Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• 7SL RNA and signal recognition particle orchestrate a global cellular response to acute thermal stress.

  PMID 39952919 · PMC11828898 · Nature communications · 2025 · 8 claims · 8 setups

  Has reproduction · 93

  Heat shock induces de novo transcription and nuclear accumulation of 7SL RNA together with SRP proteins, which then bind chromatin at promoters

  embryonic nih3t3 pro-seq fractionation fluorescence

• QTLs for heat-induced stomatal anatomy underpin gas exchange variation in field-grown wheat.

  PMID 42231893 · PMC13223016 · Frontiers in plant science · 2026 · 8 claims · 6 setups

  Has reproduction · 100

  Heat stress via delayed sowing reduces stomatal conductance (gs) and gas exchange efficiency (gse) despite unchanged theoretical maximum anatomical conductance (gsmax), revealing a decoupling of structural potential and physiological performance under stress.

  field-grown microscope wheat field stomatal in-field deep

• What's Genetic Variation Got to Do with It? Starvation-Induced Self-Fertilization Enhances Survival in Paramecium.

  PMID 32163147 · PMC7239694 · Genome biology and evolution · 2020 · 8 claims · 5 setups

  Has reproduction · 89

  Self-fertilization enhances heat shock resistance in P. tetraurelia in the absence of new genetic variation

  paramecium heat autogamy bulk

• Early life-stage thermal resilience is determined by climate-linked regulatory variation.

  PMID 41505517 · PMC12799179 · Proceedings of the National Academy of Sciences of the United States of America · 2026 · 8 claims · 8 setups

  Has reproduction · 64

  Embryonic heat tolerance in D. melanogaster is determined by climate-linked regulatory genetic variation at loci on chromosomes 2R and X

  melanogaster simulated synthetic wild-collected heat-shock pool-seq drift-only

• Transcriptional responses to proteotoxic stressors are profoundly diverse and tissue-specific.

  PMID 41619802 · PMC12908066 · Cell stress & chaperones · 2026 · 8 claims · 7 setups

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  Heat shock, HSP90 inhibition, and polyQ aggregation launch fundamentally distinct RNA expression programs rather than a shared stress response.

  muscle q175 striatum gene bulk enrichr principal

• Atypical pericapillary Ly6G⁺Nur77⁺ macrophages initiate type-2 immune responses to allergens in the mouse lung.

  PMID 41571657 · PMC12929616 · Nature communications · 2026 · 8 claims · 8 setups

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  Cysteine protease activity in HDM (and not LPS/TLR4 signaling) is the primary driver of Th2 allergic airway responses

  lung mediastinal par2 hematopoietic flow adoptive competitive

• Identification of key genes in chickpea transcriptomics and the development of ChickpeaOmicsR as a comprehensive resource to advance breeding and genomic studies.

  PMID 41909810 · PMC13022592 · Frontiers in bioinformatics · 2026 · 8 claims · 8 setups

  Has reproduction · 56

  ChickpeaOmicsR is the first comprehensive R package that integrates transcriptomic, genomic, and proteomic chickpea data, automates DEG/PPI/GWAS analyses, and standardizes fragmented chickpea gene nomenclature

  cicer bulk gwas protein-protein

• Integrative Transcriptomic and Evolutionary Analysis of Drought and Heat Stress Responses in Solanum tuberosum and Solanum lycopersicum.

  PMID 41470732 · PMC12736803 · Plants (Basel, Switzerland) · 2025 · 7 claims · 8 setups

  Has reproduction · 84

  Drought and heat stress induce coordinated transcriptional reprogramming in potato and tomato: induction of molecular chaperone activity, oxidative stress responses, and immune signaling, with repression of photosynthetic and primary metabolic pathways reflecting energy reallocation.

  solanum bulk term novo

• Stress testing reveals selective vulnerabilities in protein homeostasis.

  PMID 41575849 · PMC13040462 · Cell reports · 2026 · 8 claims · 8 setups

  Full-text index only

  Tn-seq fitness profiling across strains lacking major chaperones/proteases under proteotoxic stress reveals stress- and strain-specific fitness determinants otherwise masked by redundancy

  caulobacter transposon growth sequencing

• The use of neuroproteomics in drug abuse research.

