Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• The chromosomal genome sequence of the sponge Phakellia ventilabrum (Linnaeus, 1767) and its associated microbial metagenome sequences.

  PMID 41625985 · PMC12859430 · Wellcome open research · 2026 · 8 claims · 8 setups

  Full-text index only

  The Phakellia ventilabrum genome assembly spans 211.92 Mb with 99.97-99.98% scaffolded into 25 chromosomal pseudomolecules

  phakellia pacbio genome microbial pacbio hi-c sequencing

• The genome sequence of True's beaked whale, Mesoplodon mirus True, 1913 (Artiodactyla: Ziphiidae).

  PMID 41625987 · PMC12853023 · Wellcome open research · 2026 · 8 claims · 8 setups

  Full-text index only

  A genome assembly is presented for an individual female Mesoplodon mirus (True's beaked whale)

  mesoplodon pacbio hi-c sequencing

• The chromosomal genome sequence of the buttercup lucine, Anodontia alba Link, 1807 (Lucinida: Lucinidae) and its associated microbial metagenome sequences.

  PMID 41913758 · PMC13033139 · Wellcome open research · 2026 · 6 claims · 7 setups

  Full-text index only

  Genome assembly of Anodontia alba (buttercup lucine) with total length 1,862.85 Mb, 99.28% scaffolded into 18 chromosomal pseudomolecules

  anodontia microbial pacbio hi-c sequencing

• The genome sequence of a parasitoid wasp, Netelia inedita (Kokujev, 1899) (Hymenoptera: Ichneumonidae).

  PMID 41938268 · PMC13049423 · Wellcome open research · 2026 · 7 claims · 8 setups

  Full-text index only

  A genome assembly was generated for a female Netelia inedita specimen as part of the Darwin Tree of Life project

  netelia assembled pacbio hi-c sequencing

• The chromosomal genome sequence of the tubeworm, Lamellibrachia columna Southward, 1991 (Sabellida: Siboglinidae).

  PMID 41993727 · PMC13080331 · Wellcome open research · 2026 · 8 claims · 8 setups

  Full-text index only

  The Lamellibrachia columna genome assembly spans 879.73 Mb, with 99.96% scaffolded into 15 chromosomal pseudomolecules

  lamellibrachia columna filtered assembled pacbio hi-c sequencing

• The genome sequence of the Lesser Horseshoe Bat, Rhinolophus hipposideros (Bechstein, 1800) (Chiroptera: Rhinolophidae).

  PMID 42004187 · PMC13090764 · Wellcome open research · 2026 · 8 claims · 6 setups

  Full-text index only

  A phased, chromosome-level genome assembly was produced for Rhinolophus hipposideros as part of the Bat1K and Darwin Tree of Life projects.

  rhinolophus pacbio hi-c sequencing

• The genome sequence of the Acorn Weevil, Curculio glandium (T.Marsham, 1802) (Coleoptera: Curculionidae).

  PMID 42021765 · PMC13096787 · Wellcome open research · 2026 · 8 claims · 8 setups

  Full-text index only

  A chromosomally complete genome assembly was produced for Curculio glandium (Acorn Weevil) as part of the Darwin Tree of Life project

  curculio assembled alternate pacbio hi-c sequencing

• The chromosomal genome sequence of the sponge, Rhopaloeides odorabile Thompson, Murphy, Bergquist & Evans, 1987 (Dictyoceratida: Spongiidae) and its associated microbial metagenome sequences.

  PMID 42232316 · PMC13224822 · Wellcome open research · 2026 · 8 claims · 8 setups

  Full-text index only

  A chromosome-level genome assembly was produced for the sponge Rhopaloeides odorabile using the Tree of Life pipeline

  rhopaloeides odorabile-associated odorabile recovered pacbio hi-c sequencing

• Purinergic adipocyte-macrophage crosstalk promotes degeneration of thermogenic brown adipose tissue.

  PMID 41261284 · PMC12715258 · EMBO reports · 2025 · 8 claims · 8 setups

  Has reproduction · 78

  Imbalanced sympathetic/thermogenic activation (via UCP1 deficiency or pharmacological futile thermogenesis) causes BAT inflammation, fibrosis and degeneration

  bat wild-type brown histology qrt-pcr norepinephrine

• Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.

  PMID 30578418 · PMC6365102 · Nature genetics · 2019 · 7 claims · 8 setups

  Has reproduction

  208 novel common blood pressure SNPs and 53 rare variants were discovered in GWASs of SBP, DBP and pulse pressure in up to 776,078 participants from MVP and collaborating studies.

  multi-ethnic mvp tissues kidney genome-wide exome transcriptome-wide

• Spatially clustered loci with multiple enhancers are frequent targets of HIV-1 integration.

