Experiments
Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).
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SMARCB1 missense mutants disrupt SWI/SNF complex stability and remodeling activity.
PMID 41951591 · PMC13237135 · Nature communications · 2026 · 8 claims · 8 setups
RPT2 domain missense mutations disrupt SMARCB1 antiproliferative function by destabilizing the SWI/SNF complex and impairing chromatin remodeling and transcriptional regulation, comparable to nonsense mutations
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Engineered apoptotic nucleases for chromatin research.
PMID 17626049 · PMC1935020 · Nucleic acids research · 2007 · 8 claims · 6 setups
Inserting TEVP cleavage sites immediately downstream of the two caspase-3 sites in DFF45 (I1I2 mutant) makes DFF40 nuclease activity exclusively dependent on TEVP cleavage (DFF-T)
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Has reproduction · 100
Complete human day 14 post-implantation embryo models from naive ES cells.
PMID 37673118 · PMC10584686 · Nature · 2023 · 8 claims · 8 setups
Genetically unmodified human naive ES cells, without transgene overexpression, can be aggregated to form complete SEMs recapitulating epiblast, hypoblast, extra-embryonic mesoderm and trophoblast compartments
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Kinetoplastid genomics: the thin end of the wedge.
PMID 18675383 · PMC2676795 · Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2008 · 8 claims · 8 setups
Completion of the T. brucei, T. cruzi, and L. major genome sequencing projects enabled numerous studies that would otherwise have been difficult or impossible.