  PMID 19926406 · PMC3947580 · Drug and alcohol dependence · 2010 · 8 claims · 8 setups

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  Neuroproteomic technologies (2D-DIGE, iTRAQ, ICAT, etc.) enable identification of protein-level changes underlying effects of drugs of abuse such as amphetamine, morphine, cocaine, and alcohol.

  rodent brain postmortem sectioned 2d-dige itraq heat

• Proteomic revelation: SUMO changes partners when the heat is on.

  PMID 19638612 · PMC2825085 · Science signaling · 2009 · 8 claims · 4 setups

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  A quantitative, system-wide MS approach combining TAP-SUMO-2 purification and triple-SILAC labeling reveals dynamic changes in SUMO-2 modification during heat shock and recovery

  hela affinity western sirna

• Transcriptomic and chromatin accessibility profiling unveils new regulators of heat hormesis in Caenorhabditis elegans.

  PMID 41719228 · PMC12923026 · PLoS biology · 2026 · 7 claims · 6 setups

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  A 30°C 6-hour priming regimen significantly enhances thermotolerance and survival after subsequent heat shock in both WT and glp-1(ts) C. elegans

  elegans thermotolerance survival rna-seq

• Differentiating Drosophila female germ cells initiate Polycomb silencing by regulating PRC2-interacting proteins.

  PMID 32773039 · PMC7438113 · eLife · 2020 · 8 claims · 2 setups

  Has reproduction · 87

  Germline stem cells (GSCs) have a non-canonical PRC2 distribution and lack silenced chromatin, resembling early embryonic progenitors

  drosophila facs-purified hsgfp chipseq

• Cancer-cell-secreted miR-204-5p induces leptin signalling pathway in white adipose tissue to promote cancer-associated cachexia.

  PMID 37620316 · PMC10449837 · Nature communications · 2023 · 8 claims · 8 setups

  Has reproduction · 85

  Breast cancer cell-secreted exosomal miR-204-5p induces HIF1A in white adipose tissue by targeting the VHL gene.

  balb nsg ewat iwat orthotopic indirect sev

• Synthesis of transcriptomic studies reveals a core response to heat stress in abalone (genus Haliotis).

  PMID 40361012 · PMC12070547 · BMC genomics · 2025 · 7 claims · 8 setups

  Has reproduction · 80

  A core set of 74 differentially expressed genes (DEGs) responds to heat stress in at least 7 of 9 independent abalone RNA-seq studies

  haliotis bulk

• SMRT and Illumina RNA sequencing reveal novel insights into the heat stress response and crosstalk with leaf senescence in tall fescue.

  PMID 32746857 · PMC7397585 · BMC plant biology · 2020 · 8 claims · 7 setups

  Has reproduction · 30

  Combined PacBio SMRT and Illumina RNA sequencing generated a full-length reference transcriptome for tall fescue in the absence of a genome sequence.

  tall pooled nicotiana physiological illumina smrt

• Molecular characterization of Campylobacter jejuni clones: a basis for epidemiologic investigation.

  PMID 12194772 · PMC2732546 · Emerging infectious diseases · 2002 · 8 claims · 5 setups

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  Clonal complex, as defined by MLST, is an epidemiologically relevant unit for long- and short-term investigation of C. jejuni epidemiology.

  jejuni same clonal mlst multilocus heat-stable flaa

• Transgenerational inheritance of an acquired small RNA-based antiviral response in C. elegans.

  PMID 22119442 · PMC3250924 · Cell · 2011 · 8 claims · 8 setups

  Has reproduction · 68

  viRNA-mediated silencing of the FR1gfp Flock House virus is transmitted to RNAi-deficient (rde-1 or rde-4 homozygous) progeny and persists for many ensuing generations, i.e. an acquired antiviral trait is inherited.

  transgenic elegans four gfp genetic template-independence

• Use of functional genomics to understand influenza-host interactions.

  PMID 17765704 · PMC7112328 · Advances in virus research · 2007 · 8 claims · 8 setups

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  Functional genomics/microarray analysis provides a global view of host response to influenza infection that reveals virus-host interaction mechanisms not accessible by conventional techniques

  hela a549 lung texas cdna microarray infection

• Signatures of Innovation and Selection in the Extremotolerant Yeast Kluyveromyces marxianus.

  PMID 41874284 · PMC13011806 · Genome biology and evolution · 2026 · 8 claims · 9 setups

  Full-text index only

  K. marxianus shows a unique stress-resistance syndrome (heat, ethanol, caffeine, propidium iodide, MMS) relative to other Kluyveromyces species

  kluyveromyces marxianus one-to-one liquid heat-shock stress