John G. Doench
Reproducibility track record
1
assessed papers
—
mean reproducibility
0
reproduced (C1–C2)
0
flagged
40
total citations
flag rate:
0%
(0/1)
The share of this author’s assessed papers carrying a ⚑ flag. A concentration is a prompt for expert review — never, on its own, a determination about the person.
Authorship role
first author: 0
last author: 0
Topics
Funders
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Frequent co-authors
Rui Guo 1Roberto Chiarle 1Chang Jiang 1Sizun Jiang 1Bo Zhao 1Zhonghao Wang 1Carole Gautier‐Courteille 1Taek-Chin Cheong 1Mingxiang Teng 1Luc Paillard 1
Institutions
Brigham and Women's Hospital 1Harvard University 1Boston Children's Hospital 1Moffitt Cancer Center 1Sichuan University 1West China Hospital of Sichuan University 1
Geography (author institutions)
US 1CN 1FR 1IT 1
Co-author network
Collaborators, sized by shared output and coloured by their own reproducibility (green = high, red = low). Click a node to open their card. A pattern is a prompt for review, never a determination.
How this author’s assessed papers reproduced — the outcome of reproduction attempts, not a judgement of the person. Coverage is partial and grows over time.
Assessed papers (1)
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CRISPR/Cas9 Screens Reveal Multiple Layers of B cell CD40 Regulation.
2019 L1 No data access
Complete publication record (754)
Request a reproduction →1 assessed by us (0 reproduced) · 753 not yet assessed — every PubMed paper on record, linked below.
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Sialylated CD43 forms a glyco-immune barrier that restrains antileukemic immunity ↗Science · 2026 · PMID 41955354not yet assessed
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Genome-wide CRISPR interference screen identifies Clip2 as a novel regulator of osteocyte maturation and morphology ↗Journal of Biological Chemistry · 2026 · PMID 41279202not yet assessed
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Balancing off-target and on-target considerations for optimized CRISPR-Cas9 knockout library design ↗Cell Genomics · 2026 · PMID 41887225not yet assessed
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Optimized parameters for Cas9 CRISPR interference library design ↗bioRxiv (Cold Spring Harbor Laboratory) · 2026not yet assessed
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Head-to-Head CRISPRko CRISPRi Perturb-seq: Aligned, filtered data with guide assignments ↗Zenodo (CERN European Organization for Nuclear Research) · 2026not yet assessed
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Head-to-Head CRISPRko CRISPRi Perturb-seq: Differential Expression Analysis results ↗Zenodo (CERN European Organization for Nuclear Research) · 2026not yet assessed
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A transcriptional biosensor reveals mechanisms of α-ketoglutarate signaling to chromatin ↗Science · 2026 · PMID 42462028not yet assessed
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Abstract PR010: Deciphering the mechanistic basis of HIFα paralog target selectivity in kidney cancer ↗Cancer Research · 2026not yet assessed
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Abstract 632: Dynamic characterization of tumor-microenvironment factors that drive pediatric low-grade gliomas. ↗Cancer Research · 2026not yet assessed
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A pooled CRISPR screen reveals genes critical for erythroblast enucleation ↗bioRxiv (Cold Spring Harbor Laboratory) · 2026 · PMID 42005862not yet assessed
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KDM6 Enzymes are the Mechanistic Targets of Mutant IDH that Dictate Replication Stress Sensitivity ↗bioRxiv (Cold Spring Harbor Laboratory) · 2026 · PMID 42039522not yet assessed
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CD164 is an endolysomal host factor for entry of Clade A New World Arenaviruses ↗bioRxiv (Cold Spring Harbor Laboratory) · 2026 · PMID 42079147not yet assessed
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Discovery of Tcf7 regulators with clonally-resolved CRISPR screens identifies Trim28 as a mediator of CD8 T cell differentiation in tumors ↗bioRxiv (Cold Spring Harbor Laboratory) · 2026 · PMID 42367935not yet assessed
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Head-to-Head CRISPRko CRISPRi Perturb-seq: Aligned, filtered data with guide assignments ↗Zenodo (CERN European Organization for Nuclear Research) · 2026not yet assessed
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Head-to-Head CRISPRko CRISPRi Perturb-seq: Differential Expression Analysis results ↗Zenodo (CERN European Organization for Nuclear Research) · 2026not yet assessed
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Direct comparison of CRISPR knockout and interference with Perturb-seq ↗bioRxiv (Cold Spring Harbor Laboratory) · 2026not yet assessed
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Head-to-Head CRISPRko CRISPRi Perturb-seq: Aligned, filtered data with guide assignments ↗Zenodo (CERN European Organization for Nuclear Research) · 2026not yet assessed
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Oncogenic Gα signaling requires AP-3-dependent recruitment to the endolysosomal compartment ↗Proceedings of the National Academy of Sciences · 2026 · PMID 42485388not yet assessed
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CRISPR base editor screening identifies spectrum of MEN1 mutations impacting menin inhibitors in clinical trials ↗Nature Communications · 2026 · PMID 42103719not yet assessed
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Processed sequencing data for KRAS deep mutational scanning (variantCounts and aaCounts) ↗Figshare · 2026not yet assessed
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Processed sequencing data for KRAS deep mutational scanning (variantCounts and aaCounts) ↗Figshare · 2026not yet assessed
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Processed sequencing data for KRAS deep mutational scanning (variantCounts and aaCounts) ↗Figshare · 2026not yet assessed
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Abstract B083: GLIO-1 is a selective DHODH inhibitor that is effective in IDH-mutant gliomas and KDM6-mutated cancers ↗Clinical Cancer Research · 2026not yet assessed
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Abstract PR012: GLIO-1 is a selective DHODH inhibitor that is effective in IDH-mutant gliomas and KDM6-mutated cancers ↗Clinical Cancer Research · 2026not yet assessed
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In vivo CRISPR screens identify modifiers of CAR T cell function in myeloma ↗Nature · 2025 · PMID 40993381not yet assessed
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Targeting G1–S-checkpoint-compromised cancers with cyclin A/B RxL inhibitors ↗Nature · 2025 · PMID 40836083not yet assessed
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Morphological map of under- and overexpression of genes in human cells ↗Nature Methods · 2025 · PMID 40775081not yet assessed
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A STUB1–CHIC2 complex inhibits CD8+ T cells to restrain tumor immunity ↗Nature Immunology · 2025 · PMID 40796662not yet assessed
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Activity-based selection for enhanced base editor mutational scanning ↗Nature Genetics · 2025 · PMID 41087678not yet assessed
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Requirement for Cyclin D1 Underlies Cell-Autonomous HIF2 Dependence in Kidney Cancer ↗Cancer Discovery · 2025 · PMID 40178040not yet assessed
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HKU5 bat merbecoviruses engage bat and mink ACE2 as entry receptors ↗Nature Communications · 2025 · PMID 40707428not yet assessed
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Multi-locus CRISPRi targeting with a single truncated guide RNA ↗Nature Communications · 2025 · PMID 39905017not yet assessed
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Defining the Antitumor Mechanism of Action of a Clinical-stage Compound as a Selective Degrader of the Nuclear Pore Complex ↗Cancer Discovery · 2025 · PMID 40891634not yet assessed
