Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Sex-Based Differences in Cell Types and Gene Expression within the Anterior Cruciate Ligament.

  PMID 41587266 · PMC13011956 · The Journal of bone and joint surgery. American volume · 2026 · 8 claims · 5 setups

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  ACL tissue is heterogeneous, containing 5 major cell types: fibroblasts, pericytes, endothelial cells, macrophages, and T cells.

  acl differentially study flow single-cell immunofluorescence

• Evolutionary Dynamics of Dosage Compensation and Sex-biased Gene Expression in Morabine Grasshopper Vandiemenella viatica.

  PMID 41635935 · PMC12930189 · Genome biology and evolution · 2026 · 8 claims · 6 setups

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  Somatic tissues (heads, legs) show near-complete dosage compensation, with male X-linked (P24X0) and XL-linked (P24XY) genes upregulated to match female and autosomal expression levels.

  p24x0 p24xy rna-seq comparative differential

• Integrative microRNA and transcriptome analysis reveals sex-specific molecular divergence in human bladder cancer.

  PMID 41578372 · PMC12911049 · Biology of sex differences · 2026 · 8 claims · 8 setups

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  48 tumor-specific sex-biased (TSSB) microRNAs were identified in bladder cancer, mostly located on autosomes rather than sex chromosomes

  tcga tssb blca mirna-seq bulk kegg

• Analysis of the genome of the New Zealand giant collembolan (Holacanthella duospinosa) sheds light on hexapod evolution.

  PMID 29041914 · PMC5644144 · BMC genomics · 2017 · 8 claims · 8 setups

  Has reproduction · 72

  Phylogenomic analysis (370,877 amino acids) placed H. duospinosa within the family Neanuridae

  holacanthella duospinosa genome transcriptome phylogenomics

• TransOrGAN: An Artificial Intelligence Mapping of Rat Transcriptomic Profiles between Organs, Ages, and Sexes.

  PMID 37200521 · PMC10433534 · Chemical research in toxicology · 2023 · 8 claims · 5 setups

  Has reproduction · 84

  TransOrGAN can infer transcriptomic profiles between any 2 of 9 rat organs with an average cosine similarity of 0.984 versus real profiles

  fischer computational transcriptomic same bulk gan-based autoencoder

• COVID-19 vaccination atlas using an integrative systems vaccinology approach.

  PMID 40456760 · PMC12130191 · NPJ vaccines · 2025 · 8 claims · 6 setups

  Has reproduction · 69

  mRNA vaccines induce transient but strong immune responses after booster doses

  pbmcs immune pbmc bulk gene principal

• The emergence of multiple testicular cell lineages in human stem cell-derived testis-like organoids.

  PMID 41725354 · PMC12989076 · Development (Cambridge, England) · 2026 · 7 claims · 5 setups

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  hiPSC-derived testis-like organoids show significant transcriptional shifts from pluripotency toward gonadal/testicular gene expression compared to undifferentiated stem cells

  hipscs day degs testis-like bulk single-cell term

• The Genetic Architecture of Venom Resistance: A Novel Approach to Target Identification and Coevolutionary Discovery.

  PMID 41739857 · PMC12978544 · Molecular biology and evolution · 2026 · 8 claims · 5 setups

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  12 consensus candidate genes were identified across E&R and XQTL techniques as associated with venom resistance

  scolopendra drosophila sequenced genome phenotypic evolve

• Main Factors Influencing the Gut Microbiota of Datong Yaks in Mixed Group.

  PMID 35883324 · PMC9312300 · Animals : an open access journal from MDPI · 2022 · 7 claims · 6 setups

  Has reproduction · 84

  Gut microbial diversity (alpha and beta) differs significantly among domestic males, domestic females, and wild male Datong yaks.

  fresh fecal 16s alpha-diversity beta-diversity

• Differential neuronal survival defines a novel axis of sexual dimorphism in the Drosophila brain.

  PMID 41529688 · PMC7618834 · Cell genomics · 2026 · 8 claims · 7 setups

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  Sex differences in the Drosophila central brain do not result from large-scale transcriptional reprogramming, but from selective modifications within shared developmental lineages mediated by dsx and fru.

  drosophila central dsx+ dsx-gal4>mcd8 single-cell differential scenic

• Revised annotations, sex-biased expression, and lineage-specific genes in the Drosophila melanogaster group.

