Experiments
Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).
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Backseat drivers take the wheel.
PMID 18068625 · PMC2705833 · Cancer cell · 2007 · 8 claims · 8 setups
Systematic resequencing combined with functional validation can distinguish rare driver FLT3 mutations from passenger mutations in AML patients negative for known activating mutations
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The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells.
PMID 8551218 · PMC2192398 · The Journal of experimental medicine · 1996 · 8 claims · 8 setups
IFN-gamma primes phagocytic cells for LPS-induced transcription of the IL-12 p40 gene rather than directly inducing it
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Serum protein profile in systemic-onset juvenile idiopathic arthritis differentiates response versus nonresponse to therapy.
PMID 15987476 · PMC1175022 · Arthritis research & therapy · 2005 · 8 claims · 8 setups
SELDI-TOF MS can differentiate serum protein profiles of active versus well-controlled SJIA
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Targeted intracellular protein degradation induced by a small molecule: En route to chemical proteomics.
PMID 18752944 · PMC3175619 · Bioorganic & medicinal chemistry letters · 2008 · 7 claims · 2 setups
An all-small-molecule SARM-nutlin PROTAC induces degradation of the androgen receptor in cells
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Has reproduction · 84
Single-cell protein activity analysis reveals aberrant myogenesis and IGF2-PI3K pathway dependencies in MYOD1-mutant rhabdomyosarcoma.
PMID 41758938 · PMC12947870 · Science advances · 2026 · 7 claims · 8 setups
MYOD1 L122R-mutant SRMS comprises three coexisting tumor cell states (MYOD1-enriched progenitor-like, proliferative transition, and partially differentiated with reduced MYOD1 activity) reflecting disrupted myogenic differentiation.
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Detection of mutations in EGFR in circulating lung-cancer cells.
PMID 18596266 · PMC3551471 · The New England journal of medicine · 2008 · 8 claims · 7 setups
The CTC-chip microfluidic device isolates CTCs from NSCLC patients in sufficient quantity and purity to permit EGFR mutational analysis
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A key role for mitochondria in endothelial signaling by plasma cysteine/cystine redox potential.
PMID 19879942 · PMC3057402 · Free radical biology & medicine · 2010 · 8 claims · 8 setups
Mitochondria are a major source of ROS in the endothelial signaling response to a more oxidized extracellular EhCySS
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A genomic approach to improve prognosis and predict therapeutic response in chronic lymphocytic leukemia.
PMID 19861443 · PMC2783430 · Clinical cancer research : an official journal of the American Association for Cancer Research · 2009 · 8 claims · 8 setups
A genomic signature derived from CLL patient leukemic cells significantly differentiates stable from progressive disease
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Has reproduction · 88
Enterotoxins A and B produced by Staphylococcus aureus increase cell proliferation, invasion and cytarabine resistance in acute myeloid leukemia cell lines.
PMID 37810000 · PMC10559070 · Heliyon · 2023 · 7 claims · 7 setups
SEA and SEB treatment increases proliferation of AML cell lines.
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Evaluation of genome-wide chromatin library of Stat5 binding sites in human breast cancer.
PMID 15686596 · PMC549029 · Molecular cancer · 2005 · 8 claims · 5 setups
A chromatin library coupled with experimental validation can productively identify novel in vivo Stat5 chromatin binding sites in cancer, including abnormal regulatory sites in tumor-specific neochromatin.
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Analysis of nucleolar protein dynamics reveals the nuclear degradation of ribosomal proteins.
PMID 17446074 · PMC1885954 · Current biology : CB · 2007 · 8 claims · 8 setups
Newly synthesized ribosomal proteins accumulate in nucleoli more quickly than other nucleolar proteins
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High quality catalog of proteotypic peptides from human heart.
PMID 18803417 · PMC2765113 · Journal of proteome research · 2008 · 8 claims · 4 setups
A catalog of 4476 proteotypic peptides representing 2558 human heart proteins was generated from MudPIT analyses of nonfailing and failing left-ventricular explants
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Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics.
PMID 19651622 · PMC2816010 · Molecular & cellular proteomics : MCP · 2009 · 7 claims · 4 setups
Less than 10% of quantified phosphopeptides showed a response pattern indicative of being direct targets of the MAPK inhibitors U0126 or SB202190.
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How bacterial communities expand functional repertoires.
PMID 17238278 · PMC1750926 · PLoS biology · 2006 · 8 claims · 7 setups
The human microbiome contains roughly 100 times as many genes as does the human genome
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Predicting survival outcomes using subsets of significant genes in prognostic marker studies with microarrays.
PMID 16549007 · PMC1544357 · BMC bioinformatics · 2006 · 7 claims · 2 setups
A methodology combining Cox proportional hazards models with a compound covariate, cross-validated log partial likelihood (ACVL) for predictive accuracy, and permutation-based significance testing can identify an optimal subset of significant genes for survival prediction
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Cellular responses to ErbB-2 overexpression in human mammary luminal epithelial cells: comparison of mRNA and protein expression.
PMID 14710226 · PMC2395336 · British journal of cancer · 2004 · 7 claims · 5 setups
There is a surprisingly high correlation between transcription and translation for the subset of genes studied by parallel microarray and proteomics analysis