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VPS18 contributes to phagosome membrane integrity in <i>Mycobacterium tuberculosis</i> –infected macrophages ↗Science Advances · 2025 · PMID 39888996not yet assessed
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ER protein CLCC1 promotes nuclear envelope fusion in herpesviral and host processes ↗Nature Communications · 2025 · PMID 41271665not yet assessed
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Loss of NOTCH2 creates a TRIM28-dependent vulnerability in small cell lung cancer ↗Developmental Cell · 2025 · PMID 40865518not yet assessed
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HKU5 bat merbecoviruses use divergent mechanisms to engage bat and mink ACE2 as entry receptors ↗bioRxiv (Cold Spring Harbor Laboratory) · 2025not yet assessed
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Balancing off-target and on-target considerations for optimized Cas9 CRISPR knockout library design ↗bioRxiv (Cold Spring Harbor Laboratory) · 2025not yet assessed
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Sialylated CD43 is a glyco-immune checkpoint for macrophage phagocytosis ↗bioRxiv (Cold Spring Harbor Laboratory) · 2025 · PMID 40654991not yet assessed
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Host cyclophilin-mediated maturation of an obligate intracellular bacterial surface virulence factor ↗bioRxiv (Cold Spring Harbor Laboratory) · 2025 · PMID 41280088not yet assessed
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CREB5 promotes immunotherapy resistance via tumor-intrinsic collagen matrix deposition ↗bioRxiv (Cold Spring Harbor Laboratory) · 2025not yet assessed
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Table S4 from Requirement for Cyclin D1 Underlies Cell-Autonomous HIF2 Dependence in Kidney Cancer ↗2025not yet assessed
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Data from Requirement for Cyclin D1 Underlies Cell-Autonomous HIF2 Dependence in Kidney Cancer ↗2025not yet assessed
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Table S8 from Requirement for Cyclin D1 Underlies Cell-Autonomous HIF2 Dependence in Kidney Cancer ↗2025not yet assessed
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Table S3 from Requirement for Cyclin D1 Underlies Cell-Autonomous HIF2 Dependence in Kidney Cancer ↗2025not yet assessed
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Table S7 from Requirement for Cyclin D1 Underlies Cell-Autonomous HIF2 Dependence in Kidney Cancer ↗2025not yet assessed
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Table S6 from Requirement for Cyclin D1 Underlies Cell-Autonomous HIF2 Dependence in Kidney Cancer ↗2025not yet assessed
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Table S5 from Requirement for Cyclin D1 Underlies Cell-Autonomous HIF2 Dependence in Kidney Cancer ↗2025not yet assessed
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Table S2 from Requirement for Cyclin D1 Underlies Cell-Autonomous HIF2 Dependence in Kidney Cancer ↗2025not yet assessed
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Table S1 from Requirement for Cyclin D1 Underlies Cell-Autonomous HIF2 Dependence in Kidney Cancer ↗2025not yet assessed
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Discovery of chromatin-based determinants of azacytidine and decitabine anti-cancer activity ↗bioRxiv (Cold Spring Harbor Laboratory) · 2025 · PMID 40766713not yet assessed
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Identification of Synthetic Lethal Vulnerabilities Between TRIM28 and NOTCH2 in Small Cell Lung Cancer Through CRISPR/Cas9 Screening ↗Journal of Thoracic Oncology · 2025not yet assessed
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Cyclin A/B RxL Macrocyclic Inhibitors to Treat Cancers with High E2F Activity ↗Journal of Thoracic Oncology · 2025not yet assessed
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Sialyl‐T Antigen: A Novel Red Blood Cell Determinant for <i>Plasmodium falciparum</i> Invasion ↗American Journal of Hematology · 2025 · PMID 40884048not yet assessed
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HKU5 bat merbecoviruses engage bat and mink ACE2 as entry receptors ↗UNC Libraries · 2025not yet assessed
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Abstract B023: Identifying effective targeted inhibitors as single-agents or in combination for FGFR1-altered pediatric low-grade gliomas ↗Cancer Research · 2025not yet assessed
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Epigenetic tuning of PD-1 expression improves exhausted T cell function and viral control ↗UNC Libraries · 2025not yet assessed
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Abstract B003: Therapeutic targeting of the nuclear pore complex with molecular glue degraders in pancreatic cancer ↗Cancer Research · 2025not yet assessed
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Three million images and morphological profiles of cells treated with matched chemical and genetic perturbations ↗Nature Methods · 2024 · PMID 38594452not yet assessed
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Efficient gene knockout and genetic interaction screening using the in4mer CRISPR/Cas12a multiplex knockout platform ↗Nature Communications · 2024 · PMID 38678031not yet assessed
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Neuropeptide signalling orchestrates T cell differentiation ↗Nature · 2024 · PMID 39415015not yet assessed
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Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer ↗Cancer Cell · 2024 · PMID 39029464not yet assessed
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Positive selection CRISPR screens reveal a druggable pocket in an oligosaccharyltransferase required for inflammatory signaling to NF-κB ↗Cell · 2024 · PMID 38670073not yet assessed
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Epigenetic tuning of PD-1 expression improves exhausted T cell function and viral control ↗Nature Immunology · 2024 · PMID 39289557not yet assessed
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Targetable leukaemia dependency on noncanonical PI3Kγ signalling ↗Nature · 2024 · PMID 38720074not yet assessed
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Post-translational modification-centric base editor screens to assess phosphorylation site functionality in high throughput ↗Nature Methods · 2024 · PMID 38684783not yet assessed
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Framework for in vivo T cell screens ↗The Journal of Experimental Medicine · 2024 · PMID 38411617not yet assessed
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Germline variation contributes to false negatives in CRISPR-based experiments with varying burden across ancestries ↗Nature Communications · 2024 · PMID 38849329not yet assessed
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Modular vector assembly enables rapid assessment of emerging CRISPR technologies ↗Cell Genomics · 2024 · PMID 38484704not yet assessed
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Host cell CRISPR genomics and modelling reveal shared metabolic vulnerabilities in the intracellular development of Plasmodium falciparum and related hemoparasites ↗Nature Communications · 2024 · PMID 39034325not yet assessed
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Genome-wide CRISPR activation screen identifies JADE3 as an antiviral activator of NF-kB–dependent IFITM3 expression ↗Journal of Biological Chemistry · 2024 · PMID 38462163not yet assessed
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Scanning mutagenesis of the voltage-gated sodium channel NaV1.2 using base editing ↗Cell Reports · 2024 · PMID 38823014not yet assessed
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In Vivo CRISPR Screening Reveals CHD7 as a Positive Regulator of Short-lived Effector Cells ↗The Journal of Immunology · 2024 · PMID 39373572not yet assessed
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Comprehensive structure-function analysis reveals gain- and loss-of-function mechanisms impacting oncogenic KRAS activity ↗bioRxiv (Cold Spring Harbor Laboratory) · 2024 · PMID 39484452not yet assessed