  PMID 31492853 · PMC6731298 · Nature communications · 2019 · 8 claims · 8 setups

  Has reproduction · 77

  Recurrently targeted HIV-1 integration genes (RIGs) are proximal to super-enhancer (SE) genomic elements

  activated cd4+ cd3 jurkat chip-seq hiv-1 sequencing

• PDGFRA defines the mesenchymal stem cell Kaposi's sarcoma progenitors by enabling KSHV oncogenesis in an angiogenic environment.

  PMID 31881074 · PMC6980685 · PLoS pathogens · 2019 · 8 claims · 8 setups

  Has reproduction · 85

  Pα(+)S (PDGFRA-positive/SCA-1-positive) bone marrow-derived MSCs are KS spindle-cell progenitors

  bone k-pα nude flow viral immunofluorescence

• De novo identification of CD4(+) T cell epitopes.

  PMID 38658646 · PMC11093748 · Nature methods · 2024 · 7 claims · 8 setups

  Has reproduction · 83

  SABR-IIs (chimeric receptors linking a covalently attached peptide-MHC-II to CD28-CD3ζ signaling domains) present epitopes to CD4+ T cells and induce a readable NFAT-GFP/CD69 signal upon cognate TCR recognition

  nfat-gfp hla-dq8 5kc daudi nfat-gfp co-incubation species

• Exploring the prognostic and diagnostic value of lactylation-related genes in sepsis.

  PMID 39367086 · PMC11452377 · Scientific reports · 2024 · 8 claims · 7 setups

  Has reproduction · 73

  Intersecting sepsis-associated differentially expressed genes with a curated list of 332 lactylation genes yields 55 sepsis-related lactylation genes.

  peripheral overlapping geo pbmcs bulk kegg protein-protein

• Expression of neurofibromin 1 in colorectal cancer and cetuximab resistance.

  PMID 34779495 · PMC8611403 · Oncology reports · 2022 · 7 claims · 8 setups

  Has reproduction · 73

  NF1 is highly expressed in cetuximab-sensitive colorectal cancer cell lines (NCI-H508, Caco2) but weakly expressed in cetuximab-resistant lines (KM12C, SW480)

  crc cetuximab-sensitive nf1 cetuximab-resistant western sirna dapi

• Identification of the shared hub gene signatures and molecular mechanisms between HIV-1 and pulmonary arterial hypertension.

  PMID 38528047 · PMC10963360 · Scientific reports · 2024 · 6 claims · 8 setups

  Has reproduction · 71

  109 shared genes were identified between HIV-1- and PAH-associated WGCNA modules

  pbmc shared hub pbmcs weighted kegg differential

• Distinct sympathetic projections to brown fat regulate thermogenesis and glucose tolerance.

  PMID 41559445 · PMC12945688 · Nature metabolism · 2026 · 8 claims · 8 setups

  Has reproduction · 85

  Distinct sympathetic neuron subpopulations in the stellate ganglion (SG) innervating iBAT parenchyma versus its vasculature mediate separable functions of the depot.

  th-cre awake ibat plasma retrograde chemogenetic indirect

• Single-cell transcriptomics reveals maturation of transplanted stem cell-derived retinal pigment epithelial cells toward native state.

  PMID 37339216 · PMC10293804 · Proceedings of the National Academy of Sciences of the United States of America · 2023 · 8 claims · 8 setups

  Has reproduction · 59

  Subretinally transplanted stem cell-derived RPE (ESC- and iPSC-derived) retain RPE identity and survive in vivo for at least 30 days in immunocompetent rabbit eyes

  hpsc-derived day esc dutch qrt-pcr immunofluorescence transepithelial

• Machine learning-based identification of an immunotherapy-related signature to enhance outcomes and immunotherapy responses in melanoma.

  PMID 39355255 · PMC11442245 · Frontiers in immunology · 2024 · 8 claims · 8 setups

  Has reproduction · 69

  66 consensus immunotherapy prognostic genes (CITPGs) were identified from the intersection of WGCNA modules, immunotherapy responder-vs-non-responder DEGs, and tumor-vs-normal DEGs

  melanoma tcga-skcm prjeb23709 microarray wgcna differential consensus

• Cancer cells copy migratory behavior and exchange signaling networks via extracellular vesicles.

  PMID 29907695 · PMC6068466 · The EMBO journal · 2018 · 8 claims · 8 setups

  Has reproduction · 46

  B16F1 and B16F10 melanoma subclones functionally exchange EVs in vivo, transferring Cre mRNA cargo detectable via a Cre-LoxP color-switch reporter system

  co-injected b16f1 locally 16.5k intravital cre-loxp rt-pcr