  PMID 25273863 · PMC4267930 · G3 (Bethesda, Md.) · 2014 · 8 claims · 6 setups

  Has reproduction · 58

  Revised RNA-seq-based gene models for D. ananassae, D. yakuba, and D. simulans include UTRs, empirically verified intron-exon boundaries, and previously unannotated novel exons, improving on r1.3 comparative-genomics annotations that lack UTRs.

  dissected concatenated yakuba reference whole-transcriptome novo read

• Transcriptomics Reveal Molecular Signatures of a Resolved Sexual Conflict and Potential Association With Colour Polymorphism in Tawny Owls.

  PMID 41964128 · PMC13069001 · Molecular ecology · 2026 · 8 claims · 8 setups

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  Substantial sex-specific variation exists in differentially expressed genes, SNPs and alternative exon usage in genes involved in life history traits (ZGRF1, VLDLR), behaviour (GSK3B, SLC12A) and growth (GHR, EGF, EPS8L2)

  feather tawny sex individual bulk genome read

• Genetic polymorphisms in monoamine neurotransmitter systems show only weak association with acute post-surgical pain in humans.

  PMID 16848906 · PMC1543620 · Molecular pain · 2006 · 8 claims · 5 setups

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  COMT SNP5 (rs740603, intron 1) shows significant association with maximum post-operative pain rating

  surgical candidate haplotype allele

• AI-assisted discovery of an ethnicity-influenced driver of cell transformation in esophageal and gastroesophageal junction adenocarcinomas.

  PMID 36134663 · PMC9675486 · JCI insight · 2022 · 8 claims · 8 setups

  Has reproduction · 84

  An AI-guided Boolean network approach (BoNE) models transcriptomic continuum states of normal esophagus, BE, and EAC to derive classifier gene signatures

  gene keratinocyte-derived ffpe spt6-depleted boolean rna-seq immunohistochemistry

• Identification of a novel 10 immune-related genes signature as a prognostic biomarker panel for gastric cancer.

  PMID 34382341 · PMC8446556 · Cancer medicine · 2021 · 8 claims · 8 setups

  Has reproduction

  A 10-IRG prognostic signature (BMPR1B, GHR, IL11RA, INHBB, NPR3, OBP2A, PTN, R3HDML, TAC1, TPM2) predicts overall survival in gastric cancer.

  gastric tcga-stad overlapping candidate microarray gene rna-seq

• Integrative analysis of transcriptomic data reveals a predictive gene signature for chemoradiotherapy response in rectal cancer.

  PMID 41550766 · PMC12803930 · iScience · 2026 · 8 claims · 8 setups

  Has reproduction · 50

  A 186-gene signature predictive of nCRT response was derived from integrating six GEO transcriptomic datasets using machine learning.

  pre-treatment combined larc 186-gene differential machine molecular

• Association between Arsenic Level, Gene Expression in Asian Population, and In Vitro Carcinogenic Bladder Tumor.

  PMID 35039759 · PMC8760535 · Oxidative medicine and cellular longevity · 2022 · 8 claims · 8 setups

  Has reproduction

  A unique set of 147 genes associated with arsenic exposure links to molecular mechanisms of cancer

  blood myeloma bladder differentially microarray gene pls-da

• Multi-omic identification of key transcriptional regulatory programs during endurance exercise training in rats.

  PMID 41862462 · PMC13168590 · Nature communications · 2026 · 8 claims · 7 setups

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  Gene regulatory responses to endurance exercise training (EET) are predominantly tissue-specific rather than shared across tissues

  tissues same skm-gn rna-seq atac-seq rrbs

• Application of genomics to toxicology research.

  PMID 12634120 · PMC1241273 · Environmental health perspectives · 2002 · 8 claims · 3 setups

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  Toxic chemical exposures alter gene expression, producing a diagnostic transcriptional 'fingerprint' that can be matched against known toxicants to classify untested chemicals' toxic potential.

  yeast rodents rodent microarray proposed cross-species

• PDLIM2 repression: a common mechanism in viral lung infection.

  PMID 41904702 · PMC13168810 · ImmunoHorizons · 2026 · 8 claims · 7 setups

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  PDLIM2 expression is repressed in blood leukocytes, BAL cells, and lung tissue of patients infected with influenza or SARS-CoV-2 compared to uninfected controls

  peripheral blood bal influenza gene bulk single-cell