Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Genomic analysis of bacteria in the Acute Oak Decline pathobiome.

  PMID 30625111 · PMC6412055 · Microbial genomics · 2019 · 7 claims · 7 setups

  Has reproduction · 100

  All studied members of the AOD lesion microbiota possess virulence genes associated with phytopathogens

  gibbsiella lonsdalea brenneria miseq genome novo comparative

• Intrinsic suppression of type I interferon production underlies the therapeutic efficacy of IL-15-producing natural killer cells in B-cell acute lymphoblastic leukemia.

  PMID 37217248 · PMC10231005 · Journal for immunotherapy of cancer · 2023 · 8 claims · 8 setups

  Has reproduction · 76

  High expression of IFN-I signaling/response genes (IFNAR1, IFNAR2, STAT1, MX1, OAS1) predicts favorable relapse-free survival in B-ALL patients

  cog b-all eμ-myc crispra gene-expression-based flow mass

• Assessing Bos taurus introgression in the UOA Bos indicus assembly.

  PMID 34922445 · PMC8684283 · Genetics, selection, evolution : GSE · 2021 · 7 claims · 6 setups

  Has reproduction · 86

  Aligning B. taurus samples to UOA_Brahman_1 detects up to 5 million more SNVs than aligning to ARS_UCD1.2, and aligning B. indicus samples to ARS_UCD1.2 detects 1.5 million more SNVs than aligning to UOA_Brahman_1, demonstrating reference-genome bias.

  cattle same per-breed merged whole-genome snv principal

• Integrated drug resistance and leukemic stemness gene-expression scores predict outcomes in large cohort of over 3500 AML patients from 10 trials.

  PMID 39090192 · PMC11294346 · NPJ precision oncology · 2024 · 7 claims · 6 setups

  Has reproduction · 50

  A 5-gene ADE-Resistance Score (ADE-RS5), derived via LASSO regression from 67 pharmacologically relevant genes, predicts MRD positivity, EFS and OS in pediatric AML.

  pediatric combined lasso gene-expression-based integrated

• Enterotoxins A and B produced by Staphylococcus aureus increase cell proliferation, invasion and cytarabine resistance in acute myeloid leukemia cell lines.

  PMID 37810000 · PMC10559070 · Heliyon · 2023 · 8 claims · 8 setups

  Has reproduction · 88

  SEA and SEB treatment increases cell proliferation in AML cell lines

  aml cgp differentially proliferation culture transwell

• Assessment tool based on fatty acid metabolic signatures for predicting the prognosis and treatment response in bladder cancer.

  PMID 38076064 · PMC10703629 · Heliyon · 2023 · 8 claims · 8 setups

  Has reproduction · 71

  Consensus clustering of prognosis-related fatty acid metabolism genes (FAMGs) identifies three molecular subtypes of BLCA (FAMC1, FAMC2, FAMC3) with distinct prognoses and tumor microenvironments

  tcga-blca famc1-3 differentially gse32894 bulk consensus gene

• Protocol for assessing regulatory elements in murine heart using an AAV9-based massively parallel reporter assay.

  PMID 40252222 · PMC12033988 · STAR protocols · 2025 · 8 claims · 5 setups

  Has reproduction · 93

  An AAV9-based in vivo MPRA (AAV-MPRA) workflow, combined with a companion informatics platform, can dissect and quantify enhancer activity in mouse heart.

  agilent stbl3 hek293t wild-type self-annealing restriction plasmid

• Genome-wide identification and characterization of germin-like protein family in Brassica juncea reveals their role against biotic stress.

  PMID 41327045 · PMC12763953 · BMC plant biology · 2025 · 8 claims · 7 setups

  Has reproduction · 58

  Genome-wide identification revealed 102 GLPs in B. juncea, 51 in B. nigra, and 48 in B. rapa

  juncea promoter duplicated super genome-wide phylogenetic synteny

• Using prototyping to choose a bioinformatics workflow management system.

  PMID 33630841 · PMC7906312 · PLoS computational biology · 2021 · 7 claims · 6 setups

  Has reproduction

  Prototyping a subset of the RiboViz workflow in each candidate system gives more insight into suitability, ease of use, and documentation quality than reading documentation or working through developer tutorials alone

  workflow snakemake cwltool toil web repository prototype

• geneshot: gene-level metagenomics identifies genome islands associated with immunotherapy response.

