP2-MYB module orchestrates flavonoid biosynthesis and nodule symbiosis.

  PMID 41643674 · PMC7619063 · Current biology : CB · 2026 · 8 claims · 8 setups

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  NSP1 and NSP2 promote expression of flavonoid biosynthesis genes during nutrient starvation and rhizobial symbiosis in Medicago truncatula

  medicago nicotiana recombinant yeast rna-seq qpcr targeted

• Maternal Fine Particulate Matter Exposure Impairs Inguinal White Adipose Tissue Plasticity in Middle-Aged Male Mouse Offspring.

  PMID 41648986 · PMC12918713 · ACS nano · 2026 · 7 claims · 8 setups

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  Maternal PM2.5 exposure induces insulin resistance in middle-aged male (but not female) offspring despite normal body weight/obesity status

  pregnant iwat adsc whole-body body histology

• Microbiota-derived IPA protects against colitis by regulating intestinal HMGCS2-mediated ketogenesis to facilitate mucosal healing.

  PMID 41651833 · PMC12988232 · Nature communications · 2026 · 8 claims · 8 setups

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  IPA is consistently depleted in IBD/colitis patients and in murine colitis models relative to healthy controls

  fecal c57bl germ-free mice quasi-targeted dss-induced tnbs-induced

• Multi-omics analysis of somatic mutants reveals TCP7 allelically regulates multiple carotenogenic genes in citrus.

  PMID 41664139 · PMC12888363 · Molecular horticulture · 2026 · 7 claims · 7 setups

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  Red-fleshed and orange-fleshed Guanxi pomelo arose from two independent somatic mutation events from the same white-fleshed wild type

  pomelo wild-type rt-qpcr carotenoid genome

• Single-Cell RNA-Seq Profiling of Transposable Element Expression in Human Peripheral Blood Cells During Viral Infections.

  PMID 41683713 · PMC12898442 · International journal of molecular sciences · 2026 · 8 claims · 8 setups

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  TE expression is significantly higher in PBMCs from viral infection cohorts (and recovered individuals) compared to healthy controls

  pbmcs pbmc cd8+ single-cell cell-type expression