Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Dynamics and regulation of mitotic chromatin accessibility bookmarking at single-cell resolution.

  PMID 36696508 · PMC9876548 · Science advances · 2023 · 7 claims · 8 setups

  Has reproduction · 50

  Chromatin accessibility continually decreases from mitotic entry until metaphase, then gradually increases as chromosomes segregate.

  l02 tissues hepatoma scatac-seq immunofluorescence atac-see

• The TRIP12's intrinsically disordered region induces chromatin condensates and interferes with nuclear processes.

  PMID 41660270 · PMC12876695 · iScience · 2026 · 8 claims · 8 setups

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  TRIP12 overexpression induces dose-dependent formation of chromatin condensates enriched in heterochromatin marks

  hela u2os trip12 immunofluorescence cellular isoelectric

• PAF15-PCNA exhaustion governs the strand-specific control of DNA replication.

  PMID 41606318 · PMC12979207 · Nature · 2026 · 8 claims · 8 setups

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  Excessive origin firing saturates chromatin-bound PCNA, restricting further PCNA loading and lagging-strand synthesis when checkpoint control is lost.

  u2os embryonic qibc confocal western

• ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia.

  PMID 22955991 · PMC3431496 · Genome research · 2012 · 8 claims · 8 setups

  Has reproduction · 74

  ENCODE/modENCODE define a set of working standards and guidelines for ChIP-seq covering antibody validation, experimental replication, sequencing depth, data/metadata reporting, and data quality assessment.

  small-genome nuclear whole-cell encode chip-seq chip-chip immunoblot

• Nonsense-mediated mRNA decay orchestrates neuronal migration and cortical lamination while modulating Reelin and ciliary gene regulatory networks.

  PMID 41746809 · PMC13042203 · Cell reports · 2026 · 8 claims · 8 setups

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  UPF2-mediated NMD is required for proper cortical lamination; conditional Upf2 deletion in radial glia disrupts layering of TBR1+/SATB2+ and CTIP2+/CUX1+ neurons.

  cortex embryonic cortical neural immunofluorescence utero co-electroporation

• Feed-forward loops by NR5A2 ensure robust gene activation during pre-implantation development.

  PMID 41355514 · PMC12848575 · Development (Cambridge, England) · 2026 · 8 claims · 8 setups

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  NR5A2 chromatin binding is dynamic, changing genome-wide from the 2-cell to the morula stage, with peak numbers and target regions (e.g. SINE B1/Alu) shifting over developmental time

  2-cell embryonic 8-cell zygotes cut&tag chip-seq h3k27ac

• YAP/TAZ-VGLL3 governs adipocyte fate via epigenetic reprogramming of PPARγ and its target enhancers.

  PMID 41533786 · PMC12802833 · Science advances · 2026 · 8 claims · 8 setups

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  TAZ represses PPARγ-bound target enhancers, evidenced by markedly reduced H3K27ac occupancy, leading to transcriptional repression of adipogenic genes including Pparg2

  c3h10t1 inguinal iwat adipose atac-seq rna-seq immunoblot

• ASCL1 promotes nuclear shrinkage in transdifferentiation by suppressing NUP37.

  PMID 41759523 · PMC12985393 · Stem cell reports · 2026 · 7 claims · 8 setups

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  ASCL1-mediated transdifferentiation (AMp) of human fibroblasts to induced neurons causes marked nuclear shrinkage while cell size remains unchanged

  mrc5 ag22056 ipsc-derived embryonic immunofluorescence single-cell rt-qpcr

• Complete human day 14 post-implantation embryo models from naive ES cells.

  PMID 37673118 · PMC10584686 · Nature · 2023 · 8 claims · 8 setups

  Has reproduction · 100

  Genetically unmodified human naive ES cells, without transgene overexpression, can be aggregated to form complete SEMs recapitulating epiblast, hypoblast, extra-embryonic mesoderm and trophoblast compartments

  naive day igata3 sem facs immunofluorescence scrna-seq

• Cell-type- and chromosome-specific chromatin landscapes and DNA replication programs of Drosophila testis tumor stem cell-like cells.

  PMID 41371963 · PMC12758400 · Genome research · 2026 · 8 claims · 6 setups

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  GSC-like and CySC-like cells isolated from upd tumor testes are transcriptionally comparable to wild-type GSC/early-spermatogonia and CySC clusters, respectively

  upd gsc-like wild-type scrna-seq differential gene

• Epigenetic loss of heterogeneity from low to high grade localized prostate tumours.

