Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Toward accurate high-throughput SNP genotyping in the presence of inherited copy number variation.

  PMID 17608949 · PMC1934372 · BMC genomics · 2007 · 7 claims · 5 setups

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  Developed a statistical model-fitting method to infer generalized (multi-allelic, copy-number-aware) genotypes from raw SNP microarray data

  individuals mother-father-child transcribed snp quantitative multiplex

• Tractor workflow: a scalable Nextflow framework for local ancestry-aware genome-wide association studies.

  PMID 41838407 · PMC13197121 · Bioinformatics (Oxford, England) · 2026 · 7 claims · 6 setups

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  Developed a scalable Nextflow workflow that automates phasing, local ancestry inference (LAI), and Tractor GWAS into a reproducible end-to-end pipeline

  biobank phased two-way simulated haplotype local gwas

• Bridging cancer cell-intrinsic driver genes and -extrinsic cell-cell communication with Driver2Comm.

  PMID 41701761 · PMC12928580 · PLoS computational biology · 2026 · 8 claims · 5 setups

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  Driver2Comm is a computational framework that identifies intrinsic-extrinsic (IE) pathways functionally connecting cancer cell driver genes with their associated CCC signatures in the TME using single-cell transcriptomics data.

  pdac genes tcga single-cell copy fisher's

• Systematic design of combination therapy by targeting master regulators of coexisting diffuse midline glioma cell states.

  PMID 42020604 · PMC13175895 · Nature genetics · 2026 · 8 claims · 6 setups

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  A generalizable, network-based framework was established to systematically identify combination therapies targeting complementary coexisting tumor cell states

  malignant eight patient-derived dmg single-cell pooled plate-seq

• Protocol for single-cell optimization objective and trade-off inference.

  PMID 41790544 · PMC12992945 · STAR protocols · 2026 · 6 claims · 6 setups

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  SCOOTI is a computational framework that integrates bulk and single-cell omics data with genome-scale metabolic modeling to infer metabolic objectives and trade-offs

  mcf10a serum-starved contact-inhibited zygote bulk scrna-seq genome-scale

• INDELSCAN: a web server for comparative identification of species-specific and non-species-specific insertion/deletion events.

  PMID 17517762 · PMC1933116 · Nucleic acids research · 2007 · 8 claims · 3 setups

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  Pair-wise sequence alignment-based indel identification lacks discrimination of species specificity and cannot distinguish insertions from deletions.

  chromosomes hg18 ucsc sequence pair-wise

• Differential cell signaling testing for cell-cell communication inference from single-cell data by dominoSignal.

  PMID 41746282 · PMC12998610 · Bioinformatics (Oxford, England) · 2026 · 8 claims · 5 setups

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  dominoSignal extends the Domino algorithm to enable statistical testing of differential cell-cell signaling between experimental conditions.

  single-cell simulated pdac per-sample single-cell simulation cell-cell

• Single cell analysis reveals the roles and regulatory mechanisms of type-I interferons in Parkinson's disease.

  PMID 38566100 · PMC10985960 · Cell communication and signaling : CCS · 2024 · 8 claims · 8 setups

  Has reproduction · 55

  Microglia, endothelial cells, and pericytes exhibit the highest IFN-I activity among PD midbrain cell types, with microglia and endothelial cells showing significantly elevated high-IFN-I-scoring proportions in PD versus controls

  midbrain single microglia substantia single-cell scenic monocle

• huSA: a comprehensive database for multi-dimensional resolution of bulk, single cell and spatial transcription profiles in skin diseases.

  PMID 41719583 · PMC12923168 · Database : the journal of biological databases and curation · 2026 · 7 claims · 8 setups

  Has reproduction · 50

  huSA is a comprehensive, publicly accessible database integrating bulk RNA-seq, scRNA-seq, and spatial transcriptomics data across 17 skin diseases and 63 independent datasets

  skin scrna-seq scrna-seq transcription cell-cell

• Predicting the protein interaction landscape of a free-living bacterium with pooled-AlphaFold3.

  PMID 41559189 · PMC13047044 · Molecular systems biology · 2026 · 8 claims · 6 setups

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  Pooled-AlphaFold3 prediction improves accuracy of genome-scale PPI screens compared to a paired approach while reducing inference time (~2-fold) and job count (~100-fold)

  mycoplasma subset genitalium simulated pooled paired benchmarking

• An integrated single-cell lung cancer atlas reveals distinct fibroblast phenotypes between adenocarcinoma and squamous cell carcinomas.