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Cancer target discovery enabled by transcriptome-based virtual CRISPR screening ↗bioRxiv (Cold Spring Harbor Laboratory) · 2024 · PMID 39484513not yet assessed
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Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer ↗bioRxiv (Cold Spring Harbor Laboratory) · 2024 · PMID 38328215not yet assessed
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Cyclin A/B RxL Macrocyclic Inhibitors to Treat Cancers with High E2F Activity ↗bioRxiv (Cold Spring Harbor Laboratory) · 2024 · PMID 39211113not yet assessed
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Morphological map of under- and over-expression of genes in human cells ↗bioRxiv (Cold Spring Harbor Laboratory) · 2024not yet assessed
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In vivo CRISPR screens identify key modifiers of CAR T cell function in myeloma ↗bioRxiv (Cold Spring Harbor Laboratory) · 2024not yet assessed
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CLCC1 promotes membrane fusion during herpesvirus nuclear egress ↗bioRxiv (Cold Spring Harbor Laboratory) · 2024 · PMID 39386602not yet assessed
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Abstract 5858: Systematic identification of pathways associated with antibody drug conjugate sensitivity in breast cancer ↗Cancer Research · 2024not yet assessed
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Abstract 2858: Phenotypic screens identify genetic regulators of nanoparticle delivery to pediatric brain tumors ↗Cancer Research · 2024not yet assessed
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Abstract B015: Combinatorial genetic screens to map synthetic lethal interactions and identify new cancer drug targets in <i>KRAS</i> mutant cancers ↗Molecular Cancer Therapeutics · 2024not yet assessed
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Abstract PR014: Combinatorial genetic screens to map synthetic lethal interactions and identify new cancer drug targets in <i>KRAS</i> mutant cancers ↗Molecular Cancer Therapeutics · 2024not yet assessed
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DIPG-29. PHENOTYPIC SCREENS IDENTIFY GENETIC REGULATORS OF NANOPARTICLE DELIVERY IN DIFFUSE MIDLINE GLIOMAS ↗Neuro-Oncology · 2024not yet assessed
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Methylation Mesa define functional regulatory elements for targeted gene activation ↗Research Square · 2024 · PMID 39483908not yet assessed
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1309 A STUB1-CHIC2 complex decreases IL-27Rα expression on CD8<sup>+</sup> T cells to restrain tumor immunity ↗Regular and Young Investigator Award Abstracts · 2024not yet assessed
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Activity-based selection for enhanced base editor mutational scanning ↗bioRxiv (Cold Spring Harbor Laboratory) · 2024not yet assessed
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A CRISPR Screen in Enucleated Red Blood Cells Identifies Critical Factors for Terminal Erythroid Differentiation ↗Blood · 2024not yet assessed
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SEC62 Regulates HLA-E Expression in Diffuse Large B-Cell Lymphoma to Function As a Mechanism of Immune Evasion ↗Blood · 2024not yet assessed
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MEN1 mutations mediate clinical resistance to menin inhibition ↗Nature · 2023 · PMID 36922589not yet assessed
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ESCRT-dependent STING degradation inhibits steady-state and cGAMP-induced signalling ↗Nature Communications · 2023 · PMID 36739287not yet assessed
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<i>(R)</i> -2-Hydroxyglutarate Inhibits KDM5 Histone Lysine Demethylases to Drive Transformation in <i>IDH</i> -Mutant Cancers ↗Cancer Discovery · 2023 · PMID 36847506not yet assessed
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Pharmacological disruption of mSWI/SNF complex activity restricts SARS-CoV-2 infection ↗Nature Genetics · 2023 · PMID 36894709not yet assessed
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Genome-wide and targeted CRISPR screens identify RNF213 as a mediator of interferon gamma–dependent pathogen restriction in human cells ↗Proceedings of the National Academy of Sciences · 2023 · PMID 38147552not yet assessed
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Developing SHP2-based combination therapy for KRAS-amplified cancer ↗JCI Insight · 2023 · PMID 36752207not yet assessed
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DYRK1A promotes viral entry of highly pathogenic human coronaviruses in a kinase-independent manner ↗PLoS Biology · 2023 · PMID 37310920not yet assessed
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Leukemia-intrinsic determinants of CAR-T response revealed by iterative in vivo genome-wide CRISPR screening ↗Nature Communications · 2023 · PMID 38052854not yet assessed
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Telomerase inhibition is an effective therapeutic strategy in<i>TERT</i>promoter-mutant glioblastoma models with low tumor volume ↗Neuro-Oncology · 2023 · PMID 36694348not yet assessed
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Optimization of Cas12a for multiplexed genome-scale transcriptional activation ↗Cell Genomics · 2023 · PMID 37719144not yet assessed
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Addressing Tumor Heterogeneity by Sensitizing Resistant Cancer Cells to T cell–Secreted Cytokines ↗Cancer Discovery · 2023 · PMID 36811466not yet assessed
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Genome-wide CRISPR screening of chondrocyte maturation newly implicates genes in skeletal growth and height-associated GWAS loci ↗Cell Genomics · 2023 · PMID 37228756not yet assessed
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Transcriptional control of leukemogenesis by the chromatin reader SGF29 ↗Blood · 2023 · PMID 38048593not yet assessed
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Chromatin complex dependencies reveal targeting opportunities in leukemia ↗Nature Communications · 2023 · PMID 36707513not yet assessed
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X-CHIME enables combinatorial, inducible, lineage-specific and sequential knockout of genes in the immune system ↗Nature Immunology · 2023 · PMID 38012416not yet assessed
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LRP6 Is a Functional Receptor for Attenuated Canine Distemper Virus ↗mBio · 2023 · PMID 36645301not yet assessed
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Protocol for in vivo CRISPR screening using selective CRISPR antigen removal lentiviral vectors ↗STAR Protocols · 2023 · PMID 36861834not yet assessed
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Scanning mutagenesis of the voltage-gated sodium channel NaV1.2 using base editing ↗Cell Reports · 2023 · PMID 37267104not yet assessed
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JUMP Cell Painting dataset: morphological impact of 136,000 chemical and genetic perturbations ↗bioRxiv (Cold Spring Harbor Laboratory) · 2023not yet assessed
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Systematically characterizing the roles of E3-ligase family members in inflammatory responses with massively parallel Perturb-seq ↗bioRxiv (Cold Spring Harbor Laboratory) · 2023 · PMID 36747789not yet assessed
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Efficient gene knockout and genetic interactions: the IN4MER CRISPR/Cas12a multiplex knockout platform ↗bioRxiv (Cold Spring Harbor Laboratory) · 2023 · PMID 36712129not yet assessed
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Optimization of Cas12a for multiplexed genome-scale transcriptional activation ↗bioRxiv (Cold Spring Harbor Laboratory) · 2023not yet assessed
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Vps18 contributes to phagosome membrane integrity in <i>Mycobacterium tuberculosis</i> -infected macrophages ↗bioRxiv (Cold Spring Harbor Laboratory) · 2023 · PMID 37873319not yet assessed
