Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

Publications 1.3k Datasets 392.5k Experiments 21

System / cell line: obese ✕ Clear

Exploration of the shared diagnostic genes and molecular mechanism between obesity and atherosclerosis via bioinformatic analysis.

PMID 39825072 · PMC11742665 · Scientific reports · 2025 · 8 claims · 8 setups

Has reproduction · 76

SAMSN1 and PHGDH are shared diagnostic genes for both obesity and atherosclerosis.

obese atherosclerotic shared validation microarray wgcna lasso
Meta-analysis of gene expression profiles of lean and obese PCOS to identify differentially regulated pathways and risk of comorbidities.

PMID 32695266 · PMC7352056 · Computational and structural biotechnology journal · 2020 · 8 claims · 8 setups

Has reproduction · 78

The majority of differentially expressed genes in PCOS are downregulated regardless of tissue type and phenotype

lutein subcutaneous cumulus skeletal microarray pathway
Mutation screen and association studies in the diacylglycerol O-acyltransferase homolog 2 gene (DGAT2), a positional candidate gene for early onset obesity on chromosome 11q13.

PMID 17477860 · PMC1871603 · BMC genetics · 2007 · 7 claims · 5 setups

Full-text index only

DGAT2 is a plausible positional and functional candidate gene for obesity due to its localization at chr.11q13 (a linkage region) and its key role in triglyceride synthesis

extremely families genome sanger case-control family-based
Implications of gene-behavior interactions: prevention and intervention for obesity.

PMID 19037218 · PMC2703301 · Obesity (Silver Spring, Md.) · 2008 · 8 claims · 8 setups

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Obesity has a strong genetic basis and multifactorial etiology, not attributable solely to food abundance and lack of exercise opportunity

adults african-american genetic
Proteomics analysis of human skeletal muscle reveals novel abnormalities in obesity and type 2 diabetes.

PMID 19833877 · PMC2797941 · Diabetes · 2010 · 7 claims · 5 setups

Full-text index only

Mitochondrial protein abundance is decreased in insulin-resistant (obese and type 2 diabetic) skeletal muscle

skeletal volunteers bsa shotgun euglycemic-hyperinsulinemic immunoblot
Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals.

PMID 18567819 · PMC2518495 · Diabetes · 2008 · 8 claims · 3 setups

Full-text index only

UPR/ER stress-related proteins (calreticulin, PDI A3, glutathione-S-transferase P) are upregulated in adipose tissue of obese versus lean humans

subcutaneous same adipose two-dimensional western real-time
D2H2: diabetes data and hypothesis hub.

PMID 38107655 · PMC10723036 · Bioinformatics advances · 2023 · 6 claims · 5 setups

Has reproduction

D2H2 is a web portal hosting hundreds of curated, uniformly reprocessed diabetes-relevant transcriptomics datasets from GEO with per-study visualization, differential expression, and single-gene queries.

obese type pubmed bulk single-cell single-gene
Systematic Analysis of Long Non-Coding RNA Genes in Nonalcoholic Fatty Liver Disease.

PMID 35893239 · PMC9332188 · Non-coding RNA · 2022 · 6 claims · 5 setups

Has reproduction · 85

Many lncRNAs, like protein-coding genes, are differentially expressed in NAFLD patients compared to healthy normal-weight and obese individuals.

liver huh-7 bulk sirna lipid
WNT10B mutations in human obesity.

PMID 16477437 · PMC4304000 · Diabetologia · 2006 · 8 claims · 8 setups

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The WNT10B C256Y missense mutation abrogates the protein's ability to activate canonical WNT signalling and block adipogenesis

genomic 3t3-l1 subject proband dhplc top-flash western
Improved weight management using genetic information to personalize a calorie controlled diet.

PMID 17945020 · PMC2151062 · Nutrition journal · 2007 · 7 claims · 4 setups

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Personalizing a weight-management diet using nutrigenetic test results improves long-term BMI reduction and weight loss maintenance compared to a standard diet.

buccal patients serum genotyping case-control fasting
Use of pyrosequencing and DNA barcodes to monitor variations in Firmicutes and Bacteroidetes communities in the gut microbiota of obese humans.

PMID 19046425 · PMC2625370 · BMC genomics · 2008 · 6 claims · 7 setups

Full-text index only

Identified a 12-bp Bacteroidetes DNA barcode and a 26-bp degenerate Firmicutes DNA barcode within the 16S rRNA gene

16s brain cystic caecal barcode 16s metagenome
Genetic variation in PARL influences mitochondrial content.

PMID 19862556 · PMC2829432 · Human genetics · 2010 · 7 claims · 5 setups

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PARL is a key regulator of mitochondrial integrity and function and plays a role in cellular apoptosis

genomic nuclear parl pcr snp real-time
Gene-environment interaction and obesity.