  PMID 34911933 · PMC8674326 · Nature communications · 2021 · 8 claims · 7 setups

  Has reproduction · 79

  Low-grade (Gleason pattern 3) prostate cancer cells share chromatin accessibility features that are lost in high-grade (Gleason pattern 4) tumours

  flash-frozen tcga single differentially single-cell bulk topic

• Global reorganization of genome architecture at the transition to gametogenesis.

  PMID 41721019 · PMC12999497 · Nature structural & molecular biology · 2026 · 8 claims · 8 setups

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  Premeiotic gonadal germ cells display a distinct chromosome and genome architecture concomitant with commitment to gametogenesis, involving separation of individual chromosomes, peripheral centromere anchoring, reduced interchromosomal interactions and disentangled chromosome ends

  e13.5 e9.5 gonadal facs-sorted transmission immunofluorescence minor

• Protease-mediated PRC1 dissociation promotes H2AK119ub remodeling during stress responses.

  PMID 41813846 · PMC13083880 · The EMBO journal · 2026 · 8 claims · 8 setups

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  CAPN3 promotes rapid dissociation of PRC1 complexes from chromatin in response to stress

  hepatocytes liver doxycycline-inducible capn3 chip-seq cut&tag western

• Multiomics Analysis of Arboviral Capsid Targets in Mosquitoes Reveals a Proviral Function of the Chromatin-Remodeling Brahma Complex.

  PMID 41565204 · PMC12927048 · Molecular & cellular proteomics : MCP · 2026 · 7 claims · 8 setups

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  Capsids from 11 pathogenic arboviruses spanning 3 genera (Orthoflavivirus, Orthobunyavirus, Alphavirus) interact with distinct sets of Aedes aegypti host proteins, forming a multimodal PPI atlas.

  aag2 aag2-c3 ap-ms dsrna co-immunoprecipitation

• Understanding the function of Pax5 in development of docetaxel-resistant neuroendocrine-like prostate cancers.

  PMID 39183332 · PMC11345443 · Cell death & disease · 2024 · 7 claims · 8 setups

  Has reproduction · 69

  Pax5 is an important transcription factor driving neuronal gene expression and is specific to t-NEPC

  ne-like prostate lucap mcrpc atac-seq acetylated-histone rna-seq

• Development of double-positive thymocytes at single-cell resolution.

  PMID 33771202 · PMC8004397 · Genome medicine · 2021 · 7 claims · 8 setups

  Has reproduction · 86

  DP thymocytes can be classified into blast, rearrangement, and selection subtypes, distinguishable by surface markers CD2 and Ly6d

  thymocytes sorted thymocyte scrna-seq flow immunofluorescence

• Proteomic screen defines the hepatocyte nuclear factor 1alpha-binding partners and identifies HMGB1 as a new cofactor of HNF1alpha.

  PMID 18160415 · PMC2275099 · Nucleic acids research · 2008 · 8 claims · 8 setups

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  HMGB1 is a novel HNF1α-interacting protein identified via a co-IP-MS screening strategy

  hepg2 recombinant co-immunoprecipitation immunofluorescence gst

• Contribution of the C-terminal region within the catalytic core domain of HIV-1 integrase to yeast lethality, chromatin binding and viral replication.

  PMID 19014595 · PMC2615443 · Retrovirology · 2008 · 7 claims · 8 setups

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  IN mutants V165A, A179P and KR186,7AA in the C-terminal region of the catalytic core domain fail to induce the lethal phenotype in HP16 yeast

  saccharomyces hp16 293t cos-7 yeast immunoprecipitation chromatin

• A naturally occurring human RPA subunit homolog does not support DNA replication or cell-cycle progression.

  PMID 19942684 · PMC2817474 · Nucleic acids research · 2010 · 8 claims · 7 setups

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  Exogenous RPA4 expression does not support chromosomal DNA replication and causes cell-cycle arrest in G2/M

  hela mammalian rpa4 western flow immunofluorescence

• Single-cell epigenetic profiling reveals a tumor-intrinsic interferon response program in ccRCC tied to poor prognosis and BAP1 loss.

  PMID 41719400 · PMC12922754 · Science advances · 2026 · 8 claims · 8 setups

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  Subclustering of ccRCC tumor cells reveals four shared epigenetic programs (C0-C3) recurrent across patients, cohorts, and disease stages

  rcc internal tumor state-specific single-cell multiome copy