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Modular vector assembly enables rapid assessment of emerging CRISPR technologies ↗bioRxiv (Cold Spring Harbor Laboratory) · 2023 · PMID 37961518not yet assessed
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Targetable leukemia dependency on noncanonical PI3Kγ signaling ↗bioRxiv (Cold Spring Harbor Laboratory) · 2023 · PMID 38328043not yet assessed
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Genome-wide CRISPR activation screen identifies JADE3 as an antiviral activator of NF-kB ↗bioRxiv (Cold Spring Harbor Laboratory) · 2023 · PMID 37808733not yet assessed
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Abstract 1696: Systematic identification of pathways associated with antibody drug conjugate sensitivity in breast cancer ↗Cancer Research · 2023not yet assessed
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Proteome-wide base editor screens to assess phosphorylation site functionality in high-throughput ↗bioRxiv (Cold Spring Harbor Laboratory) · 2023 · PMID 38014346not yet assessed
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Combined supplementary figures from The Canonical Wnt Pathway Drives Macropinocytosis in Cancer ↗2023not yet assessed
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Combined supplementary figures from The Canonical Wnt Pathway Drives Macropinocytosis in Cancer ↗2023not yet assessed
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Defining the landscape of cancer vulnerabilities that are engendered by germline genetic variation ↗Journal of Pharmacology and Experimental Therapeutics · 2023not yet assessed
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DIPG-19. BAF COMPLEX PERTURBATION AS A NOVEL THERAPEUTIC OPPORTUNITY IN H3K27M PEDIATRIC GLIOMA ↗Neuro-Oncology · 2023not yet assessed
-
Host metabolic pathways essential for malaria and related hemoparasites in the infection of nucleated cells ↗bioRxiv (Cold Spring Harbor Laboratory) · 2023not yet assessed
-
Multi-locus CRISPRi targeting with a single truncated guide RNA ↗bioRxiv (Cold Spring Harbor Laboratory) · 2023not yet assessed
-
Abstract B021: In vivo gain-of-function screen identifies CREB5, a novel ECM modulator that promotes immunotherapy resistance via the Collagen-Lair1 axis ↗Cancer Immunology Research · 2023not yet assessed
-
not yet assessed
-
Defining a Targetable Leukemia Intrinsic Dependency on Noncanonical PI3Kgamma Signaling ↗Blood · 2023not yet assessed
-
Data from Systematic Functional Interrogation of Rare Cancer Variants Identifies Oncogenic Alleles ↗2023not yet assessed
-
Data from Systematic Functional Interrogation of Rare Cancer Variants Identifies Oncogenic Alleles ↗2023not yet assessed
-
not yet assessed
-
not yet assessed
-
In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer ↗Nature Immunology · 2022 · PMID 36151395not yet assessed
-
Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal HCoVs ↗Nature Genetics · 2022 · PMID 35879413not yet assessed
-
PI3K activation allows immune evasion by promoting an inhibitory myeloid tumor microenvironment ↗Journal for ImmunoTherapy of Cancer · 2022 · PMID 35264433not yet assessed
-
Combinatorial GxGxE CRISPR screen identifies SLC25A39 in mitochondrial glutathione transport linking iron homeostasis to OXPHOS ↗Nature Communications · 2022 · PMID 35513392not yet assessed
-
CRISPR screens for functional interrogation of immunity ↗Nature reviews. Immunology · 2022 · PMID 36481809not yet assessed
-
Phosphate dysregulation via the XPR1–KIDINS220 protein complex is a therapeutic vulnerability in ovarian cancer ↗Nature Cancer · 2022 · PMID 35437317not yet assessed
-
Benchmarking of SpCas9 variants enables deeper base editor screens of BRCA1 and BCL2 ↗Nature Communications · 2022 · PMID 35288574not yet assessed
-
BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma ↗Cancer Discovery · 2022 · PMID 36305736not yet assessed
-
Accounting for small variations in the tracrRNA sequence improves sgRNA activity predictions for CRISPR screening ↗Nature Communications · 2022 · PMID 36068235not yet assessed
-
Base editor scanning charts the DNMT3A activity landscape ↗Nature Chemical Biology · 2022 · PMID 36266353not yet assessed
-
A genome-wide CRISPR screen identifies WDFY3 as a regulator of macrophage efferocytosis ↗Nature Communications · 2022 · PMID 36566259not yet assessed
-
A genetic screen identifies a protective type III interferon response to Cryptosporidium that requires TLR3 dependent recognition ↗PLoS Pathogens · 2022 · PMID 35584177not yet assessed
-
Regulation of neuroendocrine plasticity by the RNA-binding protein ZFP36L1 ↗Nature Communications · 2022 · PMID 36008402not yet assessed
-
A living biobank of canine mammary tumor organoids as a comparative model for human breast cancer ↗Scientific Reports · 2022 · PMID 36302863not yet assessed
-
Reversal of viral and epigenetic HLA class I repression in Merkel cell carcinoma ↗Journal of Clinical Investigation · 2022 · PMID 35775490not yet assessed
-
Systematic Interrogation of Tumor Cell Resistance to Chimeric Antigen Receptor T-cell Therapy in Pancreatic Cancer ↗Cancer Research · 2022 · PMID 36548402not yet assessed
-
Systematic identification of biomarker-driven drug combinations to overcome resistance ↗Nature Chemical Biology · 2022 · PMID 35332332not yet assessed
-
Whole-genome CRISPR screening identifies <i>N-</i>glycosylation as a genetic and therapeutic vulnerability in <i>CALR</i>-mutant MPNs ↗Blood · 2022 · PMID 35763665not yet assessed
-
YAP1 and PRDM14 converge to promote cell survival and tumorigenesis ↗Developmental Cell · 2022 · PMID 34990589not yet assessed
-
In vivo genome-wide CRISPR screening in murine acute myeloid leukemia uncovers microenvironmental dependencies ↗Blood Advances · 2022 · PMID 35793392not yet assessed
-
Selective Polyprotein Processing Determines Norovirus Sensitivity to Trim7 ↗Journal of Virology · 2022 · PMID 35972292not yet assessed
-
A genome-scale CRISPR screen reveals PRMT1 as a critical regulator of androgen receptor signaling in prostate cancer ↗Cell Reports · 2022 · PMID 35196489not yet assessed
-
Three million images and morphological profiles of cells treated with matched chemical and genetic perturbations ↗bioRxiv (Cold Spring Harbor Laboratory) · 2022not yet assessed
-
Base editor scanning charts the DNMT3A activity landscape ↗bioRxiv (Cold Spring Harbor Laboratory) · 2022not yet assessed
-
Molecular Basis for Interferon-mediated Pathogen Restriction in Human Cells ↗bioRxiv (Cold Spring Harbor Laboratory) · 2022not yet assessed
-
Author Correction: DNA methylation enzymes and PRC1 restrict B-cell Epstein–Barr virus oncoprotein expression ↗Nature Microbiology · 2022 · PMID 35505195not yet assessed
-
Germline variation contributes to false negatives in CRISPR-based experiments with varying burden across ancestries ↗bioRxiv (Cold Spring Harbor Laboratory) · 2022not yet assessed
-
Accounting for small variations in the tracrRNA sequence improves sgRNA activity predictions for CRISPR screening ↗bioRxiv (Cold Spring Harbor Laboratory) · 2022not yet assessed
-
A living biobank of canine mammary tumor organoids as a comparative model for human breast cancer ↗bioRxiv (Cold Spring Harbor Laboratory) · 2022not yet assessed
-
Leukemia-intrinsic determinants of CAR-T response revealed by iterative <i>in vivo</i> genome-wide CRISPR screening ↗bioRxiv (Cold Spring Harbor Laboratory) · 2022not yet assessed
-
ESCRT-dependent STING degradation curtails steady-state and cGAMP-induced signaling ↗bioRxiv (Cold Spring Harbor Laboratory) · 2022not yet assessed
-
A Genome-wide CRISPR Screen Identifies WDFY3 as a Novel Regulator of Macrophage Efferocytosis ↗bioRxiv (Cold Spring Harbor Laboratory) · 2022not yet assessed
-
High Density Domain-Focused CRISPR Screens Reveal Novel Epigenetic Regulators of <i>HOX/MEIS</i> Activation in Acute Myeloid Leukemia ↗bioRxiv (Cold Spring Harbor Laboratory) · 2022not yet assessed
-
Novel GPR87/SDC‐1 Complex Modulates Lacritin Rescue of Homeostasis ↗The FASEB Journal · 2022not yet assessed
-
HGG-36. Elucidating the role of long non-coding RNAs in pediatric high grade gliomas ↗Neuro-Oncology · 2022not yet assessed
-
Abstract 5853: <i>(R)</i>-2-hydroxyglutarate inhibits KDM5 histone lysine demethylases to drive tumorigenesis in <i>IDH-mutant</i> cancers ↗Cancer Research · 2022not yet assessed