  PMID 33952321 · PMC8097837 · Genome biology · 2021 · 8 claims · 6 setups

  Has reproduction · 75

  geneshot identifies microbial genomic islands consistently associated with ICI response across independent cohorts

  stool deduplicated cag reference gene-level novo co-abundance

• miRge3.0: a comprehensive microRNA and tRF sequencing analysis pipeline.

  PMID 34308351 · PMC8294687 · NAR genomics and bioinformatics · 2021 · 8 claims · 6 setups

  Has reproduction

  miRge3.0 is a Python 3-based small RNA-seq and tRF analysis pipeline that improves on miRge2.0 (which was Python 2.7-based)

  sra synthetic qiagen-processed same small umi mirna

• Acquisition and loss of CTX-M plasmids in Shigella species associated with MSM transmission in the UK.

  PMID 34427554 · PMC8549364 · Microbial genomics · 2021 · 8 claims · 8 setups

  Has reproduction · 92

  bla_CTX-M-27 is located on IncFII pKSR100-like plasmids, flanked by IS26 and IS903B

  sonnei same shigella assembled illumina oxford novo

• Frequency and patterns of ribonucleotide incorporation around autonomously replicating sequences in yeast reveal the division of labor of replicative DNA polymerases.

  PMID 34551434 · PMC8501979 · Nucleic acids research · 2021 · 6 claims · 4 setups

  Has reproduction · 75

  rNTP incorporation is preferentially found on the leading strand in yeast cells expressing wild-type replicative DNA polymerases

  saccharomyces model ribose-seq emriboseq rhii-hyden-seq

• nf-rnaSeqCount: A Nextflow pipeline for obtaining raw read counts from RNA-seq data.

  PMID 35574063 · PMC9097006 · South African computer journal = Suid-Afrikaanse rekenaartydskrif · 2021 · 7 claims · 5 setups

  Has reproduction · 95

  nf-rnaSeqCount is a portable, reproducible Nextflow pipeline that maps RNA-seq reads to a reference genome and quantifies gene abundance for differential expression analysis

  black geo rna-seq rna-seq benchmarking quality

• What the Phage: a scalable workflow for the identification and analysis of phage sequences.

  PMID 36399058 · PMC9673492 · GigaScience · 2022 · 8 claims · 7 setups

  Has reproduction · 76

  WtP combines 11 tools (14 approaches) for phage prediction in a parallel, containerized Nextflow workflow

  assembled illumina phage-predicted predicted multitool metagenome gene

• MoDLE: high-performance stochastic modeling of DNA loop extrusion interactions.

  PMID 36451166 · PMC9710047 · Genome biology · 2022 · 8 claims · 6 setups

  Has reproduction · 50

  MoDLE is a high-performance stochastic model/software for simulating DNA-DNA contacts generated by loop extrusion genome-wide

  h1-hesc five synthetic chip-seq stochastic molecular

• Single duplex DNA sequencing with CODEC detects mutations with high sensitivity.

  PMID 37106072 · PMC10181940 · Nature genetics · 2023 · 8 claims · 8 setups

  Has reproduction · 78

  CODEC concatenates both strands of an original DNA duplex into a single NGS read pair via an adapter quadruplex and strand-displacing extension, enabling single-duplex resolution

  cfdna na12878 genomic sperm targeted whole-genome whole-exome

• Genome-wide insights into population structure and host specificity of Campylobacter jejuni.

  PMID 33990625 · PMC8121833 · Scientific reports · 2021 · 8 claims · 6 setups

  Has reproduction · 94

  Both core and accessory genome characteristics show strong association with distinct host animal species, indicating multiple independent adaptive trajectories rather than a single common evolutionary path

  jejuni core whole-genome core k-mer

• B lymphocyte involvement in ankylosing spondylitis: the heavy chain variable segment gene repertoire of B lymphocytes from germinal center-like foci in the synovial membrane indicates antigen selection.

  PMID 11299060 · PMC30712 · Arthritis research · 2001 · 8 claims · 4 setups

  Full-text index only

  70 rearranged heavy chain VH genes from AS synovial membrane were characterized; 59 were potentially functional

  frozen lymphocytes microdissected pcr double microdissection semi-nested

• A case study for large-scale human microbiome analysis using JCVI's metagenomics reports (METAREP).

  PMID 22719821 · PMC3374610 · PloS one · 2012 · 8 claims · 7 setups

  Has reproduction · 78

  METAREP version 1.3.1 is an open-source, scalable tool for querying, browsing and comparing extremely large volumes of metagenomic annotations, with an extended data model, dynamic weighting, distributed searches and advanced clustering.

  microbiome pooled hmp metarep genome assembly-based enzymatic