Experiments
Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).
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Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals.
PMID 18567819 · PMC2518495 · Diabetes · 2008 · 8 claims · 3 setups
UPR/ER stress-related proteins (calreticulin, PDI A3, glutathione-S-transferase P) are upregulated in adipose tissue of obese versus lean humans
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Proteomics analysis of human skeletal muscle reveals novel abnormalities in obesity and type 2 diabetes.
PMID 19833877 · PMC2797941 · Diabetes · 2010 · 7 claims · 5 setups
Mitochondrial protein abundance is decreased in insulin-resistant (obese and type 2 diabetic) skeletal muscle
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Has reproduction
Thermogenic adipocytes promote HDL turnover and reverse cholesterol transport.
PMID 28422089 · PMC5399294 · Nature communications · 2017 · 8 claims · 8 setups
Pharmacological (CL316,243) activation of thermogenic adipocytes increases HDL-cholesterol and reduces atherosclerosis in E3L.CETP mice, with HDL-cholesterol an independent predictor of atherosclerosis
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Full-text index only
WNT10B mutations in human obesity.
PMID 16477437 · PMC4304000 · Diabetologia · 2006 · 8 claims · 8 setups
The WNT10B C256Y missense mutation abrogates the protein's ability to activate canonical WNT signalling and block adipogenesis
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Has reproduction
Endogenous Fatty Acid Synthesis Drives Brown Adipose Tissue Involution.
PMID 33440156 · PMC8240962 · Cell reports · 2021 · 8 claims · 8 setups
Endogenous fatty acid synthesis (DNL), regulated by ChREBP, is the central driver of BAT whitening/involution at thermoneutrality.