-
Abstract 6377: Developing combination therapy with SHP2 inhibition for CIN-type gastroesophageal adenocarcinoma with <i>KRAS</i> amplification ↗Cancer Research · 2022not yet assessed
-
Abstract 3610: In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer ↗Cancer Research · 2022not yet assessed
-
Abstract 2402: SMAD4 represses PDAC metastatic colonization through binding FOSL1 enhancer regions ↗Cancer Research · 2022not yet assessed
-
Abstract 1028: Phosphate dysregulation as a novel therapeutic strategy in ovarian and uterine cancers ↗Cancer Research · 2022not yet assessed
-
Abstract SY05-02: Applications of base editor technology in small molecule: Target validation ↗Cancer Research · 2022not yet assessed
-
CRISPR screens reveal neuropeptide signaling orchestrates T helper cell differentiation ↗Research Square · 2022not yet assessed
-
Kinase-independent activity of DYRK1A promotes viral entry of highly pathogenic human coronaviruses ↗bioRxiv (Cold Spring Harbor Laboratory) · 2022not yet assessed
-
Virally mediated mechanisms of HLA class I loss in Merkel cell carcinoma and implications for viral epitope presentation ↗Journal of Investigative Dermatology · 2022not yet assessed
-
Abstract PR004: High-density CRISPR screens reveal mechanisms of chromatin regulation of stemness networks in acute myeloid leukemia ↗Cancer Research · 2022not yet assessed
-
3030 – THE EPIGENETIC REGULATOR LANDSCAPE OF STEMNESS NETWORKS IN ACUTE MYELOID LEUKEMIA ↗Experimental Hematology · 2022not yet assessed
-
Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway ↗Cell · 2021 · PMID 34289345not yet assessed
-
Epigenetic silencing by SETDB1 suppresses tumour intrinsic immunogenicity ↗Nature · 2021 · PMID 33953401not yet assessed
-
Massively parallel assessment of human variants with base editor screens ↗Cell · 2021 · PMID 33606977not yet assessed
-
Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers ↗Nature Genetics · 2021 · PMID 34857952not yet assessed
-
Lrp1 is a host entry factor for Rift Valley fever virus ↗Cell · 2021 · PMID 34559985not yet assessed
-
Tumor-suppressor function of Beclin 1 in breast cancer cells requires E-cadherin ↗Proceedings of the National Academy of Sciences · 2021 · PMID 33495338not yet assessed
-
CARM1 Inhibition Enables Immunotherapy of Resistant Tumors by Dual Action on Tumor Cells and T Cells ↗Cancer Discovery · 2021 · PMID 33707234not yet assessed
-
In vivo screens using a selective CRISPR antigen removal lentiviral vector system reveal immune dependencies in renal cell carcinoma ↗Immunity · 2021 · PMID 33497609not yet assessed
-
Targeting oncoproteins with a positive selection assay for protein degraders ↗Science Advances · 2021 · PMID 33547076not yet assessed
-
SMAD4 represses FOSL1 expression and pancreatic cancer metastatic colonization ↗Cell Reports · 2021 · PMID 34320363not yet assessed
-
Discovery of putative tumor suppressors from CRISPR screens reveals rewired lipid metabolism in acute myeloid leukemia cells ↗Nature Communications · 2021 · PMID 34764293not yet assessed
-
Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal coronaviruses ↗bioRxiv (Cold Spring Harbor Laboratory) · 2021 · PMID 34031654not yet assessed
-
Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal HCoVs ↗Research Square · 2021 · PMID 34075371not yet assessed
-
Author Correction: Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis ↗Nature Chemical Biology · 2021 · PMID 33654315not yet assessed
-
Benchmarking of SpCas9 variants enables deeper base editor screens of <i>BRCA1</i> and <i>BCL2</i> ↗bioRxiv (Cold Spring Harbor Laboratory) · 2021not yet assessed
-
Regulation of Neuroendocrine Plasticity by the RNA-Binding Protein ZFP36L1 ↗bioRxiv (Cold Spring Harbor Laboratory) · 2021not yet assessed
-
Combinatorial <i>G</i> x <i>G</i> x <i>E</i> CRISPR screening and functional analysis highlights SLC25A39 in mitochondrial GSH transport ↗bioRxiv (Cold Spring Harbor Laboratory) · 2021not yet assessed
-
Combinatorial G x G x E CRISPR screening and functional analysis highlights SLC25A39 in mitochondrial GSH transport ↗Research Square · 2021not yet assessed
-
A genetic screen identifies a protective type III interferon response to <i>Cryptosporidium</i> that requires TLR3 dependent recognition ↗bioRxiv (Cold Spring Harbor Laboratory) · 2021not yet assessed
-
not yet assessed
-
Abstract PO009: Epigenetic silencing by SETDB1 represses tumor-cell intrinsic immunogenicity ↗Cancer Immunology Research · 2021not yet assessed
-
Title: (R)-2-Hydroxyglutarate Inhibits KDM5 Histone Lysine Demethylases to Drive Tumorigenesis in IDH-Mutant Cancers ↗SSRN Electronic Journal · 2021not yet assessed
-
TRIMming viral infection: identification and characterization of the novel antiviral TRIM7 ↗The Journal of Immunology · 2021not yet assessed
-
Discovering the anticancer potential of non-oncology drugs by systematic viability profiling ↗Nature Cancer · 2020 · PMID 32613204not yet assessed
-
Cytochrome P450 oxidoreductase contributes tophospholipid peroxidation in ferroptosis ↗Nature Chemical Biology · 2020 · PMID 32080622not yet assessed
-
Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection ↗Cell · 2020 · PMID 33147444not yet assessed
-
Intercellular Mitochondria Transfer to Macrophages Regulates White Adipose Tissue Homeostasis and Is Impaired in Obesity ↗Cell Metabolism · 2020 · PMID 33278339not yet assessed
-
Cas9 activates the p53 pathway and selects for p53-inactivating mutations ↗Nature Genetics · 2020 · PMID 32424350not yet assessed
-
Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection ↗Nature Communications · 2020 · PMID 31919360not yet assessed
-
Optimization of AsCas12a for combinatorial genetic screens in human cells ↗Nature Biotechnology · 2020 · PMID 32661438not yet assessed
-
Design and analysis of CRISPR–Cas experiments ↗Nature Biotechnology · 2020 · PMID 32284587not yet assessed
-
Genetic screens in isogenic mammalian cell lines without single cell cloning ↗Nature Communications · 2020 · PMID 32029722not yet assessed
-
Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death ↗Nature Communications · 2020 · PMID 32483148not yet assessed
-
MYC Controls the Epstein-Barr Virus Lytic Switch ↗Molecular Cell · 2020 · PMID 32315601not yet assessed
-
Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers ↗Blood · 2020 · PMID 32458004not yet assessed
-
Genome-wide In Vivo CNS Screening Identifies Genes that Modify CNS Neuronal Survival and mHTT Toxicity ↗Neuron · 2020 · PMID 32004439not yet assessed
-
DNA methylation enzymes and PRC1 restrict B-cell Epstein–Barr virus oncoprotein expression ↗Nature Microbiology · 2020 · PMID 32424339not yet assessed
-
UFMylation inhibits the proinflammatory capacity of interferon-γ–activated macrophages ↗Proceedings of the National Academy of Sciences · 2020 · PMID 33372156not yet assessed
-
Progression signature underlies clonal evolution and dissemination of multiple myeloma ↗Blood · 2020 · PMID 33150374not yet assessed
-
Illuminating Host-Mycobacterial Interactions with Genome-wide CRISPR Knockout and CRISPRi Screens ↗Cell Systems · 2020 · PMID 32970993not yet assessed
-
Mechanistic insights into cancer cell killing through interaction of phosphodiesterase 3A and schlafen family member 12 ↗Journal of Biological Chemistry · 2020 · PMID 32005668not yet assessed
-
CRISPR-Cas9 Genome-Wide Knockout Screen Identifies Mechanism of Selective Activity of Dehydrofalcarinol in Mesenchymal Stem-like Triple-Negative Breast Cancer Cells ↗Journal of Natural Products · 2020 · PMID 33021790not yet assessed
-
not yet assessed
-
Genome-Wide CRISPR/Cas9 Screen Towards Identification of the Lacritin Homeostasis ReceptorInvestigative Ophthalmology & Visual Science · 2020not yet assessed
-
Genome-wide CRISPR screen reveals host genes that regulate SARS-CoV-2 infection ↗bioRxiv (Cold Spring Harbor Laboratory) · 2020 · PMID 32869025not yet assessed
-
Massively parallel assessment of human variants with base editor screens ↗bioRxiv (Cold Spring Harbor Laboratory) · 2020not yet assessed
-
Author Correction: Cas9 activates the p53 pathway and selects for p53-inactivating mutations ↗Nature Genetics · 2020 · PMID 32587373not yet assessed