PMID 19019037 · PMC3683966 · Nutrition reviews · 2008 · 8 claims · 8 setups

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Obesity susceptibility is largely genetically determined but requires environmental exposure (excess energy intake, low fiber, physical inactivity) to manifest phenotypically.

framingham european individuals healthy genome-wide candidate gene-diet
Activation instead of blocking mesolimbic dopaminergic reward circuitry is a preferred modality in the long term treatment of reward deficiency syndrome (RDS): a commentary.

PMID 19014506 · PMC2615745 · Theoretical biology & medical modelling · 2008 · 8 claims · 6 setups

Full-text index only

A biphasic treatment approach—acute DA receptor blocking followed by long-term DA release/activation at the NAc—is needed to treat RDS without inducing abnormal mood or craving.

kidney alcohol-preferring obese rodents receptor dna-directed meta-analysis
MtSNPscore: a combined evidence approach for assessing cumulative impact of mitochondrial variations in disease.

PMID 19758471 · PMC2745589 · BMC bioinformatics · 2009 · 8 claims · 5 setups

Full-text index only

MtSNPscore, a weighted scoring pipeline combining literature evidence, in silico predictions, and case/control frequency, can prioritize likely pathogenic mtDNA variations

sporadic mitochondrial reported ataxia mitochondrial functional compensatory
Thermogenic adipocytes promote HDL turnover and reverse cholesterol transport.

PMID 28422089 · PMC5399294 · Nature communications · 2017 · 8 claims · 8 setups

Has reproduction

Pharmacological (CL316,243) activation of thermogenic adipocytes increases HDL-cholesterol and reduces atherosclerosis in E3L.CETP mice, with HDL-cholesterol an independent predictor of atherosclerosis

c57bl hdl plasma peritoneal fplc lipidomics cholesterol
CD14(lo)CD301b(+) macrophages gathering as a proangiogenic marker in adipose tissues.

PMID 39645040 · PMC11745947 · Journal of lipid research · 2025 · 8 claims · 8 setups

Has reproduction · 59

CD14 deficiency alleviates high-fat diet–induced obesity and reduces body fat/weight in mice

epididymal adipose epwat bend.3 bulk scrna-seq rt-qpcr
NK2R control of energy expenditure and feeding to treat metabolic diseases.

PMID 39537932 · PMC11602716 · Nature · 2024 · 8 claims · 8 setups

Has reproduction · 87

NK2R activation is sufficient to suppress appetite centrally and increase energy expenditure peripherally

european-ancestry brain nk2r greenlandic gwas transcriptome-wide receptor
Insulin mutation screening in 1,044 patients with diabetes: mutations in the INS gene are a common cause of neonatal diabetes but a rare cause of diabetes diagnosed in childhood or adulthood.

PMID 18162506 · PMC7611804 · Diabetes · 2008 · 8 claims · 8 setups

Full-text index only

Heterozygous INS mutations are a common cause of permanent neonatal diabetes (PNDM) diagnosed before 6 months of age

peripheral patients mody young-onset pcr microsatellite variant
Endogenous Fatty Acid Synthesis Drives Brown Adipose Tissue Involution.

PMID 33440156 · PMC8240962 · Cell reports · 2021 · 8 claims · 8 setups

Has reproduction

Endogenous fatty acid synthesis (DNL), regulated by ChREBP, is the central driver of BAT whitening/involution at thermoneutrality.

bat fatty lipidomics qpcr

Experiments

Mutation screen and association studies in the diacylglycerol O-acyltransferase homolog 2 gene (DGAT2), a positional candidate gene for early onset obesity on chromosome 11q13.

Implications of gene-behavior interactions: prevention and intervention for obesity.

Proteomics analysis of human skeletal muscle reveals novel abnormalities in obesity and type 2 diabetes.

Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals.

WNT10B mutations in human obesity.

Improved weight management using genetic information to personalize a calorie controlled diet.

Use of pyrosequencing and DNA barcodes to monitor variations in Firmicutes and Bacteroidetes communities in the gut microbiota of obese humans.

Genetic variation in PARL influences mitochondrial content.

Gene-environment interaction and obesity.

Activation instead of blocking mesolimbic dopaminergic reward circuitry is a preferred modality in the long term treatment of reward deficiency syndrome (RDS): a commentary.

MtSNPscore: a combined evidence approach for assessing cumulative impact of mitochondrial variations in disease.

Insulin mutation screening in 1,044 patients with diabetes: mutations in the INS gene are a common cause of neonatal diabetes but a rare cause of diabetes diagnosed in childhood or adulthood.