  PMID 41577803 · PMC12920623 · NPJ precision oncology · 2026 · 8 claims · 8 setups

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  Inflammatory CAFs (iCAFs) predominate in LUAD, whereas myofibroblastic CAFs (mCAFs) predominate in LUSC

  nsclc epithelial macrophage caf scrna-seq copy gene-set

• A differential single-cell transcriptome atlas of left-sided and right-sided colorectal cancer.

  PMID 41844817 · PMC13111741 · Discover oncology · 2026 · 8 claims · 8 setups

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  MTRNR2L8 is markedly upregulated in RCRC tumor cells and is associated with poorer patient survival

  crc epithelial rcrc tcga-read scrna-seq copy gene

• Dynamic changes of the immune microenvironment in ovarian cancer following neoadjuvant chemotherapy.

  PMID 41872134 · PMC13039919 · Cell death discovery · 2026 · 8 claims · 8 setups

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  Prostaglandin-mediated immunosuppressive microenvironment formation is a critical contributor to chemotherapy resistance following cisplatin treatment

  high-grade hgsoc bone bmdms scrna-seq cell-cell tensor

• A Single-Cell Atlas of Pan-Cancer Liver Metastasis Reveals Dynamic Cellular Programs Driving Metastatic Progression and Immune Modulation.

  PMID 41884334 · PMC13010057 · Research (Washington, D.C.) · 2026 · 8 claims · 4 setups

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  A pan-cancer single-cell transcriptomic atlas of liver metastasis was constructed from 100 scRNA-seq samples (75 individuals, 16 studies), profiling 460,337 cells into 121 distinct cellular subtypes.

  epithelial liver-related scrna-seq copy cellular

• PMEPA1 modulates YAP1 nuclear translocation to disrupt EMT subtypes and promote metastasis in Biliary tract cancer.

  PMID 41932868 · PMC13172513 · Cell death & disease · 2026 · 8 claims · 8 setups

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  PMEPA1 is a pivotal EMT regulator in BTC; its high expression correlates with adverse prognosis and distant metastasis

  btc tcga hucct1 scrna-seq cnmf bulk

• Benchmarking tools for deciphering cellular crosstalk in spatially-resolved transcriptomics.

  PMID 41952215 · PMC13174004 · Genome biology · 2026 · 8 claims · 5 setups

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  No prior systematic, quantitative benchmark exists for CCI inference methods specifically developed for spatial transcriptomics across multiple platforms

  synthetic real simulated simulation spot-purity real-data

• Single cell profiling reveals malignant states and immune landscapes in PCNSL and systemic DLBCL.

  PMID 42023148 · PMC13097095 · iScience · 2026 · 8 claims · 8 setups

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  PCNSL and sDLBCL contain five distinct malignant B-cell subtypes (B0-B4) with discrete differentiation trajectories

  pcnsl malignant bulk sdlbcl scrna-seq infercnv cytotrace2

• Therapeutic Targeting of Oxidative Phosphorylation in Microsatellite Instability-High Gastric Cancer.

  PMID 42038020 · PMC13104725 · Journal of Cancer · 2026 · 7 claims · 8 setups

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  MSI gastric cancer samples show significantly greater T cell infiltration and a lower proportion of epithelial cells compared to GS samples

  gastric epithelial stomach nod-scid single-cell cnv differential

• Metappuccino: large language model-driven reconstruction of sequence read archive metadata for cancer research.

  PMID 42057294 · PMC13148957 · Bioinformatics (Oxford, England) · 2026 · 8 claims · 3 setups

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  Metappuccino reconstructs 19 metadata classes by combining deterministic rule-based extraction/normalization (for explicit context) with LoRA-specialized Mistral-7B-Instruct completion (for missing/ambiguous fields)

  ncbi sra metadata llm-based rule-based

• Modeling genetic inheritance of copy number variations.

  PMID 18832372 · PMC2588508 · Nucleic acids research · 2008 · 8 claims · 4 setups

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  A joint HMM framework for parents-offspring trios significantly improves CNV call rates and boundary inference accuracy compared to existing methods.

  simulated parent-offspring hapmap hmm-based snp genotype