-
Phosphate dysregulation via the XPR1:KIDINS220 protein complex is a therapeutic vulnerability in ovarian cancer ↗bioRxiv (Cold Spring Harbor Laboratory) · 2020not yet assessed
-
not yet assessed
-
Functional Genetic Screens to Dissect the Essentialome of Disease ↗Journal of Comparative Pathology · 2020not yet assessed
-
Abstract B47: CHIME screening identifies PTPN2 as a novel regulator of antitumor immunity ↗Cancer Immunology Research · 2020not yet assessed
-
Illuminating host-mycobacterial interactions with functional genomic screening to inhibit mycobacterial pathogenesis ↗bioRxiv (Cold Spring Harbor Laboratory) · 2020not yet assessed
-
Genome-scale genetic screening identifies PRMT1 as a critical vulnerability in castration-resistant prostate cancer ↗European Journal of Cancer · 2020not yet assessed
-
High-Throughput CRISPR Screens to Dissect Macrophage- <i>Shigella</i> Interactions ↗SSRN Electronic Journal · 2020not yet assessed
-
Correction: Mechanistic insights into cancer cell killing through interaction of phosphodiesterase 3A and schlafen family member 12. ↗Journal of Biological Chemistry · 2020not yet assessed
-
High-throughput CRISPR screens to dissect macrophage- <i>Shigella</i> interactions ↗bioRxiv (Cold Spring Harbor Laboratory) · 2020not yet assessed
-
Identifying regulators of reversible MHC I loss in Merkel cell carcinoma through genome-scale screens ↗The Journal of Immunology · 2020not yet assessed
-
A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis ↗Nature Communications · 2019 · PMID 30962421not yet assessed
-
Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy ↗Nature · 2019 · PMID 31827283not yet assessed
-
Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies ↗Cancer Cell · 2019 · PMID 31543463not yet assessed
-
Agreement between two large pan-cancer CRISPR-Cas9 gene dependency data sets ↗Nature Communications · 2019 · PMID 31862961not yet assessed
-
Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion ↗Cell Metabolism · 2019 · PMID 30799286not yet assessed
-
A Compendium of Genetic Modifiers of Mitochondrial Dysfunction Reveals Intra-organelle Buffering ↗Cell · 2019 · PMID 31730859not yet assessed
-
A CRISPR-Cas9 delivery system for in vivo screening of genes in the immune system ↗Nature Communications · 2019 · PMID 30971695not yet assessed
-
CRISPR-suppressor scanning reveals a nonenzymatic role of LSD1 in AML ↗Nature Chemical Biology · 2019 · PMID 30992567not yet assessed
-
Natural variation in C. elegans arsenic toxicity is explained by differences in branched chain amino acid metabolism ↗eLife · 2019 · PMID 30958264not yet assessed
-
Autophagy genes in myeloid cells counteract IFNγ-induced TNF-mediated cell death and fatal TNF-induced shock ↗Proceedings of the National Academy of Sciences · 2019 · PMID 31346084not yet assessed
-
CRISPR-Switch regulates sgRNA activity by Cre recombination for sequential editing of two loci ↗Nature Communications · 2019 · PMID 31784531not yet assessed
-
CRISPR/Cas9 Screens Reveal Multiple Layers of B cell CD40 RegulationCell Reports · 2019 · PMID 31365872L1 No data access
-
6-Phosphogluconate Dehydrogenase Links Cytosolic Carbohydrate Metabolism to Protein Secretion via Modulation of Glutathione Levels ↗Cell chemical biology · 2019 · PMID 31204288not yet assessed
-
Discovering metabolic disease gene interactions by correlated effects on cellular morphology ↗Molecular Metabolism · 2019 · PMID 30940487not yet assessed
-
Gene-centric functional dissection of human genetic variation uncovers regulators of hematopoiesis ↗eLife · 2019 · PMID 31070582not yet assessed
-
Non-oncology drugs are a source of previously unappreciated anti-cancer activity ↗bioRxiv (Cold Spring Harbor Laboratory) · 2019not yet assessed
-
Agreement between two large pan-cancer CRISPR-Cas9 gene dependency datasets ↗bioRxiv (Cold Spring Harbor Laboratory) · 2019not yet assessed
-
Genetic screens in isogenic mammalian cell lines without single cell cloning ↗bioRxiv (Cold Spring Harbor Laboratory) · 2019not yet assessed
-
Optimization of AsCas12a for combinatorial genetic screens in human cells ↗bioRxiv (Cold Spring Harbor Laboratory) · 2019not yet assessed
-
not yet assessed
-
not yet assessed
-
Abstract GMM-027: DYNLL1 INHIBITS DNA END RESECTION IN BRCA1-DEFICIENT CELLS AND REGULATES PARP INHIBITOR SENSITIVITY ↗Clinical Cancer Research · 2019not yet assessed
-
Abstract A146: Systematic discovery of immune regulatory mechanisms in tumor cells ↗Cancer Immunology Research · 2019not yet assessed
-
Abstract 2690: Massively parallel multiplexed methods to screen hundreds of barcoded cancer cell line models with small molecules or genetic perturbations using next-generation sequencing ↗Experimental and Molecular Therapeutics · 2019not yet assessed
-
Abstract 2948: Novel cell line barcoding method reveals tepoxalin as a selective drug against MDR1-high tumor cells ↗Experimental and Molecular Therapeutics · 2019not yet assessed
-
Gain-of-function studies with CRISPR-based transcriptional activation at endogenous genomic loci reveals genes with critical roles for myeloma cells ↗Clinical Lymphoma Myeloma & Leukemia · 2019not yet assessed
-
Combinatorial CRISPR-knockout identifies interactions between key genes and regulatory pathways in myeloma ↗Clinical Lymphoma Myeloma & Leukemia · 2019not yet assessed
-
not yet assessed
-
not yet assessed
-
not yet assessed
-
CRISPR/Cas9 Screens Reveal Multiple Layers of B Cell CD40 Regulation ↗SSRN Electronic Journal · 2019not yet assessed
-
Reprogrammation mitochondriale à l’origine de la résistance au vénétoclax dans les hémopathies lymphoïdesHAL (Le Centre pour la Communication Scientifique Directe) · 2019not yet assessed
-
Progression signature underlies clonal evolution and dissemination of Multiple Myeloma ↗Clinical Lymphoma Myeloma & Leukemia · 2019not yet assessed
-
Abstract 2690: Massively parallel multiplexed methods to screen hundreds of barcoded cancer cell line models with small molecules or genetic perturbations using next-generation sequencing ↗Cancer Research · 2019not yet assessed
-
Abstract 2948: Novel cell line barcoding method reveals tepoxalin as a selective drug against MDR1-high tumor cells ↗Cancer Research · 2019not yet assessed
-
Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities ↗Nature Communications · 2018 · PMID 30575746not yet assessed
-
A major chromatin regulator determines resistance of tumor cells to T cell–mediated killing ↗Science · 2018 · PMID 29301958not yet assessed
-
Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade ↗Nature · 2018 · PMID 30559380not yet assessed
-
Mutational processes shape the landscape of TP53 mutations in human cancer ↗Nature Genetics · 2018 · PMID 30224644not yet assessed
-
Prediction of off-target activities for the end-to-end design of CRISPR guide RNAs ↗Nature Biomedical Engineering · 2018 · PMID 29998038not yet assessed
-
PPM1D-truncating mutations confer resistance to chemotherapy and sensitivity to PPM1D inhibition in hematopoietic cells ↗Blood · 2018 · PMID 29954749not yet assessed
-
DYNLL1 binds to MRE11 to limit DNA end resection in BRCA1-deficient cells ↗Nature · 2018 · PMID 30464262not yet assessed
-
An alternative splicing switch in FLNB promotes the mesenchymal cell state in human breast cancer ↗eLife · 2018 · PMID 30059005not yet assessed
-
The Canonical Wnt Pathway Drives Macropinocytosis in Cancer ↗Cancer Research · 2018 · PMID 29871936not yet assessed
-
Uncoupling of sgRNAs from their associated barcodes during PCR amplification of combinatorial CRISPR screens ↗PLoS ONE · 2018 · PMID 29799876not yet assessed
-
CRISPR Screen Reveals that EHEC’s T3SS and Shiga Toxin Rely on Shared Host Factors for Infection ↗mBio · 2018 · PMID 29921669not yet assessed
-
Identification of Antinorovirus Genes in Human Cells Using Genome-Wide CRISPR Activation Screening ↗Journal of Virology · 2018 · PMID 30305350not yet assessed
-
Nitric Oxide Engages an Anti-inflammatory Feedback Loop Mediated by Peroxiredoxin 5 in Phagocytes ↗Cell Reports · 2018 · PMID 30044981not yet assessed
-
A FACS-Based Genome-wide CRISPR Screen Reveals a Requirement for COPI in Chlamydia trachomatis Invasion ↗iScience · 2018 · PMID 30590252not yet assessed
-
miR-196b target screen reveals mechanisms maintaining leukemia stemness with therapeutic potential ↗The Journal of Experimental Medicine · 2018 · PMID 29997117not yet assessed
-
A case of mistaken identity ↗Nature Biotechnology · 2018 · PMID 30188534not yet assessed
-
Optimization and Initiation of a Genome‐Wide Forward Genetic Death Screen for the Lacritin Receptor Complex using the Brunello CRISPR/Cas 9 sgRNA Library ↗The FASEB Journal · 2018not yet assessed
-
HIF-2α drives an intrinsic vulnerability to ferroptosis in clear cell renal cell carcinoma ↗bioRxiv (Cold Spring Harbor Laboratory) · 2018not yet assessed
-
Uncoupling of sgRNAs from their associated barcodes during PCR amplification of combinatorial CRISPR screens ↗bioRxiv (Cold Spring Harbor Laboratory) · 2018not yet assessed
-
Up, down, and out: optimized libraries for CRISPRa, CRISPRi, and CRISPR-knockout genetic screens ↗bioRxiv (Cold Spring Harbor Laboratory) · 2018not yet assessed
-
Identification of anti-norovirus genes in mouse and human cells using genome-wide CRISPR activation screening ↗bioRxiv (Cold Spring Harbor Laboratory) · 2018not yet assessed
-
not yet assessed
-
CRISPR screen reveals that EHEC’s T3SS and Shiga toxin rely on shared host factors for infection ↗bioRxiv (Cold Spring Harbor Laboratory) · 2018not yet assessed
-
not yet assessed
-
Gene-centric functional dissection of human genetic variation uncovers regulators of hematopoiesis ↗bioRxiv (Cold Spring Harbor Laboratory) · 2018not yet assessed
-
not yet assessed
-
not yet assessed
-
Abstract 706: In vivo tumor-associated mutation screen identifies PI3K activation as a mechanism of resistance to PD-1 blockade ↗Cancer Research · 2018not yet assessed
-
In Vivo Profiling of Leukemic Stem Cell Fitness Identifies Therapeutically Actionable Determinants of Growth ↗Experimental Hematology · 2018not yet assessed
-
not yet assessed
-
not yet assessed
-
Natural variation in <i>C. elegans</i> arsenic toxicity is explained by differences in branched chain amino acid metabolism ↗bioRxiv (Cold Spring Harbor Laboratory) · 2018not yet assessed
-
A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles ↗Cell · 2017 · PMID 29195078not yet assessed
-
Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway ↗Nature · 2017 · PMID 28678785not yet assessed
-
In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target ↗Nature · 2017 · PMID 28723893not yet assessed
-
Am I ready for CRISPR? A user's guide to genetic screens ↗Nature Reviews Genetics · 2017 · PMID 29199283not yet assessed
-
Orthologous CRISPR–Cas9 enzymes for combinatorial genetic screens ↗Nature Biotechnology · 2017 · PMID 29251726not yet assessed
-
Evaluation of RNAi and CRISPR technologies by large-scale gene expression profiling in the Connectivity Map ↗PLoS Biology · 2017 · PMID 29190685not yet assessed
-
KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer ↗eLife · 2017 · PMID 28145866not yet assessed
-
CRISPR/Cas9 Screens Reveal Epstein-Barr Virus-Transformed B Cell Host Dependency Factors ↗Cell Host & Microbe · 2017 · PMID 28494239not yet assessed
-
ATXN1L, CIC, and ETS Transcription Factors Modulate Sensitivity to MAPK Pathway Inhibition ↗Cell Reports · 2017 · PMID 28178529not yet assessed
-
Functional screen of MSI2 interactors identifies an essential role for SYNCRIP in myeloid leukemia stem cells ↗Nature Genetics · 2017 · PMID 28436985not yet assessed
-
Natural variation in a single amino acid substitution underlies physiological responses to topoisomerase II poisons ↗PLoS Genetics · 2017 · PMID 28700616not yet assessed
-
Creation of Novel Protein Variants with CRISPR/Cas9-Mediated Mutagenesis: Turning a Screening By-Product into a Discovery Tool ↗PLoS ONE · 2017 · PMID 28118392not yet assessed
-
Decomposing Oncogenic Transcriptional Signatures to Generate Maps of Divergent Cellular States ↗Cell Systems · 2017 · PMID 28837809not yet assessed
-
PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA ↗Nature Communications · 2017 · PMID 28447610not yet assessed
-
High-throughput Phenotyping of Lung Cancer Somatic Mutations ↗Cancer Cell · 2017not yet assessed
-
Synergistic interactions with PI3K inhibition that induce apoptosis ↗eLife · 2017 · PMID 28561737not yet assessed
-
not yet assessed
-
A Next Generation Connectivity Map: L1000 Platform And The First 1,000,000 Profiles ↗bioRxiv (Cold Spring Harbor Laboratory) · 2017not yet assessed
-
Evaluation of RNAi and CRISPR technologies by large-scale gene expression profiling in the Connectivity Map ↗bioRxiv (Cold Spring Harbor Laboratory) · 2017not yet assessed
-
Correction: KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer ↗eLife · 2017 · PMID 29087937not yet assessed
-
Natural variation in a single amino acid underlies cellular responses to topoisomerase II poisons ↗bioRxiv (Cold Spring Harbor Laboratory) · 2017not yet assessed
-
Correction: Corrigendum: PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA ↗Nature Communications · 2017 · PMID 28607496not yet assessed
-
Abstract 3182: Cytoskeletal modulation results in increased tumor survival and drug resistance through attenuation of p53 dependent apoptosis ↗Cancer Research · 2017not yet assessed
-
Abstract 1019: <i>In vivo</i> CRISPR screening identifies Ptpn2 as a target for cancer immunotherapy ↗Cancer Research · 2017not yet assessed
-
not yet assessed
-
Abstract 417: Defining molecular mechanisms of resistance to glioblastoma immunity using a novel CRISPR/Cas9 <i>in vivo</i> loss-of-function screening platform ↗Cancer Research · 2017not yet assessed
-
Abstract 5020: A genome-scale ORF screen reveals an alternative splicing program that regulates mesenchymal and stem-like cell states in breast cancer ↗Cancer Research · 2017not yet assessed
-
A genome-wide, in vivo dropout CRISPR screen in acute myeloid leukemia ↗Experimental Hematology · 2017not yet assessed
-
Abstract A36: Genome-scale ORF screening to identify modulators of the epithelial-to-mesenchymal transition ↗Molecular Cancer Therapeutics · 2017not yet assessed
-
IMMU-28. DEFINING MOLECULAR MECHANISMS OF RESISTANCE TO GLIOBLASTOMA (GBM) IMMUNITY USING A NOVEL CRISPR/CAS9 IN VIVO LOSS-OF-FUNCTION SCREENING PLATFORM ↗Neuro-Oncology · 2017not yet assessed
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Abstract IA13: RNA regulators and the control of self-renewal ↗Clinical Cancer Research · 2017not yet assessed
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not yet assessed
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Defining Molecular Mechanisms of Resistance to Glioblastoma (GBM) Immunity (P1.163) ↗Neurology · 2017not yet assessed
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Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9 ↗Nature Biotechnology · 2016 · PMID 26780180not yet assessed
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A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation ↗Cell Metabolism · 2016 · PMID 27667664not yet assessed
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Discovery of a proteinaceous cellular receptor for a norovirus ↗Science · 2016 · PMID 27540007not yet assessed
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High-throughput Phenotyping of Lung Cancer Somatic Mutations ↗Cancer Cell · 2016 · PMID 27478040not yet assessed
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Systematic Functional Interrogation of Rare Cancer Variants Identifies Oncogenic Alleles ↗Cancer Discovery · 2016 · PMID 27147599not yet assessed
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Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers ↗Cell Systems · 2016 · PMID 27684187not yet assessed
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CRISPR/Cas9 Screens Reveal Requirements for Host Cell Sulfation and Fucosylation in Bacterial Type III Secretion System-Mediated Cytotoxicity ↗Cell Host & Microbe · 2016 · PMID 27453484not yet assessed
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Bromodomain Inhibitors Correct Bioenergetic Deficiency Caused by Mitochondrial Disease Complex I Mutations ↗Molecular Cell · 2016 · PMID 27666594not yet assessed
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<scp>CRISPR</scp>/Cas9 gene editing special issue ↗FEBS Journal · 2016 · PMID 27596525not yet assessed
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not yet assessed
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not yet assessed
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Genome-Scale Screen Reveals Genes Required for Lenalidomide-Mediated Degradation of Aiolos By CRL4-CRBN ↗Blood · 2016not yet assessed
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Predicting off-target effects for end-to-end CRISPR guide design ↗bioRxiv (Cold Spring Harbor Laboratory) · 2016not yet assessed
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Abstract 4368: High-throughput phenotyping of lung cancer somatic mutations ↗Cancer Research · 2016not yet assessed
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Mapping protein function with CRISPR/Cas9-mediated mutagenesis ↗bioRxiv (Cold Spring Harbor Laboratory) · 2016not yet assessed
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DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia ↗Nature Medicine · 2015 · PMID 25822366not yet assessed
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Integrative Analyses of Human Reprogramming Reveal Dynamic Nature of Induced Pluripotency ↗Cell · 2015 · PMID 26186193not yet assessed
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Alternative to the soft-agar assay that permits high-throughput drug and genetic screens for cellular transformation ↗Proceedings of the National Academy of Sciences · 2015 · PMID 25902495not yet assessed
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A forward genetic screen identifies erythrocyte CD55 as essential for <i>Plasmodium falciparum</i> invasion ↗Science · 2015 · PMID 25954012not yet assessed
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Genetic screens and functional genomics using <scp>CRISPR</scp>/Cas9 technology ↗FEBS Journal · 2015 · PMID 25728500not yet assessed
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Morphological Profiles of RNAi-Induced Gene Knockdown Are Highly Reproducible but Dominated by Seed Effects ↗PLoS ONE · 2015 · PMID 26197079not yet assessed
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Functional genomics identifies negative regulatory nodes controlling phagocyte oxidative burst ↗Nature Communications · 2015 · PMID 26194095not yet assessed
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<i>In Silico</i> Predictive Modeling of CRISPR/Cas9 guide efficiency ↗bioRxiv (Cold Spring Harbor Laboratory) · 2015not yet assessed
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not yet assessed
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Abstract PR07: Towards precision functional genomics via next-generation functional mapping of cancer variants ↗Cancer Research · 2015not yet assessed
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Integrative Analyses of Human Reprogramming Reveal Dynamic Nature of Induced PluripotencyDSpace@MIT (Massachusetts Institute of Technology) · 2015not yet assessed
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Abstract 957: Towards precision functional genomics via next-generation functional mapping of cancer variants ↗Cancer Research · 2015not yet assessed
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Rational design of highly active sgRNAs for CRISPR-Cas9–mediated gene inactivation ↗Nature Biotechnology · 2014 · PMID 25184501not yet assessed
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HDAC5 Controls MEF2C-Driven Sclerostin Expression in Osteocytes ↗Journal of Bone and Mineral Research · 2014 · PMID 25271055not yet assessed
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Targeted shRNA screening identified critical roles of pleckstrin-2 in erythropoiesis ↗Haematologica · 2014 · PMID 24747950not yet assessed
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Discovery and Characterization of Super-Enhancer-Associated Dependencies in Diffuse Large B Cell Lymphoma ↗Cancer Cell · 2014not yet assessed
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Abstract 3316: Characterizing mechanisms of resistance to androgen deprivation in prostate cancer ↗Cancer Research · 2014not yet assessed
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Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells ↗Science · 2013 · PMID 24336571not yet assessed
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Discovery and Characterization of Super-Enhancer-Associated Dependencies in Diffuse Large B Cell Lymphoma ↗Cancer Cell · 2013 · PMID 24332044not yet assessed
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SYK Inhibition Modulates Distinct PI3K/AKT- Dependent Survival Pathways and Cholesterol Biosynthesis in Diffuse Large B Cell Lymphomas ↗Cancer Cell · 2013 · PMID 23764004not yet assessed
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Abstract B230: Targeting mitochondria for metastatic lung adenocarcinoma specific lethality. ↗Molecular Cancer Therapeutics · 2013not yet assessed
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Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach ↗Nature Immunology · 2012 · PMID 23263557not yet assessed
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Reduced Expression of Ribosomal Proteins Relieves MicroRNA-Mediated Repression ↗Molecular Cell · 2012 · PMID 22541556not yet assessed
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Abstract 2957: Uncovering tumor-specific components of the p53 pathway using mouse models and RNAi ↗Cancer Research · 2012not yet assessed
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not yet assessed
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not yet assessed
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Kinase requirements in human cells: I. Comparing kinase requirements across various cell types ↗Proceedings of the National Academy of Sciences · 2008 · PMID 18948591not yet assessed
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Comparison of siRNA-induced off-target RNA and protein effects ↗RNA · 2007 · PMID 17237357not yet assessed
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Analysis of microRNA effector functions in vitro ↗Methods · 2007 · PMID 17889795not yet assessed
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Recapitulation of Short RNA-Directed Translational Gene Silencing In Vitro ↗Molecular Cell · 2006 · PMID 16713585not yet assessed
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The biology of short RNAs2006not yet assessed
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19 The Biology of Short RNAs ↗Cold Spring Harbor Monograph Archive · 2006not yet assessed
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RNA Interference ↗Encyclopedia of Molecular Cell Biology and Molecular Medicine · 2006not yet assessed
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RNA interference of Xenopus NMDAR NR1 in vitro and in vivo ↗Journal of Neuroscience Methods · 2005 · PMID 16182372not yet assessed
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Screens Using RNAi and cDNA Expression as Surrogates for Genetics in Mammalian Tissue Culture Cells ↗Cold Spring Harbor Symposia on Quantitative Biology · 2005 · PMID 16869783not yet assessed
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Specificity and mechanism of microRNAs in the regulation of gene expressionDSpace@MIT (Massachusetts Institute of Technology) · 2005not yet assessed
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Specificity of microRNA target selection in translational repression ↗Genes & Development · 2004 · PMID 15014042not yet assessed
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siRNAs can function as miRNAs ↗Genes & Development · 2003 · PMID 12600936not yet assessed
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Distribution of physiological adult lactase phenotypes, lactose absorber and malabsorber, in Germany ↗Human Genetics · 1982 · PMID 6819221not yet assessed
Full bibliography from OpenAlex; reproducibility verdicts matched by PMID.
Author attribution follows OpenAlex disambiguation, which is imperfect — a researcher's papers can be split across profiles or mixed with a namesake.
Merged across profiles sharing this ORCID where present. See every “Doench J” paper on PubMed ↗